Maternal periconceptional folic acid supplements use and fetus risk for limb defects

2021 ◽  
Author(s):  
Jie Zhang ◽  
Lei Jin ◽  
Di Wang ◽  
Cheng Wang ◽  
Mingkun Tong ◽  
...  
Keyword(s):  
Folic Acid ◽  
Limb Defects ◽  
Folic Acid Supplements

scholarly journals Health behaviours in 131,182 UK women planning pregnancy

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Beth McDougall ◽  
Kimberley Kavanagh ◽  
Judith Stephenson ◽  
Lucilla Poston ◽  
Angela C. Flynn ◽  
...  
Keyword(s):  
Folic Acid ◽  
Health Behaviours ◽  
Folic Acid Supplementation ◽  
Preconception Health ◽  
Younger Women ◽  
Healthy Pregnancy ◽  
Folic Acid Supplements ◽  
Weekly Physical Activity ◽  
The Uk ◽  
Changes Over Time

Abstract Background A woman’s health at the time of conception lays the foundation for a healthy pregnancy and the lifelong health of her child. We investigated the health behaviours of UK women planning pregnancy. Methods We analysed survey data from the ‘Planning for Pregnancy’ online tool (Tommy’s, UK). We described all women planning pregnancy and compared the frequency of non-adherence to preconception recommendations in women who had already stopped contraception (active planners) and those who had not (non-active planners). Results One hundred thirty-one thousand one hundred eighty-two women from across the UK were included, of whom 64.8% were actively planning pregnancy. Of the whole cohort, twenty percent were smokers and less than one third took folic acid supplements (31.5%). Forty two percent engaged in less than the recommended 150 min of weekly physical activity and only 53.3% consumed five portions of fruit or vegetables 4 days a week. Smokers were 1.87 times more likely to be active planners than non-smokers (95% CI 1.79–1.94), and women who took folic acid were 7 times more likely to be active planners (95% CI 6.97–7.59) compared to women who did not. Smoking, drug use and lack of folic acid supplementation were common in younger women and those who were underweight. Conclusions This unique survey of UK women has identified poor adherence to preconception recommendations in those planning pregnancies and supports the need for a greater public health focus on preconception health. This study provides a contemporary basis from which to inform preconception health advice and a benchmark to measure changes over time.

scholarly journals Utilization of preconception care and its impacts on health behavior changes among expectant couples in Shanghai, China

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Li Du ◽  
Xuena La ◽  
Liping Zhu ◽  
Hong Jiang ◽  
Biao Xu ◽  
...  
Keyword(s):  
Folic Acid ◽  
Child Health ◽  
Health Behavior ◽  
Pregnant Women ◽  
Preconception Care ◽  
Behavior Changes ◽  
Care Services ◽  
Folic Acid Supplements ◽  
Health Behavior Changes ◽  
And Child Health

Abstract Background Preconception care is an opportunity for detecting potential health risks in future parents and providing health behavior education to reduce morbidity and mortality for women and their offspring. Preconception care has been established in maternal and child health hospitals in Shanghai, China, which consists of health checkups, health education and counseling. This study investigated factors associated with the utilization of preconception care, and the role of preconception care on health behavior changes before conception among pregnant women and their partners. Methods A cross-sectional study was conducted among pregnant women at three maternal and child health hospitals in Shanghai. The participants were invited to complete a self-administered questionnaire on the utilization of preconception care and health behavioral changes before conception. Results Of the 948 recruited pregnant women, less than half (42.2%) reported that they had utilized preconception care before the current pregnancy. Unplanned pregnancy, unawareness of preconception care and already having a general physical examination were the main reasons for not attending preconception care. The two main sources of information about preconception care were local community workers and health professionals. Younger women and the multipara were less likely to utilize preconception care. Women who utilized preconception care were more likely to take folic acid supplements before conception [Adjusted Odds Ration (aOR) 3.27, 95% Confidence Interval (CI) 2.45–4.36, P < 0.0001]. The partners of pregnant women who had attended preconception care services were more likely to stop smoking [aOR 2.76, 95%CI 1.48–5.17, P = 0.002] and to stop drinking [aOR 2.13, 95%CI 1.03–4.39, P = 0.041] before conception. Conclusions Utilization of preconception care was demonstrated to be positively associated with preconception health behavior changes such as women taking folic acid supplements before pregnancy, their male partner stopping smoking and drinking before conception. Future studies are needed to explore barriers to utilizing preconception care services and understand the quality of the services. Strategies of promoting preconception care to expectant couples, especially to young and multipara women, should be developed to further improve the utilization of the services at the community level.

scholarly journals Prenatal Folic Acid Supplements and Offspring’s Autism Spectrum Disorder: A Meta-analysis and Meta-regression

2021 ◽  
Author(s):  
Xian Liu ◽  
Mingyang Zou ◽  
Caihong Sun ◽  
Lijie Wu ◽  
Wen-Xiong Chen
Keyword(s):  
Folic Acid ◽  
Meta Analysis ◽  
Folic Acid Supplementation ◽  
Autism Spectrum ◽  
Acid Supplementation ◽  
Daily Amount ◽  
Folic Acid Supplements ◽  
Meta Regression ◽  
Spectrum Disorders ◽  
Reduced Risk

AbstractWe systematically reviewed the evidence on the association between maternal folic acid supplementation and the risk of offspring’s autism spectrum disorders (ASD). A total of 10 studies with 23 sub-studies (9795 ASD cases) were included. Folic acid supplementation during early pregnancy was associated with a lower risk of offspring’s ASD [OR 0.57, 95% CI 0.41–0.78]. The consumption of a daily amount of at least 400 μg folic acid from dietary sources and supplements, was associated with a reduced risk of offspring ASD [OR 0.55, 95% CI 0.36–0.83]. Critical effective maternal folic acid supplementation strategies, such as intake timing and intake dosage, may aid the reduction in the risk of offspring ASD. This meta-analysis provided new insights for the prevention of offspring’s ASD.

scholarly journals Use of high doses of folic acid supplements in pregnant women in Spain: an INMA cohort study

BMJ Open ◽  
2015 ◽  
Vol 5 (11) ◽  
pp. e009202 ◽  
Author(s):  
Eva María Navarrete-Muñoz ◽  
Desirée Valera-Gran ◽  
Manoli García de la Hera ◽  
Daniel Gimenez-Monzo ◽  
Eva Morales ◽  
...  
Keyword(s):  
Cohort Study ◽  
Folic Acid ◽  
Pregnant Women ◽  
Folic Acid Supplements ◽  
High Doses

Folic Acid Supplements and Perinatal Mortality in China

2021 ◽  
Author(s):  
Nan Li ◽  
Xiaojing Liu ◽  
Hang An ◽  
Zhiwen Li ◽  
Le Zhang ◽  
...  
Keyword(s):  
Folic Acid ◽  
Perinatal Mortality ◽  
Folic Acid Supplements
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