The role of solute transporters in aluminum toxicity and tolerance

2020 ◽  
Author(s):  
Debojyoti Kar ◽  
Ajar Anupam Pradhan ◽  
Sourav Datta
Keyword(s):  
Aluminum Toxicity ◽  
Solute Transporters

Citrate chelation as a potential mechanism against aluminum toxicity in cells: the role of calmodulin

1985 ◽  
Vol 63 (11) ◽  
pp. 1167-1175 ◽  
Author(s):  
Charles G. Suhayda ◽  
Alfred Haug
Keyword(s):  
Circular Dichroism ◽  
Conceptual Understanding ◽  
Aluminum Toxicity ◽  
Hydrophobic Surface ◽  
Native Structure ◽  
Calcium Calmodulin Dependent ◽  
Α Helix ◽  
Kinetics Of ◽  
Circular Dichroïsm

At a molar excess of [citrate]/[aluminum], this organic acid can protect calmodulin from aluminum binding if the metal is presented to the protein in stoichiometric micromolar quantities, as judged by fluorescence and circular dichroism spectroscopy. Similar citrate concentrations are also capable of fully restoring calmodulin's hydrophobic surface exposure to that of the native protein when calmodulin was initially damaged by aluminum binding. Fluoride anions are equally effective in restoring calmodulin's native structure as determined by fluorescence spectroscopy. Measurements of the kinetics of citrate-mediated aluminum removal also indicated that the metal ions are completely removed from calmodulin, consistent with results derived from atomic absorption experiments. On the other hand, results from circular dichroism studies indicated that citrate-mediated aluminum removal from calmodulin can only partially restore the α-helix content to that originally present in apocalmodulin or in calcium–calmodulin, dependent upon the absence or presence of calcium ions. The results that chelators like citrate can protect calmodulin from aluminum injury may provide a conceptual understanding of physiological observations regarding aluminum-tolerant plant species which are generally rich in certain organic acids.

scholarly journals Possible Role of Root Border Cells in Detection and Avoidance of Aluminum Toxicity

2001 ◽  
Vol 125 (4) ◽  
pp. 1978-1987 ◽  
Author(s):  
Susan C. Miyasaka ◽  
Martha C. Hawes
Keyword(s):  
Aluminum Toxicity ◽  
Border Cells ◽  
Root Border Cells

scholarly journals Nutritional and Structural Role of Silicon in Attenuating Aluminum Toxicity in Sugarcane Plants

Silicon ◽  
2021 ◽  
Author(s):  
Gilmar da Silveira Sousa Junior ◽  
Alexander Calero Hurtado ◽  
Jonas Pereira de Souza Junior ◽  
Renato de Mello Prado ◽  
Durvalina Maria Mathias dos Santos
Keyword(s):  
Aluminum Toxicity ◽  
Structural Role

scholarly journals Modulation the Neuro-toxicity Induced by Aluminum Chloride in Rats Using Beetroots and Broccli Extracts

2019 ◽  
pp. 1-18
Author(s):  
Abeer Ali Al-Balawi ◽  
Yousri Mohamed Ahmed ◽  
Ashwag Albukhari ◽  
Shareefa A. ALGhamdi ◽  
Mustafa A. Zeyadi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Aluminum Chloride ◽  
Aluminum Toxicity ◽  
Antioxidant Properties ◽  
Female Rats ◽  
Favorable Effect ◽  
Control Group ◽  
Root Extract ◽  
Reference Drug

Backgound: The generation of oxidative stress can be referred to Aluminium toxic effect in animals and humans. This study aimed to evaluate the role of broccoli (Br) and beetroot (Be) extarcts as antioxidant that prevents oxidative stress that associated with aluminum toxicity. Materials and Methods: Fifty Wister female rats were grouped into five groups (each 10 rats): Group 1: control group, administered drinking water only. Group 2: (Neurogenerative) which were induced by oral administration of aluminum chloride (20 mg/kg b.w) daily for one month. Group 3: Rats given aluminum chloride were treated with Rivastigmine (Ri) (1 mg/kg b.w) as a reference drug daily for five weeks. Group 4: Rats given aluminum chloride were treated with beet root extract (50 mg/kg b.w) daily for six weeks. Group 5. Rats given aluminum chloride were treated with broccoli extract (50 mg/kg b.w) daily for five weeks. Results: (AlCl3) group showed a significant increase in Ach level (P<0.05) and a non-significant change in DOP and NE levels compared to control. (AlCl3+Be) was non-significant (P˂0.05) change in Ach, DOP and NE levels compared to (AlCl3) group and showed a significant (P<0.05) increase in Ach level compared to control. (AlCl3+Br) showed a significant (P<0.05) increase in NE level and non-significant (P˂0.05) change in Ach and DOP levels compared to (AlCl3) group. (AlCl3+Ri) showed a significant (P<0.05) increase in Ach, DOP and NE levels compared to (AlCl3) group. Also, showed a significant (P<0.05) increase in Ach and NE compared to control. Conclusion: Neuroprotective role of broccoli in the present study which may result from its antioxidant properties due to its bioactive content such as glucosinolate, isothiocyanate, Sulforaphane, and flavonoids. Therefore, Broccoli can have a favorable effect on neurotoxicity due to their antioxidant and anti-inflammatory properties.

scholarly journals Dietary supplementation with probiotics regulates gut microbiota structure and function in Nile tilapia exposed to aluminum

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e6963 ◽  
Author(s):  
Leilei Yu ◽  
Nanzhen Qiao ◽  
Tianqi Li ◽  
Ruipeng Yu ◽  
Qixiao Zhai ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Nile Tilapia ◽  
Aluminum Toxicity ◽  
Experimental Period ◽  
Ion Concentration ◽  
Probiotic Supplementation ◽  
Aluminum Exposure ◽  
Bacterial Phyla ◽  
And Function

Backgrounds and aims Aluminum contamination of water is becoming increasingly serious and threatens the health status of fish. Lactobacillus plantarum CCFM639 was previously shown to be a potential probiotic for alleviation aluminum toxicity in Nile tilapia. Considering the significant role of the gut microbiota on fish health, it seems appropriate to explore the relationships among aluminum exposure, probiotic supplementation, and the gut microbiota in Nile tilapia and to determine whether regulation of the gut microbiota is related to alleviation of aluminum toxicity by a probiotic in Nile tilapia. Methods and results The tilapia were assigned into four groups, control, CCFM639 only, aluminum only, and aluminum + CCFM639 groups for an experimental period of 4 weeks. The tilapia in the aluminum only group were grown in water with an aluminum ion concentration of 2.73 mg/L. The final concentration of CCFM639 in the diet was 108 CFU/g. The results show that environmental aluminum exposure reduced the numbers of L. plantarum in tilapia feces and altered the gut microbiota. As the predominant bacterial phyla in the gut, the abundances of Bacteroidetes and Proteobacteria in aluminum-exposed fish were significantly elevated and lowered, respectively. At the genus level, fish exposed to aluminum had a significantly lower abundance of Deefgea, Plesiomonas, and Pseudomonas and a greater abundance of Flavobacterium, Enterovibrio, Porphyromonadaceae uncultured, and Comamonadaceae. When tilapia were exposed to aluminum, the administration of a probiotic promoted aluminum excretion through the feces and led to a decrease in the abundance of Comamonadaceae, Enterovibrio and Porphyromonadaceae. Notably, supplementation with a probiotic only greatly decreased the abundance of Aeromonas and Pseudomonas. Conclusion Aluminum exposure altered the diversity of the gut microbiota in Nile tilapia, and probiotic supplementation allowed the recovery of some of the diversity. Therefore, regulation of gut microbiota with a probiotic is a possible mechanism for the alleviation of aluminum toxicity in Nile tilapia.

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