scholarly journals Analgesic Efficacy and Mode of Action of a Selective Small Molecule Angiotensin II Type 2 Receptor Antagonist in a Rat Model of Prostate Cancer-Induced Bone Pain

Pain Medicine ◽  
2014 ◽  
Vol 15 (1) ◽  
pp. 93-110 ◽  
Author(s):  
Arjun Muralidharan ◽  
Bruce D. Wyse ◽  
Maree T. Smith
Keyword(s):  
Prostate Cancer ◽  
Angiotensin Ii ◽  
Receptor Antagonist ◽  
Small Molecule ◽  
Rat Model ◽  
Mode Of Action ◽  
Bone Pain ◽  
Analgesic Efficacy

Analgesic efficacy of small-molecule angiotensin II type 2 receptor antagonists in a rat model of antiretroviral toxic polyneuropathy

2014 ◽  
Vol 25 (2) ◽  
pp. 137-146 ◽  
Author(s):  
Maree T. Smith ◽  
Tanya Lau ◽  
Victoria C.J. Wallace ◽  
Bruce D. Wyse ◽  
Andrew S.C. Rice
Keyword(s):  
Angiotensin Ii ◽  
Small Molecule ◽  
Rat Model ◽  
Analgesic Efficacy ◽  
Receptor Antagonists

scholarly journals Characterization of a rat model of metastatic prostate cancer bone pain

2010 ◽  
pp. 213 ◽  
Author(s):  
Gurmit Singh ◽  
De Ciantis ◽  
Henry ◽  
Yashpal
Keyword(s):  
Prostate Cancer ◽  
Rat Model ◽  
Bone Pain ◽  
Metastatic Prostate Cancer

Angiotensin II type 2 receptor gene transfer elicits cardioprotective effects in an angiotensin II infusion rat model of hypertension

2004 ◽  
Vol 19 (3) ◽  
pp. 255-261 ◽  
Author(s):  
Beverly L. Falcón ◽  
Jillian M. Stewart ◽  
Erick Bourassa ◽  
Michael J. Katovich ◽  
Glenn Walter ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Gene Transfer ◽  
Cardiac Hypertrophy ◽  
Rat Model ◽  
Lentiviral Vector ◽  
Receptor Gene ◽  
Left Ventricular ◽  
Heart Weight ◽  
Sprague Dawley

The role of the angiotensin II type 2 receptor (AT2R) in cardiovascular physiology remains elusive. We have developed an in vivo lentiviral vector-mediated gene transfer system to study the physiological functions of the AT2R. Our objectives in this study were to determine whether the AT2R influences cardiac hypertrophy and myocardial and perivascular fibrosis in a nongenetic rat model of hypertension. Lentiviral vector containing the AT2R or saline was injected intracardially in 5-day-old Sprague-Dawley rats. This resulted in a persistent overexpression of the AT2R in cardiac tissues. At 15 wk of age, animals were infused with either 200 ng·kg−1·min−1 of angiotensin II or saline by implantation of a 4-wk osmotic minipump. This resulted in an increase in blood pressure (BP) that reached maximal by 2 wk of treatment and was associated with a 123% increase in left ventricular wall thickness (LVWT) and a 129% increase in heart weight to body weight ratios (HW/BW). In addition, the increase in cardiac hypertrophy was associated with a 300% and 158% increase in myocardial and perivascular fibrosis, respectively. Cardiac transduction of the AT2R resulted in an 85% attenuation of LVWT, 91% attenuation of HW/BW, and a 43% decrease in myocardial fibrosis induced by angiotensin infusion. These improvements in cardiac pathology were observed in the absence of attenuation of high BP. Thus our observations indicate that long-term expression of the AT2R in the heart attenuates cardiac hypertrophy and fibrosis in a nongenetic rat model of hypertension.

Sign in / Sign up

Export Citation Format

Share Document