The relation between anti‐TGBFR1 immunohistochemical reaction and low Ki67, small tumor size and high estrogen receptor expression in invasive breast cancer

2020 ◽  
Vol 70 (6) ◽  
pp. 330-339
Author(s):  
Ritsuko Nakamura ◽  
Takeru Oyama ◽  
Masafumi Inokuchi ◽  
Satoko Ishikawa ◽  
Miki Hirata ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Invasive Breast Cancer ◽  
Tumor Size ◽  
Receptor Expression ◽  
Estrogen Receptor Expression ◽  
Small Tumor ◽  
Immunohistochemical Reaction ◽  
Small Tumor Size

Polo-like kinase: a novel marker of proliferation: Correlation with estrogen-receptor expression in human breast cancer

2000 ◽  
Vol 196 (11) ◽  
pp. 753-759 ◽  
Author(s):  
Georg Wolf ◽  
Ralf Hildenbrand ◽  
Christian Schwar ◽  
Rainer Grobholz ◽  
Manfred Kaufmann ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Human Breast Cancer ◽  
Receptor Expression ◽  
Estrogen Receptor Expression ◽  
Human Breast ◽  
Kinase A

COX-2 expression and clinical outcome in early-stage breast cancer patients treated with adjuvant chemotherapy: A prospective study

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e22165-e22165
Author(s):  
A. Kargi ◽  
M. Ozdogan ◽  
H. Bozcuk ◽  
E. Pestereli ◽  
M. Artac ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Multivariate Analysis ◽  
Adjuvant Chemotherapy ◽  
Menopausal Status ◽  
Receptor Expression ◽  
Estrogen Receptor Expression ◽  
Breast Cancer Patients ◽  
Cox 2 ◽  
A Prospective Study

e22165 Background: To evaluate the association of cox-2 expression with the outcome after adjuvant chemotherapy in patients with early breast cancer. Methods: This was planned as a prospective study recruiting consecutive patients receiving adjuvant anthracycline based chemotherapy and with available tissue blocks permitting all immunohistochemical analyses. Cox-2 expression, in addition to other classical biological factors, was evaluated with immunohistochemistry. Disease and patient related, and biological predictors of both overall survival (OAS) and relapse free survival (RFS) were analyzed by Cox regression analysis. Median and mean survival times were calculated according to the Kaplan Meier method. Results: A total of 88 patients were recruited over a period of 24 months. Median age was 45 (29 to 70), and 60% of subjects were premenapausal. Median tumour diameter and number of axillary lymph nodes involved were 2 cm (1 to 6 cm), and 2 (0 to 15), respectively. Median follow up is 74.2 months. Univariate analysis revealed menopausal status and estrogen receptor expression as predictors of OAS, and menopausal status as the correlate of RFS. Multivariate analysis confirmed the independent predictive value of both menopausal status and estrogen receptor expression for OAS (P=0.009, HR=4.18, and P=0.014, HR=0.20, respectively). No multivariate analysis could be performed for RFS. Cox-2 expression was not associated with OAS or RFS (P=0.208, HR=1.92, and P=0.132, HR=1.89, respectively). Interestingly, Cox-2 expression was correlated with Estrogen receptor (ER) and Progesteron receptor (PR) expression (P=0.006, R=-0.303, and P=0.004, R=-0.312, respectively). Conclusions: Cox-2 expression fails to predict clinical outcome of early breast cancer patients treated with adjuvant chemotherapy. However, Cox-2 expression seems to negatively correlate with ER and PR expression. It should be tested in this patient population whether Cox-2 may play a part in hormonal resistance. No significant financial relationships to disclose.

scholarly journals Estrogen Receptor Expression in Benign Breast Epithelium and Breast Cancer Risk

1998 ◽  
Vol 90 (1) ◽  
pp. 37-42 ◽  
Author(s):  
Seema A. Khan ◽  
Mary A. M. Rogers ◽  
Kamal K. Khurana ◽  
Michael M. Meguid ◽  
Patricia J. Numann
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Receptor Expression ◽  
Estrogen Receptor Expression ◽  
Breast Epithelium

scholarly journals Factors associated with concordant estrogen receptor expression at diagnosis and centralized re-assay in a Danish population-based breast cancer study

2011 ◽  
Vol 51 (2) ◽  
pp. 254-261 ◽  
Author(s):  
Deirdre P. Cronin-Fenton ◽  
Ylva Hellberg ◽  
Kristina L. Lauridsen ◽  
Thomas P. Ahern ◽  
Jens Peter Garne ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Population Based ◽  
Receptor Expression ◽  
Estrogen Receptor Expression ◽  
Danish Population ◽  
Cancer Study ◽  
Factors Associated ◽  
Breast Cancer Study

scholarly journals SGK3 is associated with estrogen receptor expression in breast cancer

2012 ◽  
Vol 134 (2) ◽  
pp. 531-541 ◽  
Author(s):  
Jun Xu ◽  
Ma Wan ◽  
Quanyuan He ◽  
Roland L. Bassett ◽  
Xiaoyong Fu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Receptor Expression ◽  
Estrogen Receptor Expression
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