Recent advances in histogenesis research of lung neuroendocrine cancers: Evidence obtained from functional analyses of primitive neural/neuroendocrine cell-specific transcription factors

2015 ◽  
Vol 65 (6) ◽  
pp. 277-285 ◽  
Author(s):  
Takuya Yazawa
Keyword(s):  
Transcription Factors ◽  
Neuroendocrine Cell ◽  
Recent Advances ◽  
Functional Analyses ◽  
Neuroendocrine Cancers

scholarly journals Genome wide identification and predicted functional analyses of NAC transcription factors in Asian pears

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Mudassar Ahmad ◽  
Xinhui Yan ◽  
Jianzhao Li ◽  
Qinsong Yang ◽  
Wajeeha Jamil ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Nac Transcription Factors ◽  
Genome Wide ◽  
Functional Analyses

scholarly journals Dissecting Transcription Factor-Target Interaction in Bovine Coronavirus Infection

2020 ◽  
Vol 8 (9) ◽  
pp. 1323
Author(s):  
Olanrewaju B. Morenikeji ◽  
Ellis Strutton ◽  
Madeleine Wallace ◽  
Kahleel Bernard ◽  
Elaine Yip ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Phylogenetic Analyses ◽  
Bovine Coronavirus ◽  
Cattle Industry ◽  
Target Interaction ◽  
New Information ◽  
Literature Searches ◽  
Transcription Factor Target ◽  
Functional Analyses ◽  
Significant Disease

Coronaviruses are RNA viruses that cause significant disease within many species, including cattle. Bovine coronavirus (BCoV) infects cattle and wild ruminants, both as a respiratory and enteric pathogen, and possesses a significant economic threat to the cattle industry. Transcription factors are proteins that activate or inhibit transcription through DNA binding and have become new targets for disease therapies. This study utilized in silico tools to identify potential transcription factors that can serve as biomarkers for regulation of BCoV pathogenesis in cattle, both for testing and treatment. A total of 11 genes were identified as significantly expressed during BCoV infection through literature searches and functional analyses. Eleven transcription factors were predicted to target those genes (AREB6, YY1, LMO2, C-Rel, NKX2-5, E47, RORAlpha1, HLF, E4BP4, ARNT, CREB). Function, network, and phylogenetic analyses established the significance of many transcription factors within the immune response. This study establishes new information on the transcription factors and genes related to host-pathogen interactome in BCoV infection, particularly transcription factors YY1, AREB6, LMO2, and NKX2, which appear to have strong potential as diagnostic markers, and YY1 as a potential target for drug therapies.

scholarly journals Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition

2014 ◽  
Vol 42 (1) ◽  
pp. 130-138 ◽  
Author(s):  
Christopher D.O. Cooper ◽  
Joseph A. Newman ◽  
Opher Gileadi
Keyword(s):  
Transcription Factors ◽  
Dna Binding ◽  
Protein Interaction ◽  
Eukaryotic Transcription ◽  
Ets Transcription Factors ◽  
Recent Advances ◽  
Ets Family ◽  
Structural Mechanisms ◽  
Ets Factors ◽  
Binding Mechanisms

The Ets family of eukaryotic transcription factors is based around the conserved Ets DNA-binding domain. Although their DNA-binding selectivity is biochemically and structurally well characterized, structures of homodimeric and ternary complexes point to Ets domains functioning as versatile protein-interaction modules. In the present paper, we review the progress made over the last decade to elucidate the structural mechanisms involved in modulation of DNA binding and protein partner selection during dimerization. We see that Ets domains, although conserved around a core architecture, have evolved to utilize a variety of interaction surfaces and binding mechanisms, reflecting Ets domains as dynamic interfaces for both DNA and protein interaction. Furthermore, we discuss recent advances in drug development for inhibition of Ets factors, and the roles structural biology can play in their future.

scholarly journals Towards understanding of the role of transcription factors in learning processes.

1995 ◽  
Vol 42 (2) ◽  
pp. 221-226 ◽  
Author(s):  
L Kaczmarek
Keyword(s):  
Transcription Factors ◽  
Molecular Biology ◽  
Learning And Memory ◽  
Memory Formation ◽  
Present Knowledge ◽  
Learning Processes ◽  
Recent Advances

Recent advances in application of molecular biology to studies on learning and memory formation suggest that understanding of these seemingly elusive phenomena may be within our reach. This mini-review summarizes the present knowledge on activation and possible functions of transcription factors in learning processes with a focus on studies performed in the author's laboratory.

Going further post-RNA-seq: In silico functional analyses revealing candidate genes and regulatory elements related to mastitis in dairy cattle

2021 ◽  
pp. 1-7
Author(s):  
Hyago Passe Pereira ◽  
Lucas Lima Verardo ◽  
Mayara Morena Del Cambre Amaral Weller ◽  
Ana Paula Sbardella ◽  
Danísio Prado Munari ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Immune Responses ◽  
Streptococcus Agalactiae ◽  
Gene Networks ◽  
Regulatory Elements ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Rna Seq ◽  
Functional Analyses ◽  
The Relationship

Abstract This study aimed to obtain a better understanding of the regulatory genes and molecules involved in the development of mastitis. For this purpose, the transcription factors (TF) and MicroRNAs (miRNA) related to differentially expressed genes previously found in extracorporeal udders infected with Streptococcus agalactiae were investigated. The Gene-TF network highlighted LOC515333, SAA3, CD14, NFKBIA, APOC2 and LOC100335608 and genes that encode the most representative transcription factors STAT3, PPARG, EGR1 and NFKB1 for infected udders. In addition, it was possible to highlight, through the analysis of the gene-miRNA network, genes that could be post-transcriptionally regulated by miRNAs, such as the relationship between the CCL5 gene and the miRNA bta-miR-363. Overall, our data demonstrated genes and regulatory elements (TF and miRNA) that can play an important role in mastitis resistance. The results provide new insights into the first functional pathways and the network of genes that orchestrate the innate immune responses to infection by Streptococcus agalactiae. Our results will increase the general knowledge about the gene networks, transcription factors and miRNAs involved in fighting intramammary infection and maintaining tissue during infection and thus enable a better understanding of the pathophysiology of mastitis.

Expression of developing neural transcription factors in diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH)

2016 ◽  
Vol 469 (3) ◽  
pp. 357-363 ◽  
Author(s):  
Antonio García Escudero ◽  
Enrique Rodríguez Zarco ◽  
Juan Carlos Girón Arjona ◽  
María José Ríos Moreno ◽  
Katherine Gallardo Rodríguez ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Neuroendocrine Cell ◽  
Cell Hyperplasia ◽  
Pulmonary Neuroendocrine Cell
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