Frequent loss of the expression of multiple subunits of the SWI/SNF complex in large cell carcinoma and pleomorphic carcinoma of the lung

2015 ◽  
Vol 65 (11) ◽  
pp. 595-602 ◽  
Author(s):  
Taichiro Yoshimoto ◽  
Daisuke Matsubara ◽  
Tomoyuki Nakano ◽  
Tomoko Tamura ◽  
Shunsuke Endo ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Large Cell Carcinoma ◽  
Large Cell ◽  
Pleomorphic Carcinoma

Multiregion gene-expression profiling to reveal heterogeneity in molecular subtypes and immunotherapy response signatures in lung cancer.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e20077-e20077
Author(s):  
Won-Chul Lee ◽  
Lixia Diao ◽  
Jing Wang ◽  
Jianhua Zhang ◽  
Emily Roarty ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Carcinoma ◽  
Tumor Heterogeneity ◽  
Molecular Subtype ◽  
Large Cell Carcinoma ◽  
Large Cell ◽  
Pleomorphic Carcinoma ◽  
Tumor Microenvironments ◽  
Molecular Tests ◽  
Gene Expression Signatures

e20077 Background: Intra-tumor heterogeneity (ITH) may be present in all molecular levels. Genomic ITH at the exome level has been reported in many cancer types, but comprehensive gene expression ITH has not been well studied. Methods: We collected 35 samples from 10 NSCLC patients (3 or 4 regions/tumor) including lung adenocarcinoma (n = 6), squamous cell carcinoma (n = 2), large cell carcinoma (n = 1) and pleomorphic carcinoma (n = 1). Using Affymetrix Gene 1.0 ST arrays, we generated the gene expression data for each sample. Diverse gene expression signatures associated with clinical outcomes were tested for ITH. Results: Inter-tumor heterogeneity was generally higher than intra-tumor heterogeneity, but some tumors showed a substantial level of ITH. The analysis of various clinically relevant gene expression signatures including molecular subtype, EMT and immunotherapy response signatures also revealed heterogeneity between different regions of the same tumor. The gene expression ITH we observed was associated with heterogeneous tumor microenvironments represented by stromal and immune cells infiltrated. Conclusions: Our data suggest that RNA-based prognostic or predictive molecular tests should be carefully conducted in consideration of the gene expression ITH.

Large cell carcinoma of lung with osteoclast‐like giant cells

1998 ◽  
Vol 32 (5) ◽  
pp. 482-484 ◽  
Author(s):  
Leung ◽  
Morava‐Protzner
Keyword(s):  
Cell Carcinoma ◽  
Large Cell Carcinoma ◽  
Large Cell ◽  
Giant Cells

Phase II trial of carboplatin in combination with etoposide in locally advanced large cell carcinoma and adenocarcinoma of the lung

Lung Cancer ◽  
1995 ◽  
Vol 12 (3) ◽  
pp. 259-262
Author(s):  
Rafael Fuentes ◽  
Joan Dorca ◽  
Eugeni Canals ◽  
Angel Izquierdo ◽  
Miguel Beltrán ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Phase Ii ◽  
Phase Ii Trial ◽  
Locally Advanced ◽  
Large Cell Carcinoma ◽  
Large Cell ◽  
Adenocarcinoma Of The Lung

Rhabdoid Large Cell Carcinoma of Lung, With Illustrative Immunohistochemical and Molecular Findings

2012 ◽  
Vol 20 (3) ◽  
pp. 208-213 ◽  
Author(s):  
Matthias Dettmer ◽  
Juergen Hench ◽  
Brendan Pang ◽  
Niels Willi ◽  
Gieri Cathomas
Keyword(s):  
Cell Carcinoma ◽  
Large Cell Carcinoma ◽  
Large Cell

scholarly journals Sarcoid Reaction in Primary Tumor of Bronchogenic Large Cell Carcinoma Accompanied with Massive Necrosis.

2001 ◽  
Vol 40 (2) ◽  
pp. 127-130 ◽  
Author(s):  
Kosuke KASHIWABARA ◽  
Masakazu TOYONAGA ◽  
Yuji YAMAGUCHI ◽  
Hiroyuki NAKAMURA ◽  
Seigo HIRAYAMA ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Primary Tumor ◽  
Large Cell Carcinoma ◽  
Large Cell ◽  
Sarcoid Reaction ◽  
Massive Necrosis

scholarly journals Serotype-Specific Killing of Large Cell Carcinoma Cells by Reovirus

Viruses ◽  
2017 ◽  
Vol 9 (6) ◽  
pp. 140 ◽  
Author(s):  
Emily Simon ◽  
Morgan Howells ◽  
Johnasha Stuart ◽  
Karl Boehme
Keyword(s):  
Cell Carcinoma ◽  
Large Cell Carcinoma ◽  
Large Cell ◽  
Carcinoma Cells
Sign in / Sign up

Export Citation Format

Share Document