scholarly journals Analgesic Efficacy and Safety of Medical Therapy Alone vs Combined Medical Therapy and Extraoral Glossopharyngeal Nerve Block in Glossopharyngeal Neuralgia

Pain Medicine ◽  
2013 ◽  
Vol 14 (1) ◽  
pp. 93-102 ◽  
Author(s):  
Preet M. Singh ◽  
Maya Dehran ◽  
Virender K. Mohan ◽  
Anjan Trikha ◽  
Manpreet Kaur
Keyword(s):  
Nerve Block ◽  
Medical Therapy ◽  
Analgesic Efficacy ◽  
Glossopharyngeal Nerve ◽  
Glossopharyngeal Neuralgia ◽  
Efficacy And Safety

Glossopharyngeal Nerve Block for Idiopathic Glossopharyngeal Neuralgia: A case report

1998 ◽  
Vol 34 (2) ◽  
pp. 439 ◽  
Author(s):  
Byung Hoon Yoo ◽  
Ji Young Son ◽  
Kee Hyek Hong ◽  
Dong Yeup Sin
Keyword(s):  
Case Report ◽  
Nerve Block ◽  
Glossopharyngeal Nerve ◽  
Glossopharyngeal Neuralgia

scholarly journals Glossopharyngeal Neuralgia: An Approach to Diagnosis and Management

2020 ◽  
Author(s):  
Vasudha Goel
Keyword(s):  
Quality Of Life ◽  
Medical Therapy ◽  
Deleterious Effect ◽  
Sensory Nerve ◽  
Review Article ◽  
Glossopharyngeal Nerve ◽  
Glossopharyngeal Neuralgia ◽  
Nerve Blocks ◽  
Clinical Vignettes

Glossopharyngeal neuralgia is an uncommon facial syndrome with significant deleterious effect on the quality of life. The glossopharyngeal nerve is predominantly a sensory nerve with a limited number of motor and autonomic fibers. The central causes of glossopharyngeal neuralgia are commonly treated with neurosurgical interventions. Medical therapy and nerve blocks are predominantly used to treat peripheral causes of glossopharyngeal neuralgia. In this review article, we present clinical vignettes and describe practical aspects of intra-oral, extra-oral, and peripheral techniques to block the glossopharyngeal nerve. The glossopharyngeal nerve blocks should be performed in a monitored setting due to the potential for adverse complications.

scholarly journals Evaluation on immediate analgesic efficacy and safety of Kai-Hou-Jian spray (children’s type) in treating sore throat caused by acute pharyngitis and tonsillitis in children: study protocol for a randomized controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Yan-ning Ma ◽  
Cheng-liang Zhong ◽  
Si-yuan Hu ◽  
Qiu-han Cai ◽  
Sheng-xuan Guo
Keyword(s):  
Clinical Trial ◽  
Sore Throat ◽  
Controlled Trial ◽  
Analgesic Efficacy ◽  
Effective Rate ◽  
Efficacy And Safety ◽  
Double Blind ◽  
Acute Pharyngitis ◽  
Randomized Controlled ◽  
Parallel Group

Abstract Background Acute pharyngitis and tonsillitis are common respiratory diseases for which children seek medical care. Their main clinical manifestation is sore throat which interferes with patients’ quality of life. However, there is no proven effective or safe method to treat it. It is necessary to find an excellent strategy to reduce sore throat and reduce the burden of acute illness. We designed the randomized controlled trial with the characteristics of traditional Chinese medicine (TCM) to determine the clinical positioning of Kai-Hou-Jian spray (children’s type) (KHJS) through evidence-based research. This trial aims to evaluate the immediate analgesic efficacy of KHJS on sore throat caused by acute pharyngitis and tonsillitis (wind-heat syndrome/heat exuberance in lung and stomach syndrome) in children and to observe its safety. Methods/design This is a prospective, multicenter, randomized, double-blind, parallel-group, placebo-controlled trial. It will include 240 children with acute pharyngitis/tonsillitis from 7 study sites across China. All participants are randomly assigned to two parallel treatment groups, one with KHJS and the other with placebo sprays, for 5 consecutive days. The primary outcome is the time of analgesic onset. Secondary outcomes include duration of analgesic effect, area under time curve of 0–3 h Wong-Baker FACES Pain Rating Scale (WBS) score (AUC0-3 h), rate of analgesic onset, rate of disappearance of sore throat, changes of WBS score (in days), effective rate of pharyngeal signs, and effective rate of TCM syndrome. The incidence of adverse events during the trial is the primary safety outcome. In addition, vital signs and laboratory tests before and after medication are monitored. Discussion To our knowledge, this will be the first clinical trial to explore the immediate analgesic efficacy of a Chinese patent medicine spray for acute pharyngitis/tonsillitis induced sore throat in children in a multicenter, randomized, double-blinded, parallel-group, placebo-controlled manner. Not only might it prove the efficacy and safety of KHJS in the treatment of sore throat caused by acute pharyngitis/tonsillitis in children, but it might also provide evidence for the treatment of acute sore throat with Chinese herbal medicine. Trial registration A multicenter, randomized, double-blind, very low-dose, parallel controlled trial for the immediate analgesic effect and safety of Kai-Hou- Jian spray (children's type) in the treatment of sore throat caused by acute pharyngitis and tonsillitis in children. Chinese Clinical Trial Registry ChiCTR2000031599. Registered on 5 April 2020

scholarly journals ANalgesic Efficacy and safety of MOrphiNe versus methoxyflurane in patients with acute myocardial infarction: the rationale and design of the ANEMON-SIRIO 3 study: a multicentre, open-label, phase II, randomised clinical trial

BMJ Open ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. e043330
Author(s):  
Aldona Kubica ◽  
Agata Kosobucka ◽  
Piotr Niezgoda ◽  
Piotr Adamski ◽  
Katarzyna Buszko ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Analgesic Efficacy ◽  
Randomised Clinical Trial ◽  
Ethical Standards ◽  
Loading Dose ◽  
Efficacy And Safety ◽  
Open Label ◽  
Analgesic Treatment ◽  
Open Label Phase ◽  
St Elevation

IntroductionThe unfavourable influence of morphine on the pharmacokinetics of ticagrelor resulting in weaker and retarded antiplatelet effect in patients with acute coronary syndrome (ACS) has been previously shown. Replacing morphine with methoxyflurane, a potent, non-opioid analgesic agent, that does not weaken or delay the effect of antiplatelet agents may improve the clinical efficacy of treatment of patients with ACS.MethodsThe ANEMON-SIRIO 3 study was designed as a multicentre, open-label, phase II, randomised clinical trial aimed to test the analgesic efficacy and safety of methoxyflurane in patients with ACS. The study population will comprise patients with ST-elevation myocardial infarction or non-ST-elevation ACS admitted to the study centres with typical chest pain requiring analgesic treatment. Before percutaneous coronary intervention (PCI) for the patients with index ACS will be randomly assigned in 1:1 ratio to receive methoxyflurane administered by inhalation, or to obtain morphine administered intravenously. Analgesic treatment will be followed by 300 mg loading dose of aspirin and 180 mg loading dose of ticagrelor. Patients will be assessed with regard to pain intensity according to the Numeric Pain Rating Scale at baseline, 3 min after study drug administration and immediately after PCI. Moreover, patients will be actively monitored with regard to the occurrence of side effects of evaluated therapies, as well as adverse events that may be related to insufficient platelet inhibition (no-reflow phenomenon assessed immediately after PCI, administration of GPIIb/IIIa inhibitors during PCI, acute stent thrombosis).Ethics and disseminationThe study will be conducted in six Polish clinical centres from the beginning of in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.Trial registration detailsClinicalTrials.gov, NCT04476173.

scholarly journals Intrathecal betamethasone for cancer pain: A study of its analgesic efficacy and safety

2018 ◽  
Vol 63 (5) ◽  
pp. 659-667
Author(s):  
Hitoshi Taguchi ◽  
Keiko Oishi ◽  
Koh Shingu ◽  
Hideo Matsumoto ◽  
Munehiro Masuzawa
Keyword(s):  
Cancer Pain ◽  
Analgesic Efficacy ◽  
Efficacy And Safety
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