Potassium ion channel gene family provides new insights into powdery mildew responses in Triticum aestivum

2021 ◽  
Author(s):  
Y.F. Hu ◽  
P.L. Xia ◽  
H.L. Niu ◽  
X.Y. Wu ◽  
S.J. Gong ◽  
...  
Keyword(s):  
Triticum Aestivum ◽  
Powdery Mildew ◽  
Ion Channel ◽  
Gene Family ◽  
Potassium Ion ◽  
Potassium Ion Channel ◽  
Channel Gene ◽  
Ion Channel Gene

Association between variation in the human KCNJ10 potassium ion channel gene and seizure susceptibility

2004 ◽  
Vol 58 (2-3) ◽  
pp. 175-183 ◽  
Author(s):  
R.J Buono ◽  
F.W Lohoff ◽  
T Sander ◽  
M.R Sperling ◽  
M.J O’Connor ◽  
...  
Keyword(s):  
Ion Channel ◽  
Potassium Ion ◽  
Seizure Susceptibility ◽  
Potassium Ion Channel ◽  
Channel Gene ◽  
Ion Channel Gene

Myrsinane and related diterpenes from Euphorbia falcata with selective potassium ion channel activity

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
A Vasas ◽  
P Orvos ◽  
L Tálosi ◽  
P Forgo ◽  
G Pinke ◽  
...  
Keyword(s):  
Ion Channel ◽  
Potassium Ion ◽  
Channel Activity ◽  
Potassium Ion Channel

scholarly journals The study of sodium and potassium channel gene single-nucleotide variation significance in non-mechanical forms of epilepsy

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Ozada Khamdiyeva ◽  
Zhanerke Tileules ◽  
Gulminyam Baratzhanova ◽  
Anastassiya Perfilyeva ◽  
Leyla Djansugurova
Keyword(s):  
Ion Channel ◽  
Potassium Channel ◽  
De Novo ◽  
Potassium Ion ◽  
Dravet Syndrome ◽  
De Novo Mutations ◽  
Single Nucleotide ◽  
Channel Gene ◽  
Sodium And Potassium ◽  
Potassium Channel Gene

Abstract Background Epilepsy is one of the most common and heterogeneous neurological diseases. The main clinical signs of the disease are repeated symptomatic or idiopathic epileptic seizures of both convulsive and non-convulsive nature that develop against a background of lost or preserved consciousness. The genetic component plays a large role in the etiology of idiopathic forms of epilepsy. The study of the molecular genetic basis of neurological disorders has led to a rapidly growing number of gene mutations known to be involved in hereditary ion channel dysfunction. The aim of this research was to evaluate the involvement of single-nucleotide variants that modify the function of genes (SCN1A, KCNT1, KCNTС1, and KCNQ2) encoding sodium and potassium ion channel polypeptides in the development of epilepsy. Results De novo mutations in the sodium channel gene SCN1A c.5347G>A (p. Ala1783Thr) were detected in two patients with Dravet syndrome, with a deletion in exon 26 found in one. Three de novo mutations in the potassium channel gene KCNT1 c.2800G>A (p. Ala934Thr), were observed in two patients with temporal lobe epilepsy (TLE) and one patient with residual encephalopathy. Moreover, a control cohort matched to the case cohort did not reveal any SNVs among conditionally healthy individuals, supporting the pathogenic significance of the studied SNVs. Conclusion Our results are supported by literature data showing that the sodium ion channel gene SCN1A c.5347G>A mutation may be involved in the pathogenesis of Dravet syndrome. We also note that the c.2800G>A mutation in the potassium channel gene KCNT1 can cause not only autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) but also other forms of epilepsy. To treat pathogenetic mutations that accelerate the function of sodium and potassium ion channels, we recommend ion channel blockade drug therapy.

scholarly journals Ion Channel Gene Expression in Lung Adenocarcinoma: Potential Role in Prognosis and Diagnosis

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e86569 ◽  
Author(s):  
Jae-Hong Ko ◽  
Wanjun Gu ◽  
Inja Lim ◽  
Hyoweon Bang ◽  
Eun A. Ko ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Adenocarcinoma ◽  
Ion Channel ◽  
Potential Role ◽  
Channel Gene ◽  
Ion Channel Gene
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