scholarly journals A case of an atypical teratoid/rhabdoid tumor with distinctive histology in the pineal region in an adult patient

2021 ◽  
Author(s):  
Masatomo Doi ◽  
Junki Koike ◽  
Yasuyuki Yoshida ◽  
Hisao Nakamura ◽  
Motohiro Chosokabe ◽  
...  
Keyword(s):  
Adult Patient ◽  
Pineal Region ◽  
Rhabdoid Tumor ◽  
Atypical Teratoid Rhabdoid Tumor ◽  
Atypical Teratoid

scholarly journals Primary atypical teratoid/rhabdoid tumor of the spine in an adult patient

2016 ◽  
Vol 7 (1) ◽  
pp. 27 ◽  
Author(s):  
HaSon Nguyen ◽  
Luyuan Li ◽  
Mohit Patel ◽  
Ninh Doan ◽  
Abhishiek Sharma ◽  
...  
Keyword(s):  
Adult Patient ◽  
Rhabdoid Tumor ◽  
Atypical Teratoid Rhabdoid Tumor ◽  
Atypical Teratoid

scholarly journals ATRT-10. ATYPICAL TERATOID/RHABDOID TUMOR OF THE PINEAL REGION IN A PEDIATRIC PATIENT

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii277-iii277
Author(s):  
Carlos Almeida ◽  
Bruna Minniti Mançano ◽  
Marcus Matsushita ◽  
Stephanie Previdelli ◽  
Marina Lopes Lamim ◽  
...  
Keyword(s):  
Pediatric Patient ◽  
Pediatric Population ◽  
Obstructive Hydrocephalus ◽  
Malignant Neoplasm ◽  
Pineal Region ◽  
Rhabdoid Tumor ◽  
Atypical Teratoid Rhabdoid Tumor ◽  
Atypical Teratoid ◽  
Magnetic Resonance Imaging Mri ◽  
One Year

Abstract BACKGROUND Atypical teratoid/rhabdoid tumor (ATRT) is a malignant neoplasm of the central nervous system and corresponds to 1.5% of all intracranial tumors. Mainly affects children under three years of age and shows aggressive behavior (most pediatric patients succumb to their disease within a year after the initial diagnosis, despite the treatment performed). Its place of occurrence in children is preferably in the posterior fossa, and it is rare to appear in other regions. There are only seven patients with ATRT reported on literature; all of them are adults. We present the case of a pediatric patient with a tumor in the pineal region diagnosed as ATRT. CASE REPORT: Three-year-old female patient admitted with occipital headache, vomiting, and seizure. Magnetic resonance imaging (MRI) showed obstructive hydrocephalus secondary to a solid-cystic lesion located at the pineal region that was 3.0 x 3.0 x 3.5 cm in size. Spine MRI did not reveal leptomeningeal spreading. We performed an occipital transtentorial approach to achieve the best safe resection possible, and a ventriculoperitoneal shunt. Histological examination revealed ATRT. The patient received adjuvant treatment with radiotherapy and chemotherapy according to the “Head Start” protocol. One year after the surgery, MRI did not identify any remaining lesion. CONCLUSION ATRT is an aggressive and rare neoplasm whose clinical picture depends on the location of the tumor; however, it must be considered in the differential diagnosis of tumors of the pineal region in the pediatric population.

Adult Atypical Teratoid/Rhabdoid Tumor in the Pineal Region: Case Report and Literature Review

2020 ◽  
Vol 134 ◽  
pp. 428-433 ◽  
Author(s):  
Joana Monteiro ◽  
Bruno Santiago ◽  
Rui Manilha ◽  
Catarina Viegas ◽  
Ana Oliveira ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Pineal Region ◽  
Rhabdoid Tumor ◽  
Atypical Teratoid Rhabdoid Tumor ◽  
Atypical Teratoid

Atypical teratoid/rhabdoid tumor of the pineal region in an adult

2010 ◽  
Vol 113 (2) ◽  
pp. 374-379 ◽  
Author(s):  
Hidehiro Takei ◽  
Adekunle M. Adesina ◽  
Vidya Mehta ◽  
Suzanne Z. Powell ◽  
Lauren A. Langford
Keyword(s):  
Tumor Cells ◽  
Third Ventricle ◽  
Pineal Region ◽  
Rhabdoid Tumor ◽  
Subtotal Resection ◽  
Molecular Testing ◽  
Malignant Rhabdoid Tumor ◽  
Atypical Teratoid Rhabdoid Tumor ◽  
Protein Loss ◽  
Atypical Teratoid

An atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant embryonal tumor most often occurring in the posterior fossa in children younger than 3 years of age. Adult cases of AT/RT are very rare, and 27 cases with a diagnosis of either AT/RT or (malignant) rhabdoid tumor have been reported to date. The authors report an adult case of an AT/RT occurring in the pineal region with molecular cytogenetic and immunohistochemical confirmation. A 33-year-old woman presented with a 2-month history of headache and blurred vision progressing to diplopia, and was admitted emergently due to deteriorating mental status. An MR image showed a heterogeneously enhancing mass involving the posterior third ventricle and pineal region with mild hydrocephalus. She underwent a subtotal resection of the tumor and was then treated with chemoradiation. Thirteen months after surgery, she was still alive with radiological evidence of recurrence/residual lesions. Histological sections showed epithelioid cellular sheets of rhabdoid tumor cells with scattered mitotic figures. Immunohistochemically, the tumor cells were diffusely and strongly positive for epithelial membrane antigen and vimentin, and showed focal expression of glial fibrillary acidic protein, pancytokeratin, and neurofilament protein. Loss of nuclear immunoreactivity for INI1 protein was observed. Fluorescence in situ hybridization analysis showed monosomy 22. Histologically, this tumor consisted exclusively of epithelioid tumor cells with rhabdoid features. The differential diagnoses include rhabdoid glioblastoma, metastatic carcinoma, and rhabdoid meningioma. Molecular testing to identify monosomy 22 or deletions of the chromosome 22q11 containing the INI1/hSNF5 gene and/or immunohistochemical staining with INI1 antibody is of great importance for the diagnosis of this tumor.

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