Mitochondrial ribosomal protein S9M is involved in male gametogenesis and seed development in Arabidopsis

Plant Biology ◽  
2020 ◽  
Vol 22 (4) ◽  
pp. 655-667 ◽  
Author(s):  
C. Lu ◽  
Z. Xie ◽  
F. Yu ◽  
L. Tian ◽  
X. Hao ◽  
...  
Keyword(s):  
Ribosomal Protein ◽  
Seed Development ◽  
Male Gametogenesis ◽  
Mitochondrial Ribosomal Protein

scholarly journals Maize Dek44 Encodes Mitochondrial Ribosomal Protein L9 and Is Required for Seed Development

2019 ◽  
Vol 180 (4) ◽  
pp. 2106-2119 ◽  
Author(s):  
Weiwei Qi ◽  
Lei Lu ◽  
Shengchan Huang ◽  
Rentao Song
Keyword(s):  
Ribosomal Protein ◽  
Seed Development ◽  
Mitochondrial Ribosomal Protein ◽  
Ribosomal Protein L9

scholarly journals Discoordinate expression of the yeast mitochondrial ribosomal protein MRP1.

1990 ◽  
Vol 265 (13) ◽  
pp. 7449-7454
Author(s):  
H Dang ◽  
G Franklin ◽  
K Darlak ◽  
A F Spatola ◽  
S R Ellis
Keyword(s):  
Ribosomal Protein ◽  
Mitochondrial Ribosomal Protein

scholarly journals Mutations in the mitochondrial ribosomal protein MRPS22 lead to primary ovarian insufficiency

2018 ◽  
Vol 27 (11) ◽  
pp. 1913-1926 ◽  
Author(s):  
Anlu Chen ◽  
Dov Tiosano ◽  
Tulay Guran ◽  
Hagit N Baris ◽  
Yavuz Bayram ◽  
...  
Keyword(s):  
Ribosomal Protein ◽  
Primary Ovarian Insufficiency ◽  
Ovarian Insufficiency ◽  
Mitochondrial Ribosomal Protein

scholarly journals Cell stemness is maintained upon concurrent expression of RB and the mitochondrial ribosomal protein S18-2

2020 ◽  
Vol 117 (27) ◽  
pp. 15673-15683
Author(s):  
Muhammad Mushtaq ◽  
Larysa Kovalevska ◽  
Suhas Darekar ◽  
Alexandra Abramsson ◽  
Henrik Zetterberg ◽  
...  
Keyword(s):  
Stem Cell ◽  
Ribosomal Protein ◽  
Severe Combined Immunodeficiency ◽  
Ectopic Expression ◽  
Embryonic Stem ◽  
Ring Finger ◽  
Histone H2a ◽  
Mitochondrial Ribosomal Protein ◽  
Primary Mouse

Stemness encompasses the capability of a cell for self-renewal and differentiation. The stem cell maintains a balance between proliferation, quiescence, and regeneration via interactions with the microenvironment. Previously, we showed that ectopic expression of the mitochondrial ribosomal protein S18-2 (MRPS18-2) led to immortalization of primary fibroblasts, accompanied by induction of an embryonic stem cell (ESC) phenotype. Moreover, we demonstrated interaction between S18-2 and the retinoblastoma-associated protein (RB) and hypothesized that the simultaneous expression of RB and S18-2 is essential for maintaining cell stemness. Here, we experimentally investigated the role of S18-2 in cell stemness and differentiation. Concurrent expression of RB and S18-2 resulted in immortalization ofRb1−/−primary mouse embryonic fibroblasts and in aggressive tumor growth in severe combined immunodeficiency mice. These cells, which express both RB and S18-2 at high levels, exhibited the potential to differentiate into various lineages in vitro, including osteogenic, chondrogenic, and adipogenic lineages. Mechanistically, S18-2 formed a multimeric protein complex with prohibitin and the ring finger protein 2 (RNF2). This molecular complex increased the monoubiquitination of histone H2ALys119, a characteristic trait of ESCs, by enhanced E3-ligase activity of RNF2. Furthermore, we found enrichment of KLF4 at theS18-2promoter region and that theS18-2expression is positively correlated withKLF4levels. Importantly, knockdown of S18-2 in zebrafish larvae led to embryonic lethality. Collectively, our findings suggest an important role for S18-2 in cell stemness and differentiation and potentially also in cancerogenesis.

scholarly journals Antenatal mitochondrial disease caused by mitochondrial ribosomal protein (MRPS22) mutation

2007 ◽  
Vol 44 (12) ◽  
pp. 784-786 ◽  
Author(s):  
A Saada ◽  
A Shaag ◽  
S Arnon ◽  
T Dolfin ◽  
C Miller ◽  
...  
Keyword(s):  
Ribosomal Protein ◽  
Mitochondrial Disease ◽  
Mitochondrial Ribosomal Protein

scholarly journals Silencing of the Nuclear RPS10 Gene Encoding Mitochondrial Ribosomal Protein Alters Translation in Arabidopsis Mitochondria

2013 ◽  
Vol 25 (5) ◽  
pp. 1855-1867 ◽  
Author(s):  
Malgorzata Kwasniak ◽  
Pawel Majewski ◽  
Renata Skibior ◽  
Aleksandra Adamowicz ◽  
Malgorzata Czarna ◽  
...  
Keyword(s):  
Ribosomal Protein ◽  
Gene Encoding ◽  
Mitochondrial Ribosomal Protein
Sign in / Sign up

Export Citation Format

Share Document