Periodontal disease as a possible cause for Alzheimer's disease

2020 ◽  
Vol 83 (1) ◽  
pp. 242-271 ◽  
Author(s):  
Angela R. Kamer ◽  
Ronald G. Craig ◽  
Richard Niederman ◽  
Juan Fortea ◽  
Mony J. de Leon
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Periodontal Disease ◽  
Possible Cause

scholarly journals Emerging evidence for associations between periodontitis and the development of Alzheimer’s disease

2014 ◽  
Vol 5 (1) ◽  
pp. 38-42 ◽  
Author(s):  
Sophie Poole ◽  
Sim K Singhrao ◽  
St John Crean
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Immune Responses ◽  
Periodontal Disease ◽  
Potential Risk ◽  
Inflammatory Disease ◽  
Pathogenic Bacteria ◽  
Late Onset ◽  
Systemic Circulation

Periodontal disease (PD) is an inflammatory disease affecting tooth-supporting tissues in which interaction of specific bacteria and the host’s immune responses play a pivotal role. The pathogenic bacteria associated with PD are a source of systemic inflammation as they have the ability to enter systemic circulation during everyday tasks such as brushing teeth and chewing food. Alzheimer’s disease (AD) is a form of dementia whereby inflammation is thought to play a key role in its pathogenesis and the risk of developing the disease increasing with age. The exact aetiology of the late-onset AD is unknown but peripheral infections are being considered as a potential risk factor.

Dementia With Lewy Bodies in a Nigerian: A Case Report

2002 ◽  
Vol 14 (2) ◽  
pp. 211-218 ◽  
Author(s):  
Adesola Ogunniyi ◽  
Effiong E. U. Akang ◽  
Oye Gureje ◽  
Masaki Takao ◽  
Pedro Piccardo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Case Report ◽  
Dementia With Lewy Bodies ◽  
Clinical Presentation ◽  
Lewy Bodies ◽  
Sub Saharan Africa ◽  
Nigerian Subjects ◽  
Sub Saharan ◽  
Possible Cause

Dementia with Lewy bodies (DLB) is the second most common neuropathologically diagnosed cause of degenerating dementia after Alzheimer's disease. We report the first autopsy-confirmed case in sub-Saharan Africa in a Nigerian patient. The case presented highlights the varied clinical presentation of DLB, and is intended to raise awareness about another possible cause of dementia in Nigerian subjects.

scholarly journals Analysis the Link between Periodontal Diseases and Alzheimer’s Disease: A Systematic Review

2021 ◽  
Vol 18 (17) ◽  
pp. 9312
Author(s):  
Leslie Borsa ◽  
Margaux Dubois ◽  
Guillaume Sacco ◽  
Laurence Lupi
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Periodontal Disease ◽  
Periodontal Diseases ◽  
Fold Increase ◽  
Assessment Tools ◽  
Cochrane Library ◽  
The Cochrane Library

The hypothesis of an infectious connection from the oro-pharyngeal sphere to the brain underlines the interest in analyzing the link between periodontal disease and Alzheimer’s disease. The aim of this systematic review was to examine the link between Alzheimer’s disease and periodontal disease in patients aged 65 and over. Databases (PubMed (MEDLINE), the Cochrane Library, and Embase) were analyzed for relevant references up to 21 June 2021. The authors independently selected the studies and extracted the data. The quality of included studies was checked using the National Institutes of Health’s quality assessment tools. Five studies were included. The selected studies described in their results an increase in F. nucleatum in Alzheimer’s disease patients (adjusted p = 0.02), and its incidence was linked to C. rectus and P. gingivalis (adjusted HR = 1.22 (1.04–1.43), p = 0.012) as well as A. naeslundii (crude HR = 2.0 (1.1–3.8)). The presence of periodontitis at baseline was associated with a six-fold increase in the rate of cognitive decline over a 6-month follow-up period (ADAS-Cog mean change = 2.9 ± 6.6). The current review suggests an association between periodontal disease and Alzheimer’s disease. The treatment of periodontal disease could be a way to explore Alzheimer’s disease prevention.

scholarly journals Periodontal disease exacerbates Alzheimer's disease

2018 ◽  
Vol 60 (3) ◽  
pp. 147-152
Author(s):  
Naoyuki Ishida ◽  
Nobuo Yoshinari ◽  
Kenji Matsushita ◽  
Yuichi Ishihara
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Periodontal Disease

scholarly journals Can Better Management of Periodontal Disease Delay the Onset and Progression of Alzheimer’s Disease?

2017 ◽  
Vol 58 (2) ◽  
pp. 337-348 ◽  
Author(s):  
Alice Harding ◽  
Sarita Robinson ◽  
StJohn Crean ◽  
Sim K. Singhrao
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Periodontal Disease

scholarly journals Periodontal Disease as a Possible Risk Factor for Alzheimer’s Disease

2015 ◽  
pp. 237-243
Author(s):  
Naoyuki Ishida ◽  
Yuichi Ishihara ◽  
Kazuto Ishida ◽  
Hiroyuki Tada ◽  
Yoshiko Kato ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Periodontal Disease

Does periodontal disease elevate the risk of Alzheimer's disease and mild cognitive impairment?

2021 ◽  
Vol 22 (4) ◽  
pp. 123-125
Author(s):  
Kunaal Dhingra ◽  
Wolf-Dieter Grimm ◽  
Prabhat Kumar Chaudhari ◽  
Flora Verma
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Periodontal Disease
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