High‐throughput screening of secondary metabolites by Sorbus pohuashanensis cells under environmental stress using UHPLC‐QTOF combined with AntDAS

2021 ◽  
Author(s):  
Jian Yang ◽  
Yuan Li ◽  
Jiaxing Li ◽  
Jie Yuan ◽  
Sheng Wang ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Environmental Stress ◽  
High Throughput ◽  
High Throughput Screening

scholarly journals Antiproliferative Activity of Hamigerone and Radicinol Isolated fromBipolaris papendorfii

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Periyasamy Giridharan ◽  
Shilpa A. Verekar ◽  
Akash R. Gohil ◽  
Prabhu Dutt Mishra ◽  
Amit Khanna ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Cancer Cells ◽  
High Throughput ◽  
Antiproliferative Activity ◽  
High Throughput Screening ◽  
Spectroscopic Data ◽  
Caspase 3 ◽  
Tumor Suppressor Protein ◽  
Natural Form ◽  
Tumor Suppressor Protein P53

Secondary metabolites from fungi organisms have extensive past and present use in the treatment of many diseases and serve as compounds of interest both in their natural form and as templates for synthetic modification. Through high throughput screening (HTS) and bioassay-guided isolation, we isolated two bioactive compounds hamigerone (1) and radicinol (2). These compounds were isolated from fungusBipolaris papendorfii, isolated from the rice fields of Dera, Himachal Pradesh, India. The structures of the compounds were established on the basis of spectroscopic data, namely, NMR (1H,13C, mass, and UV). Both compounds were found to be antiproliferative against different cancer cells. Furthermore we have also noted that both compounds showed increase in apoptosis by favorably modulating both tumor suppressor protein (p53) and antiapoptic protein (BCL-2), and in turn increase caspase-3 expression in cancer cells. This is the first report of these compounds from fungusBipolaris papendorfiiand their anticancer activity.

High-throughput screening program for botanical extracts

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
L Hingorani ◽  
NP Seeram ◽  
B Ebersole
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
Screening Program ◽  
Botanical Extracts

High throughput screening of microbial biodiversity for the discovery of novel cosmeceutical agents

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
K Georgousaki ◽  
N DePedro ◽  
AM Chinchilla ◽  
N Aliagiannis ◽  
F Vicente ◽  
...  
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
Microbial Biodiversity

High throughput screening to investigate Brazilian Cerrado biome plant extract bank chemical diversity

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
LS Espindola ◽  
RG Dusi ◽  
KR Gustafson ◽  
J McMahon ◽  
JA Beutler
Keyword(s):  
High Throughput ◽  
Plant Extract ◽  
High Throughput Screening ◽  
Chemical Diversity ◽  
Brazilian Cerrado ◽  
Cerrado Biome

High-throughput screening revealed a clinically relevant drug to induce sperm motility

2014 ◽  
Author(s):  
Clair Cochrane ◽  
Halil Ruso ◽  
Anthony Hope ◽  
Rosemary G Clarke ◽  
Christopher Barratt ◽  
...  
Keyword(s):  
Sperm Motility ◽  
High Throughput ◽  
High Throughput Screening
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