Pathology of salivary gland dysfunction and restoration of function

2021 ◽  
Author(s):  
Ichiro Saito
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Dysfunction

scholarly journals Disease-Induced Changes in Salivary Gland Function and the Composition of Saliva

2021 ◽  
pp. 002203452110048
Author(s):  
G.B. Proctor ◽  
A.M. Shaalan
Keyword(s):  
Salivary Gland ◽  
Sjögren Syndrome ◽  
Healthy Population ◽  
Sjogren Syndrome ◽  
Salivary Gland Function ◽  
Salivary Gland Dysfunction ◽  
Gland Function ◽  
And Function ◽  
The Impact ◽  
Saliva Composition

Although the physiological control of salivary secretion has been well studied, the impact of disease on salivary gland function and how this changes the composition and function of saliva is less well understood and is considered in this review. Secretion of saliva is dependent upon nerve-mediated stimuli, which activate glandular fluid and protein secretory mechanisms. The volume of saliva secreted by salivary glands depends upon the frequency and intensity of nerve-mediated stimuli, which increase dramatically with food intake and are subject to facilitatory or inhibitory influences within the central nervous system. Longer-term changes in saliva secretion have been found to occur in response to dietary change and aging, and these physiological influences can alter the composition and function of saliva in the mouth. Salivary gland dysfunction is associated with different diseases, including Sjögren syndrome, sialadenitis, and iatrogenic disease, due to radiotherapy and medications and is usually reported as a loss of secretory volume, which can range in severity. Defining salivary gland dysfunction by measuring salivary flow rates can be difficult since these vary widely in the healthy population. However, saliva can be sampled noninvasively and repeatedly, which facilitates longitudinal studies of subjects, providing a clearer picture of altered function. The application of omics technologies has revealed changes in saliva composition in many systemic diseases, offering disease biomarkers, but these compositional changes may not be related to salivary gland dysfunction. In Sjögren syndrome, there appears to be a change in the rheology of saliva due to altered mucin glycosylation. Analysis of glandular saliva in diseases or therapeutic interventions causing salivary gland inflammation frequently shows increased electrolyte concentrations and increased presence of innate immune proteins, most notably lactoferrin. Altering nerve-mediated signaling of salivary gland secretion contributes to medication-induced dysfunction and may also contribute to altered saliva composition in neurodegenerative disease.

The Rheology of Saliva

1987 ◽  
Vol 66 (1_suppl) ◽  
pp. 660-666 ◽  
Author(s):  
W. H. Schwarz
Keyword(s):  
Salivary Gland ◽  
Rheological Properties ◽  
Medical Management ◽  
Artificial Saliva ◽  
Salivary Gland Dysfunction ◽  
Shear Dependent Viscosity ◽  
Saliva Analysis ◽  
Whole Saliva ◽  
Saliva Substitutes ◽  
Dependent Viscosity

The rheology of saliva affects the coating and lubrication of oral surfaces and the consistency of ingested foods. Salivary gland dysfunction can cause tissue damage and dysphagia. Therefore, we have considered the problem of designing a synthetic saliva for medical management. Also, we have measured certain rheological properties [shear-dependent viscosity η (k)] and the frequency-dependent moduli [G′(f) and η′(f)] of normal stimulated whole saliva. Analysis of the rheological data and consideration of requirements for using artificial saliva have resulted in a better understanding of the rheological functions of natural saliva and the desirable characteristics of synthetic saliva. In addition, we have measured rheological properties of two commercial saliva substitutes for comparison.

World Workshop on Oral Medicine VI: a systematic review of medication-induced salivary gland dysfunction: prevalence, diagnosis, and treatment

2015 ◽  
Vol 19 (7) ◽  
pp. 1563-1580 ◽  
Author(s):  
Alessandro Villa ◽  
Andy Wolff ◽  
Doron Aframian ◽  
Arjan Vissink ◽  
Jörgen Ekström ◽  
...  
Keyword(s):  
Systematic Review ◽  
Salivary Gland ◽  
Diagnosis And Treatment ◽  
Oral Medicine ◽  
Salivary Gland Dysfunction

The utility of SPECT in determining the relationship between radiation dose and salivary gland dysfunction after radiotherapy

2001 ◽  
Vol 22 (2) ◽  
pp. 225-231 ◽  
Author(s):  
F. VAN ACKER ◽  
P. FLAMEN ◽  
P. LAMBIN ◽  
ANNELIES MAES ◽  
G. J. KUTCHER ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Radiation Dose ◽  
Salivary Gland Dysfunction ◽  
The Relationship
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