scholarly journals Cytokeratin immunohistochemistry improves interobserver variability between unskilled pathologists in the evaluation of tumor budding in T1 colorectal cancer

2016 ◽  
Vol 66 (2) ◽  
pp. 75-82 ◽  
Author(s):  
Keita Kai ◽  
Shinichi Aishima ◽  
Shigehisa Aoki ◽  
Yukari Takase ◽  
Kazuyoshi Uchihashi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Interobserver Variability ◽  
Tumor Budding ◽  
T1 Colorectal Cancer ◽  
Cytokeratin Immunohistochemistry

Tumor Budding and Pathological Differentiation Are Predictive Markers for Lymph Node Metastasis in T1 Colorectal Cancer

2006 ◽  
Vol 63 (5) ◽  
pp. AB216 ◽  
Author(s):  
Hitoshi Yamauchi ◽  
Kazutomo Togashi ◽  
Hiroshi Kawamura ◽  
Junichi Sasaki ◽  
Masaki Okada ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Predictive Markers ◽  
Tumor Budding ◽  
Node Metastasis ◽  
Pathological Differentiation ◽  
T1 Colorectal Cancer

scholarly journals Immunohistochemical evaluation of tumor budding for stratifying T1 colorectal cancer: optimal cut-off value and a novel computer-assisted semiautomatic method

2018 ◽  
Vol 32 (5) ◽  
pp. 675-683 ◽  
Author(s):  
Manabu Takamatsu ◽  
Hiroshi Kawachi ◽  
Noriko Yamamoto ◽  
Maki Kobayashi ◽  
Yuka Toyama ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Budding ◽  
Computer Assisted ◽  
T1 Colorectal Cancer

scholarly journals Interobserver Variability in the Assessment of Tumor Budding in pT 3/4 Colon Cancer: Improvement by Supporting Immunohistochemistry?

Diagnostics ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 730
Author(s):  
Benedikt Martin ◽  
Patrick Mayr ◽  
Regina Ihringer ◽  
Eva-Maria Schäfer ◽  
Elżbieta Jakubowicz ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Interobserver Variability ◽  
Prognostic Significance ◽  
Distant Metastases ◽  
Consensus Conference ◽  
Tumor Budding ◽  
Cancer Specific Survival ◽  
Cytokeratin Immunohistochemistry ◽  
Different Levels ◽  
Level Of Agreement

The prognostic significance of tumor budding in colon cancer is unequivocally documented, and the recommendations of the International Tumor Budding Consensus Conference (ITBCC) are currently the accepted basis for its assessment. Up to now, it is unknown whether the general use of a supporting cytokeratin immunohistochemistry can improve the interobserver variability and prognostic significance. Six investigators with different levels of experience reassessed 229 cases of colon carcinoma (pT3/4, N+/−, M0) with a supporting cytokeratin immunohistochemistry. The results were compared to previous assessments, which have been performed only on H & E. Bd3 was significantly associated with the occurrence of distant metastases according to the assessments of three out of six investigators (p < 0.05). Only one single investigator reached significant results concerning the cancer specific survival (p = 0.01). The pairwise kappa values range between a poor and moderate level of agreement (range 0.17–0.45; median 0.21). In conclusion, the results show no superiority of the use of an additional cytokeratin immunohistochemistry compared to the conventional analysis on sole H & E slides. Therefore, the general supporting use of a cytokeratin immunohistochemical staining seems to be inadvisable in colon cancer in consideration of necessary resources and costs.

scholarly journals The Relationship Between Tumor Budding, Tumor Microenvironment, and Survival in Patients with Primary Operable Colorectal Cancer

2019 ◽  
Vol 26 (13) ◽  
pp. 4397-4404 ◽  
Author(s):  
Hester C. van Wyk ◽  
Antonia Roseweir ◽  
Peter Alexander ◽  
James H. Park ◽  
Paul G. Horgan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Microenvironment ◽  
Evaluation Method ◽  
Venous Invasion ◽  
Staging System ◽  
Consensus Conference ◽  
Tumor Budding ◽  
Inflammatory Cell Infiltrate ◽  
Cancer Specific Survival ◽  
The Relationship

Abstract Background Tumor budding is an independent prognostic factor in colorectal cancer (CRC) and has recently been well-defined by the International Tumour Budding Consensus Conference (ITBCC). Objective The aim of the present study was to use the ITBCC budding evaluation method to examine the relationship between tumor budding, tumor factors, tumor microenvironment, and survival in patients with primary operable CRC. Methods Hematoxylin and eosin-stained slides of 952 CRC patients diagnosed between 1997 and 2007 were evaluated for tumor budding according to the ITBCC criteria. The tumor microenvironment was evaluated using tumor stroma percentage (TSP) and Klintrup–Makinen (KM) grade to assess the tumor inflammatory cell infiltrate. Results High budding (n = 268, 28%) was significantly associated with TNM stage (p < 0.001), competent mismatch repair (MMR; p < 0.05), venous invasion (p < 0.001), weak KM grade (p < 0.001), high TSP (p < 0.001), and reduced cancer-specific survival (CSS) (hazard ratio 8.68, 95% confidence interval 6.30–11.97; p < 0.001). Tumor budding effectively stratifies CSS stage T1 through to T4 (all p < 0.05) independent of associated factors. Conclusions Tumor budding effectively stratifies patients’ survival in primary operable CRC independent of other phenotypic features. In particular, the combination of T stage and budding should form the basis of a new staging system for primary operable CRC.

ID: 3523886 LONG-TERM OUTCOMES AND SURVIVAL AFTER ENDOSCOPIC OR SURGICAL RESECTION FOR T1 COLORECTAL CANCER: A MULTICENTER RETROSPECTIVE STUDY

2021 ◽  
Vol 93 (6) ◽  
pp. AB86
Author(s):  
Hirohito Tanaka ◽  
Shiko Kuribayashi ◽  
Masanori Sekiguchi ◽  
Atsuo Iwamoto ◽  
Yoko Hachisu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Retrospective Study ◽  
Surgical Resection ◽  
Long Term Outcomes ◽  
T1 Colorectal Cancer

scholarly journals Validation of the International Tumor Budding Consensus Conference 2016 recommendations on tumor budding in stage I-IV colorectal cancer

2019 ◽  
Vol 85 ◽  
pp. 145-151 ◽  
Author(s):  
Heather Dawson ◽  
Francesca Galuppini ◽  
Peter Träger ◽  
Martin D. Berger ◽  
Peter Studer ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Consensus Conference ◽  
Stage I ◽  
Tumor Budding
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