The PD-1/PD-L1 axis may be aberrantly activated in occupational cholangiocarcinoma

2017 ◽  
Vol 67 (3) ◽  
pp. 163-170 ◽  
Author(s):  
Yasunori Sato ◽  
Masahiko Kinoshita ◽  
Shigekazu Takemura ◽  
Shogo Tanaka ◽  
Genya Hamano ◽  
...  
Keyword(s):  
Occupational Cholangiocarcinoma

scholarly journals Chemical management and occupational cholangiocarcinoma among workers in printing industry

2016 ◽  
Vol 58 (2) ◽  
pp. 78-83
Author(s):  
Yukie Yanagiba ◽  
Megumi Suda ◽  
Tatushi Toyooka ◽  
Rui-Sheng Wang
Keyword(s):  
Printing Industry ◽  
Chemical Management ◽  
Occupational Cholangiocarcinoma

scholarly journals Changes in Laboratory Test Results and Diagnostic Imaging Presentation before the Detection of Occupational Cholangiocarcinoma

2014 ◽  
Vol 56 (4) ◽  
pp. 317-322 ◽  
Author(s):  
Shoji Kubo ◽  
Shigekazu Takemura ◽  
Chikaharu Sakata ◽  
Yorihisa Urata ◽  
Takayoshi Nishioka ◽  
...  
Keyword(s):  
Diagnostic Imaging ◽  
Laboratory Test ◽  
Test Results ◽  
Laboratory Test Results ◽  
Occupational Cholangiocarcinoma

Multifocal origin of occupational cholangiocarcinoma revealed by comparison of multilesion mutational profiles

2019 ◽  
Vol 41 (3) ◽  
pp. 368-376 ◽  
Author(s):  
Sachiyo Mimaki ◽  
Masahiko Watanabe ◽  
Masahiko Kinoshita ◽  
Riu Yamashita ◽  
Hiroshi Haeno ◽  
...  
Keyword(s):  
Bile Ducts ◽  
Somatic Mutations ◽  
Precancerous Lesions ◽  
Biliary Tree ◽  
Bile Duct Injuries ◽  
Whole Exome ◽  
Mutation Burden ◽  
Invasive Carcinomas ◽  
Occupational Cholangiocarcinoma

Abstract Recently identified occupational cholangiocarcinoma among printing workers is characterized by chronic bile duct injuries and precancerous or early cancerous lesions at multiple sites of the bile ducts. These observations suggested the potential multifocal carcinogenesis of the disease. We performed whole-exome analysis of multiple lesions, including the invasive carcinomas and precancerous lesions of four occupational cholangiocarcinoma cases. A much higher mutation burden was observed in both the invasive carcinomas (mean 76.3/Mb) and precancerous lesions (mean 71.8/Mb) than in non-occupational cholangiocarcinomas (mean 1.6/Mb). Most somatic mutations identified in 11 of 16 lesions did not overlap with each other. In contrast, a unique trinucleotide mutational signature of GpCpY to GpTpY was shared among the lesions. These results suggest that most of these lesions are multiclonal in origin and that common mutagenic processes, which may be induced by exposure to haloalkanes or their metabolites, generated somatic mutations at different sites of the bile ducts. A similarly high mutation rate had already been identified in the precancerous lesions, implying an increased potential for carcinogenesis throughout the biliary tree. These genomic features support the importance of ongoing close follow-up of the patients as a group at high risk of recurrence.

scholarly journals Spontaneous Production of Glutathione-Conjugated Forms of 1,2-Dichloropropane: Comparative Study on Metabolic Activation Processes of Dihaloalkanes Associated with Occupational Cholangiocarcinoma

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Yu Toyoda ◽  
Tappei Takada ◽  
Hiroshi Suzuki
Keyword(s):  
Catalytic Activity ◽  
Positive Relationship ◽  
Metabolic Activation ◽  
Epidemiological Studies ◽  
The Other ◽  
Reactive Metabolites ◽  
Spontaneous Production ◽  
Occupational Cholangiocarcinoma ◽  
Spontaneous Reaction

Recently, epidemiological studies revealed a positive relationship between an outbreak of occupational cholangiocarcinoma and exposure to organic solvents containing 1,2-dichloropropane (1,2-DCP). In 1,2-DCP-administered animal models, we previously found biliary excretion of potentially oncogenic metabolites consisting of glutathione- (GSH-) conjugated forms of 1,2-DCP (GS-DCPs); however, the GS-DCP production pathway remains unknown. To enhance the understanding of 1,2-DCP-related risks to human health, we examined the reactivity of GSH with 1,2-DCP in vitro and compared it to that with dichloromethane (DCM), the other putative substance responsible for occupational cholangiocarcinoma. Our results showed that 1,2-DCP was spontaneously conjugated with GSH, whereas this spontaneous reaction was hardly detected between DCM and GSH. Further analysis revealed that glutathione S-transferase theta 1 (GSTT1) exhibited less effect on the 1,2-DCP reaction as compared with that observed for DCM. Although GSTT1-mediated bioactivation of dihaloalkanes could be a plausible explanation for the production of reactive metabolites related to carcinogenesis based on previous studies, this catalytic pathway might not mainly contribute to 1,2-DCP-related occupational cholangiocarcinoma. Considering the higher catalytic activity of GSTT1 on DCM as compared with that on 1,2-DCP, our findings suggested differences in the activation processes associated with 1,2-DCP and DCM metabolism.

scholarly journals Characteristics of printing company workers newly diagnosed with occupational cholangiocarcinoma

2014 ◽  
Vol 21 (11) ◽  
pp. 809-817 ◽  
Author(s):  
Shoji Kubo ◽  
Masahiko Kinoshita ◽  
Shigekazu Takemura ◽  
Shogo Tanaka ◽  
Hiroji Shinkawa ◽  
...  
Keyword(s):  
Newly Diagnosed ◽  
Occupational Cholangiocarcinoma

scholarly journals Occupational cholangiocarcinoma caused by exposure to 1,2-dichloropropane and/or dichloromethane

2017 ◽  
Vol 2 (2) ◽  
pp. 99-105 ◽  
Author(s):  
Shoji Kubo ◽  
Shigekazu Takemura ◽  
Shogo Tanaka ◽  
Hiroji Shinkawa ◽  
Masahiko Kinoshita ◽  
...  
Keyword(s):  
Occupational Cholangiocarcinoma

scholarly journals Outcomes after resection of occupational cholangiocarcinoma

2016 ◽  
Vol 23 (9) ◽  
pp. 556-564 ◽  
Author(s):  
Shoji Kubo ◽  
Shigekazu Takemura ◽  
Shogo Tanaka ◽  
Hiroji Shinkawa ◽  
Masahiko Kinoshita ◽  
...  
Keyword(s):  
Occupational Cholangiocarcinoma

scholarly journals Screening and surveillance for occupational cholangiocarcinoma in workers exposed to organic solvents

Surgery Today ◽  
2015 ◽  
Vol 46 (6) ◽  
pp. 705-712 ◽  
Author(s):  
Shoji Kubo ◽  
Shigekazu Takemura ◽  
Shogo Tanaka ◽  
Takayoshi Nishioka ◽  
Masahiko Kinoshita ◽  
...  
Keyword(s):  
Organic Solvents ◽  
Screening And Surveillance ◽  
Occupational Cholangiocarcinoma

scholarly journals Hypermutation and unique mutational signatures of occupational cholangiocarcinoma in printing workers exposed to haloalkanes

2016 ◽  
Vol 37 (8) ◽  
pp. 817-826 ◽  
Author(s):  
Sachiyo Mimaki ◽  
Yukari Totsuka ◽  
Yutaka Suzuki ◽  
Chikako Nakai ◽  
Masanori Goto ◽  
...  
Keyword(s):  
Mutational Signatures ◽  
Occupational Cholangiocarcinoma
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