The importance of melanoma inhibitory activity gene family in the tumor progression of oral cancer

2018 ◽  
Vol 68 (5) ◽  
pp. 278-286 ◽  
Author(s):  
Tomonori Sasahira ◽  
Anja Katrin Bosserhoff ◽  
Tadaaki Kirita
Keyword(s):  
Oral Cancer ◽  
Gene Family ◽  
Tumor Progression ◽  
Inhibitory Activity ◽  
Melanoma Inhibitory Activity

scholarly journals Melanoma Inhibitory Activity and regional lymph node status in malignant melanoma patients

2015 ◽  
Vol 13 (Suppl 1) ◽  
pp. P11
Author(s):  
Angela Sandru ◽  
Silviu Voinea ◽  
Eugenia Panaitescu ◽  
Madalina Bolovan ◽  
Adina Stanciu ◽  
...  
Keyword(s):  
Lymph Node ◽  
Malignant Melanoma ◽  
Inhibitory Activity ◽  
Regional Lymph Node ◽  
Lymph Node Status ◽  
Node Status ◽  
Melanoma Inhibitory Activity ◽  
Melanoma Patients

scholarly journals Storkhead box 2 and melanoma inhibitory activity promote oral squamous cell carcinoma progression

Oncotarget ◽  
2016 ◽  
Vol 7 (18) ◽  
pp. 26751-26764 ◽  
Author(s):  
Tomonori Sasahira ◽  
Yukiko Nishiguchi ◽  
Rina Fujiwara ◽  
Miyako Kurihara ◽  
Tadaaki Kirita ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Inhibitory Activity ◽  
Melanoma Inhibitory Activity

scholarly journals The stress hormone norepinephrine promotes tumor progression through β2-adrenoreceptors in oral cancer

2020 ◽  
Vol 113 ◽  
pp. 104712 ◽  
Author(s):  
Bowen Zhang ◽  
Chenzhou Wu ◽  
Wen Chen ◽  
Ling Qiu ◽  
Shensui Li ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Tumor Progression ◽  
Stress Hormone ◽  
Β2 Adrenoreceptors

scholarly journals Protumoral roles of melanoma inhibitory activity 2 in oral squamous cell carcinoma

2013 ◽  
Vol 108 (7) ◽  
pp. 1460-1469 ◽  
Author(s):  
M Kurihara ◽  
T Kirita ◽  
T Sasahira ◽  
H Ohmori ◽  
S Matsushima ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Inhibitory Activity ◽  
Melanoma Inhibitory Activity

Porphyromonas gingivalis Promotes Oral Squamous Cell Carcinoma Progression in an Immune Microenvironment

2020 ◽  
Vol 99 (6) ◽  
pp. 666-675 ◽  
Author(s):  
L. Wen ◽  
W. Mu ◽  
H. Lu ◽  
X. Wang ◽  
J. Fang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Tumor Progression ◽  
Cell Carcinoma ◽  
Porphyromonas Gingivalis ◽  
Squamous Cell ◽  
Oral Lesions ◽  
Potential Candidate

Increasing evidence has revealed a significant association between microorganisms and oral squamous cell carcinoma (OSCC). Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, is considered an important potential etiologic agent of OSCC, but the underlying immune mechanisms through which P. gingivalis mediates tumor progression of the oral cancer remain poorly understood. Our cohort study showed that the localization of P. gingivalis in tumor tissues was related to poor survival of patients with OSCC. Moreover, P. gingivalis infection increased oral lesion multiplicity and size and promoted tumor progression in a 4-nitroquinoline-1 oxide (4NQO)–induced carcinogenesis mouse model by invading the oral lesions. In addition, CD11b+ myeloid cells and myeloid-derived suppressor cells (MDSCs) showed increased infiltration of oral lesions. Furthermore, in vitro observations showed that MDSCs accumulated when human-derived dysplastic oral keratinocytes (DOKs) were exposed to P. gingivalis, and CXCL2, CCL2, interleukin (IL)–6, and IL-8 may be potential candidate genes that facilitate the recruitment of MDSCs. Taken together, our findings suggest that P. gingivalis promotes tumor progression by generating a cancer-promoting microenvironment, indicating a close relationship among P. gingivalis, tumor progression of the oral cancer, and immune responses.

scholarly journals ADAM17 promotes the invasion of hepatocellular carcinoma via upregulation MMP21

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yuqi Xiang ◽  
Liyu Liu ◽  
Ying Wang ◽  
Bo Li ◽  
Jinwu Peng ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Matrix Metalloproteinase ◽  
Gene Family ◽  
Tumor Progression ◽  
Molecular Mechanism ◽  
Cell Invasion ◽  
Expression Level ◽  
Invasion And Metastasis ◽  
Direct Association ◽  
The Relationship

Abstract Background The upregulation of ADAM17 has been reported to be associated with invasion and metastasis in various tumors, however the molecular mechanism of ADAM17 in the progression of hepatocellular carcinoma (HCC) remain to be clarified. Human matrix metalloproteinase 21 (MMP21), the newest member of the MMP gene family, has been suggested to play an important role in embryogenesis and tumor progression. So far, nothing is known about the relationship between ADAM17 and MMP21. Methods In this study, the expression level of ADAM17 and MMP21 in HCC tissues was measured by immunohistochemistry. The Scratch wounding assay and Transwell were used to identify the invasion and metastasis ability. ELISA was used to evaluate the production of MMP21. Coimmunoprecipitation experiments demonstrated a direct association between ADAM17 and MMP21. HPLC was used to confirmed that ADAM17 participated in the maturation of MMP21. Results Our present data indicated that ADAM17 and MMP21 was significantly upregulated in human HCC tissues. Knockdown of ADAM17 in HCC inhibited cell invasion and metastasis. Moreover, ADAM17 regulates the secretion and expression of MMP21. Furthermore we discovered a direct association between ADAM17 and MMP21, and we also found MMP21 prodomain could be cleaved by ADAM17. Conclusion Our data suggest that ADAM17 plays an important role in the development of HCC invasion and metastasis and this function may be implement by MMP21.

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