Lipofibroadenoma arising in hyperplastic thymic tissue: Possible perivascular origin of lipofibroadenoma

2021 ◽  
Author(s):  
Yutaka Kurebayashi ◽  
Yuichiro Hayashi ◽  
Katsura Emoto ◽  
Kaoru Kaseda ◽  
Hisao Asamura ◽  
...  
Keyword(s):  
Thymic Tissue

Altered thymic epithelial cells may be decisive for Moloney virus-induced lymphoma development

1983 ◽  
Vol 41 ◽  
pp. 784-785
Author(s):  
U.I. Heine ◽  
G.R.F. Krueger ◽  
E. Munoz ◽  
A. Karpinski
Keyword(s):  
Epithelial Cells ◽  
Leukemia Virus ◽  
Light And Electron Microscopy ◽  
Tumor Development ◽  
Current Evidence ◽  
Thymic Epithelial Cells ◽  
Thymic Tissue ◽  
Newborn Mice ◽  
Moloney Leukemia Virus ◽  
Differentiation Block

Infection of newborn mice with Moloney leukemia virus (M-MuLV) causes a T-cell differentiation block in the thymic cortex accompanied by proliferation and accumulation of prethymic lymphoblasts in the thymus and subsequent spreading of these cells to generate systemic lymphoma. Current evidence shows that thymic reticular epithelial cells (REC) provide a microenvironment necessary for the maturation of prethymic lymphoblasts to mature T-lymphocytes by secretion of various thymic factors. A change in that environment due to infection of REC by virus could be decisive for the failure of lymphoblasts to mature and thus contribute to lymphoma development.We have studied the morphology and distribution of the major thymic cell populations at different stages of tumorigenesis in Balb/c mice infected when newborn with 0.2ml M-MuLV suspension, 6.8 log FFU/ml. Thymic tissue taken at 1-2 weekly intervals up to tumor development was processed for light and electron microscopy, using glutaraldehyde-OsO4fixation and Epon-Araldite embedding.

Elemental content of mast cell granules measured by X-ray microanalysis of rat thymic tissue sections

1986 ◽  
Vol 83 (1) ◽  
pp. 77-87 ◽  
Author(s):  
M.D. Kendall ◽  
A. Warley
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Elemental Content ◽  
Thymic Tissue ◽  
X Ray ◽  
Tissue Sections ◽  
Freeze Dried ◽  
The Mean ◽  
Highly Correlated ◽  
The Individual

Mast cell granules were examined by fully quantitative X-ray microanalysis of 20 cells in freeze-dried cryosections. The mast cells were situated mainly in the connective tissue of the thymic capsule of five adult male Carworth Sprague Europe rats. In addition 30 red blood cells were analysed from the same sections. Nineteen of the mast cells had granules rich in S and K. One cell had smaller granules, and in this cell the granules contained high [Ca] and [P] instead of high [S] and [K]. In the majority of cells (13) the S:K ratio was highly correlated and less than 2.2, whereas in the remaining six cells the individual granule ratios were very variable in any one cell and much higher. The mean granule [K] (994 +/− 57 mmol kg-1 dry wt) was about four times the mean cytoplasmic level of 227 +/− 81 mmol kg-1 dry wt. The existence of this difference in concentration between the granules and the cytoplasm suggests that the K in the granules must be bound. The relationship between the [K] and [S] is discussed with regard to the possible binding of heparin and amines in the granules.

scholarly journals Macrophages prevent human red blood cell reconstitution in immunodeficient mice

Blood ◽  
2011 ◽  
Vol 118 (22) ◽  
pp. 5938-5946 ◽  
Author(s):  
Zheng Hu ◽  
Nico Van Rooijen ◽  
Yong-Guang Yang
Keyword(s):  
Fetal Liver ◽  
In Vivo Model ◽  
Thymic Tissue ◽  
Immunodeficient Mice ◽  
Human Erythropoietin ◽  
Human Cd34 ◽  
Biologic Function ◽  
Human Rbcs

Abstract An animal model supporting human erythropoiesis will be highly valuable for assessing the biologic function of human RBCs under physiologic and disease settings, and for evaluating protocols of in vitro RBC differentiation. Herein, we analyzed human RBC reconstitution in NOD/SCID or NOD/SCID/γc−/− mice that were transplanted with human CD34+ fetal liver cells and fetal thymic tissue. Although a large number of human CD45−CD71+ nucleated immature erythroid cells were detected in the bone marrow, human RBCs were undetectable in the blood of these mice. Human RBCs became detectable in blood after macrophage depletion but disappeared again after withdrawal of treatment. Furthermore, treatment with human erythropoietin and IL-3 significantly increased human RBC reconstitution in macrophage-depleted, but not control, humanized mice. Significantly more rapid rejection of human RBCs than CD47-deficient mouse RBCs indicates that mechanisms other than insufficient CD47-SIRPα signaling are involved in human RBC xenorejection in mice. All considered, our data demonstrate that human RBCs are highly susceptible to rejection by macrophages in immunodeficient mice. Thus, strategies for preventing human RBC rejection by macrophages are required for using immunodeficient mice as an in vivo model to study human erythropoiesis and RBC function.

Cytomorphologic findings of thyroid carcinoma showing thymus-like (CASTLE) differentiation: A case report

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S42-S42
Author(s):  
A K Abu-Salah ◽  
S Segura ◽  
H Mesa ◽  
H M Cramer
Keyword(s):  
Case Report ◽  
Thyroid Carcinoma ◽  
Thymic Carcinoma ◽  
Needle Aspiration ◽  
Central Neck Dissection ◽  
Anaplastic Carcinoma ◽  
Thyroid Neoplasm ◽  
Squamous Differentiation ◽  
Thymic Tissue ◽  
The Right

Abstract Introduction/Objective Thyroid carcinoma showing thymus-like differentiation also known as intrathyroidal thymic carcinoma is a rare thyroid neoplasm arising from either an ectopic intrathyroidal thymic tissue or from remnants of thymobranchial pouches. On fine needle aspiration (FNA) its diagnosis can be challenging due to overlapping morphologic features with other aggressive thyroid carcinomas. Methods/Case Report A 31-year-old female consulted for 6-month history of neck swelling and tenderness. Thyroid ultrasound demonstrated a 2.6 x 2.5 x 2.1 cm nodule in the right lobe with punctate calcifications. FNA showed cellular smears composed of loosely cohesive and single basaloid neoplastic cells exhibiting significant cellular and nuclear pleomorphism. Focal squamous differentiation with keratinization was noted on the cell block sections. Immunocytochemical stains showed that the tumor was positive for cytokeratin AE1/AE3, p40, p63, CD117 and CD5 consistent with intrathyroidal thymic carcinoma. The Ki67 proliferative index was approximately 40%. A right thyroidectomy with central neck dissection confirmed the diagnosis and showed a 3.0 cm tumor with invasion into skeletal muscle, lymphovascular invasion and positive lymph nodes. The patient completed adjuvant radiotherapy and remain in remission at 3-months follow-up. Results (if a Case Study enter NA) NA Conclusion Intrathyroidal thymic carcinoma is a rare thyroid neoplasm that frequently shows squamous differentiation and therefore overlaps with papillary thyroid carcinoma with squamous morulae, squamous cell carcinoma and anaplastic carcinoma. The coexpression of squamous markers together with CD5 and CD117 allows the recognition of CASTLE on FNA samples.

scholarly journals Unraveling the role of ectopic thymic tissue in patients undergoing thymectomy for myasthenia gravis

2019 ◽  
Vol 11 (9) ◽  
pp. 4039-4048 ◽  
Author(s):  
Feng Li ◽  
Ya Tao ◽  
Gero Bauer ◽  
Aron Elsner ◽  
Zhongmin Li ◽  
...  
Keyword(s):  
Myasthenia Gravis ◽  
Thymic Tissue

scholarly journals Distribution of thymic tissue at the anterior mediastinum

1975 ◽  
Vol 70 (4) ◽  
pp. 747-754 ◽  
Author(s):  
Akira Masaoka ◽  
Yutaka Nagaoka ◽  
Yahiro Kotake
Keyword(s):  
Anterior Mediastinum ◽  
Thymic Tissue
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