SMARCB1(INI1)‐deficient sinonasal adenocarcinoma: Report of a case previously diagnosed as high‐grade non‐intestinal‐type sinonasal adenocarcinoma

2021 ◽  
Author(s):  
Yu‐Ju Su ◽  
Yi‐Hsuan Lee ◽  
Min‐Shu Hsieh
Keyword(s):  
Intestinal Type ◽  
High Grade ◽  
Sinonasal Adenocarcinoma

scholarly journals Nasopharyngeal non-intestinal-type adenocarcinoma: a case report and updated review of the literature

2017 ◽  
Vol 24 (1) ◽  
pp. 55 ◽  
Author(s):  
C. Jain ◽  
L. Caulley ◽  
K.I. Macdonald ◽  
B. Purgina ◽  
C.K. Lai ◽  
...  
Keyword(s):  
Radiation Treatment ◽  
Rare Condition ◽  
Intestinal Type ◽  
World Health ◽  
Primary Radiation ◽  
High Grade ◽  
Rare Tumours ◽  
Intestinal Type Adenocarcinoma ◽  
Health Organization ◽  
Nasopharyngeal Masses

Background Non-intestinal-type adenocarcinoma is a malignancy traditionally found in the sinonasal cavity. To our knowledge, this case is the first reported of this rare condition originating in the nasopharynx.Case Presentation A 67-year-old woman with nasopharyngeal non-intestinal-type adenocarcinoma, with an accompanying parapharyngeal mass received primary radiation treatment for both lesions. Her tumour subsequently persisted, with a concomitant conversion in pathology from a low- to a high-grade malignancy.Results Non-intestinal-type and intestinal-type adenocarcinomas of the nasopharynx are extremely rare tumours and do not appear in the World Health Organization classification system. We review the pathophysiologic features of these malignancies and propose modifications to the current classification system.Conclusions Non-intestinal-type adenocarcinoma should be included in the differential diagnosis of nasopharyngeal masses. In our experience, this tumour in this location showed a partial response to primary radiation but later converted from a low- to a high-grade adenocarcinoma.

CDX2 Is a Useful Marker of Intestinal-Type Differentiation: A Tissue Microarray–Based Study of 629 Tumors From Various Sites

2005 ◽  
Vol 129 (9) ◽  
pp. 1100-1105 ◽  
Author(s):  
Lindsey B. De Lott ◽  
Carl Morrison ◽  
Saul Suster ◽  
David E. Cohn ◽  
Wendy L. Frankel
Keyword(s):  
Squamous Cell ◽  
Signet Ring Cell ◽  
Squamous Cell Carcinomas ◽  
Intestinal Type ◽  
High Grade ◽  
Poorly Differentiated Neuroendocrine Carcinoma ◽  
Poorly Differentiated ◽  
Lung Adenocarcinomas ◽  
Colorectal Adenocarcinomas ◽  
Neuroendocrine Carcinomas

Abstract Context.—CDX2, a critical nuclear transcription factor for intestinal development, is expressed in intestinal epithelium and adenocarcinomas. Objectives.—To determine if CDX2 is a useful marker for intestinal-type differentiation and to correlate tumor histology with CDX2 staining in colorectal adenocarcinomas. Design.—Tissue microarrays from 71 colorectal adenocarcinomas, 31 hepatocellular carcinomas, 47 lung adenocarcinomas, 55 squamous cell carcinomas of the lung, 69 neuroendocrine carcinomas of the lung and 43 of the pancreas, 57 pancreatic adenocarcinomas, and 256 endometrial adenocarcinomas were stained with antibody against CDX2. Results.—CDX2 staining was positive in 51 (71.8%) of 71 colorectal cancers, including 38 (74.5%) of 51 well- or moderately differentiated tumors and 13 (65.0%) of 20 high-grade tumors. Of the high-grade tumors, 5 (71.4%) of 7 mucinous, 3 (100%) of 3 signet ring cell, and 5 (50.0%) of 10 poorly differentiated tumors were positive. Other tumors showing occasional CDX2 staining included 1 of 30 well- or moderately differentiated neuroendocrine carcinomas of the lung and 2 of 43 from the pancreas, 1 of 47 lung adenocarcinomas, 3 of 57 pancreatic adenocarcinomas, and 15 of 256 endometrial carcinomas. Hepatocellular, poorly differentiated neuroendocrine carcinoma of the lung and squamous cell carcinomas of the lung were not immunoreactive for CDX2. Conclusions.—CDX2 is a useful marker for intestinal-type differentiation, is rarely seen in tumors from the other sites evaluated, and may be useful in determining the site of origin for some metastatic tumors. However, CDX2 is not a sensitive marker for poorly differentiated colorectal carcinoma.

scholarly journals Recurrent DNA copy number alterations in intestinal-type sinonasal adenocarcinoma

2016 ◽  
Vol 54 (3) ◽  
pp. 278-286
Author(s):  
J. Perez-Escuredo ◽  
A. Lopez-Hernandez ◽  
M. Costales ◽  
F. Lopez ◽  
S.P. Ares ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Copy Number ◽  
Genetic Alterations ◽  
Intestinal Type ◽  
Dust Exposure ◽  
Copy Number Alterations ◽  
A Genome ◽  
Sinonasal Adenocarcinoma ◽  
Gains And Losses ◽  
Microarray Cgh

Background: Intestinal-type sinonasal adenocarcinoma (ITAC) is a rare tumour related to occupational wood dust exposure. Few studies have described recurrent genetic changes on a genome-wide scale. The aim of this study was to obtain a high resolution map of recurrent genetic alterations in ITAC. Material and methods: Copy number alterations were evaluated by microarray CGH and MLPA in 37 primary tumours. The results were correlated with pathological characteristics and clinical outcome. Results: Microarray CGH identified the following recurrent aberrations, in descending order: gains at 5p15 (22 cases, 60%), 8q24 (21 cases, 57%), 20q13 (20 cases, 54%), 20q11, and 8q21 (19 cases, 51%), 20p13, and 7p11 (16 cases, 43%), and losses at 5q11-qter, 8p12-pter, and 18q12-23 (15 cases, 40%), and 17p13, and 19p13 (13 cases, 35%). MLPA analysis confirmed this global pattern of gains and losses. Chromosomal loss at 4q32-ter and gains at 1q22, 6p22 and 3q29, as well as deletion of TIMP2 and CRK correlated with unfavourable clinical outcome. Conclusion: ITACs have a unique pattern of chromosomal abnormalities. The four different histological subtypes of ITAC appeared genetically similar. Four chromosomal gains and losses and two specific genes showed prognostic value and may be involved in tumour progression.

P18 Clinical management of intestinal-type sinonasal adenocarcinoma: A monoinstitutional experience of 165 cases

Oral Oncology ◽  
2015 ◽  
Vol 51 (5) ◽  
pp. e48
Author(s):  
M. Costales ◽  
F. López ◽  
B. Vivanco ◽  
C. García-Inclán ◽  
A. López-Hernández ◽  
...  
Keyword(s):  
Clinical Management ◽  
Intestinal Type ◽  
Sinonasal Adenocarcinoma

scholarly journals Establishment and genetic characterization of an immortal tumor cell line derived from intestinal-type sinonasal adenocarcinoma

2011 ◽  
Vol 34 (1) ◽  
pp. 23-31 ◽  
Author(s):  
Jhudit Pérez-Escuredo ◽  
Jorge García Martínez ◽  
Cristina García-Inclán ◽  
Blanca Vivanco ◽  
María Costales ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Line ◽  
Genetic Characterization ◽  
Tumor Cell Line ◽  
Intestinal Type ◽  
Sinonasal Adenocarcinoma

scholarly journals A case of chemotherapy-resistant intestinal-type sinonasal adenocarcinoma treated by gamma knife radiosurgery

2017 ◽  
Vol 10 ◽  
pp. 135-137
Author(s):  
Andres M. Alvarez-Pinzon ◽  
Jose E. Valerio ◽  
Beatriz E. Amendola ◽  
Devi Lakhlani ◽  
Alan A. Stein ◽  
...  
Keyword(s):  
Gamma Knife ◽  
Gamma Knife Radiosurgery ◽  
Intestinal Type ◽  
Sinonasal Adenocarcinoma

Intestinal-type sinonasal adenocarcinoma: a sporadic case

1996 ◽  
Vol 110 (8) ◽  
pp. 805-810 ◽  
Author(s):  
Andrej Böör ◽  
Ivan Jurkovič ◽  
Katarína Dudríková ◽  
Vojtech Kavečanský ◽  
Imrich Friedmann
Keyword(s):  
Nasal Septum ◽  
Chromogranin A ◽  
Sporadic Case ◽  
Intestinal Type ◽  
Wood Dust ◽  
Tubular Adenocarcinoma ◽  
Dust Inhalation ◽  
Sinonasal Adenocarcinoma ◽  
History Of ◽  
Columnar Cells

AbstractA sporadic case of the intestinal-type sinonasal adenocarcinoma is described. The patient was a comparatively young 33-year-old woman employed as a senior biochemical scientific technologist for several years. The light microscopical pattern was that of a papillary-tubular adenocarcinoma with areas of more solid mucinous elements in the deeper parts of the neoplasm. The neoplasm had invaded the nasal septum and reached the left orbit invading the left ethmoidal sinus. The glands were lined by columnar cells with elongated spindle-shaped nuclei and the cells expressed cytokeratin, carcinoembryonic antigen (CEA), Chromogranin A, gastrin and serotonin but not neurone-specific enolase (NSE) nor synaptophysin. Neurosecretory granules were present. There was no history of wood dust inhalation and her exposure to chemicals is of some interest but had probably little or no role in the causation of this neoplasm.

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