Gastric-type endocervical glandular neoplasms associated with aberrant p16 expression and K-RAS gene mutation in Peutz-Jeghers syndrome

2014 ◽  
Vol 64 (6) ◽  
pp. 283-288 ◽  
Author(s):  
Shigemi Ito ◽  
Toru Tase ◽  
Kennichi Satoh ◽  
Miyuki Ueki ◽  
Ikuro Sato ◽  
...  
Keyword(s):  
Gene Mutation ◽  
Ras Gene ◽  
Gastric Type ◽  
Peutz Jeghers Syndrome ◽  
P16 Expression

Gastric-type adenocarcinoma of the cervix in patients with Peutz-Jeghers syndrome: a systematic review of the literature with proposed screening guidelines

2021 ◽  
pp. ijgc-2021-002997
Author(s):  
Sushmita B Gordhandas ◽  
Ryan Kahn ◽  
Dib Sassine ◽  
Emeline M Aviki ◽  
Becky Baltich Nelson ◽  
...  
Keyword(s):  
Systematic Review ◽  
Overall Survival ◽  
Pap Smear ◽  
Early Stage ◽  
Case Reports ◽  
High Risk Population ◽  
Normal Cytology ◽  
Presenting Symptoms ◽  
Gastric Type ◽  
Peutz Jeghers Syndrome

ObjectivesTo perform a systematic review of gastric-type adenocarcinoma of the cervix and lobular endocervical glandular hyperplasia (a possible precursor lesion) in Peutz-Jeghers syndrome, and to analyze data from the literature, along with our institutional experience, to determine recommendations for screening and detection.MethodsA comprehensive literature searc and retrospective search of pathology records at our institutio were conducted. Articles were screened by two independent reviewers. Case reports/series on lobular endocervical glandular hyperplasia/gastric-type adenocarcinoma of the cervix in Peutz-Jeghers syndrome were included. Demographic, clinical, and radiologic information was collected.ResultsA total of 1564 publications were reviewed; 38 met the inclusion criteria. Forty-nine were included in the analysis (43 from the literature, 6 from our institution). Forty-three reported on gastric-type adenocarcinoma alone, 4 on lobular endocervical glandular hyperplasia alone, and 2 on concurrent lobular endocervical glandular hyperplasia/gastric-type adenocarcinoma. Median age at diagnosis was 17 (range, 4–52) for patients with lobular endocervical glandular hyperplasia alone and 35 (range, 15–72) for those with gastric-type adenocarcinoma. The most common presenting symptoms were abdominal/pelvic pain and vaginal bleeding/discharge. Imaging was reported for 27 patients; 24 (89%) had abnormal cervical features. Papanicolaou (Pap) smear prior to diagnosis was reported for 12 patients; 6 (50%) had normal cytology, 4 (33%) atypical glandular cells, and 2 (17%) atypical cells not otherwise specified. Patients with gastric-type adenocarcinoma (n=45) were treated with surgery alone (n=16), surgery/chemotherapy/radiation (n=11), surgery/chemotherapy (n=9), surgery/radiation (n=5), or radiation/chemotherapy (n=4). Twelve (27%) of 45 patients recurred; median progression-free survival was 10 months (range, 1–148). Twenty patients (44%) died; median overall survival was 26 months (range, 2–156). Thirteen patients (27%) were alive with no evidence of disease.ConclusionsGastric-type adenocarcinoma in Peutz-Jeghers syndrome is associated with poor outcomes and short progression-free and overall survival. Screening recommendations, including pathognomonic symptom review and physical examination, with a low threshold for imaging and biopsy, may detect precursor lesions and early-stage gastric-type adenocarcinoma, leading to better outcomes in this high-risk population.PROSPERO registration numberCRD42019118151

scholarly journals Gastric-type mucinous adenocarcinoma of the cervix in a woman with Peutz-Jeghers syndrome

2021 ◽  
Author(s):  
Tong Tong ◽  
Qiong Fan ◽  
Shu Shi ◽  
Yuhong Li ◽  
Yudong Wang
Keyword(s):  
Human Papilloma Virus ◽  
Mucinous Adenocarcinoma ◽  
Clinical Stage ◽  
Young Patients ◽  
Hpv Infection ◽  
Sexual Life ◽  
Autosomal Dominant Disorder ◽  
Papilloma Virus ◽  
Gastric Type ◽  
Peutz Jeghers Syndrome

Abstract Background: Peutz-Jeghers syndrome(PJS) is a very rare autosomal dominant disorder with predisposition to multiple neoplasms. Gastric-type adenocarcinoma (GAS) is a less common carcinoma of the cervix than squamous cell carcinoma, which is more aggressive and has lower 5 year survival rate than usual type endocervical adenocarcinoma (ECA), and unrelated to human papilloma virus(HPV) infection as well. We present a 32 year-old patient with Peutz-Jeghers syndrome who was found to have gastric-type adenocarcinoma of the cervix.Case presentation: A 32-year-old woman without sexual life ever who was diagnosed Peutz-Jeghers syndrome when she was two years old presented with watery discharge for more than 6 months. A tumor around 6cm was found on the cervix and she was diagnosed gastric-type mucinous adenocarcinoma of the cervix clinical stage IB3. She was treated with artery intervention chemotherapy for one course followed by radical surgery and then systematic chemotherapy.Conclusions: The case suggests more thorough cancer screening for patients with PJS as the disorder is rare and has high risk of malignancies. Young patients with Peutz-Jeghers syndrome, including those without sexual life, who have watery discharge or bleeding should be screened for cervical carcinoma even if cytologic results or human papilloma virus (HPV) is negative.

Relationship between cyclooxygenase-2 expression and K-ras gene mutation in colorectal adenomas

2000 ◽  
Vol 15 (11) ◽  
pp. 1277-1281
Author(s):  
Mikio Fujita ◽  
Hirokazu Fukui ◽  
Katsuo Morita ◽  
Shigehiko Fujii ◽  
Yoshihiko Ueda ◽  
...  
Keyword(s):  
Gene Mutation ◽  
Cyclooxygenase 2 ◽  
Colorectal Adenomas ◽  
Ras Gene

K-ras gene mutation as an early prognostic marker of colon cancer

2016 ◽  
Vol 88 (1) ◽  
Author(s):  
Łukasz Szpon ◽  
Aleksander Stal ◽  
Marcin Zawadzki ◽  
Anna Lis-Nawara ◽  
Wojciech Kielan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gene Mutation ◽  
Cancer Incidence ◽  
Early Stage ◽  
Tnm Classification ◽  
Gene Mutations ◽  
Diagnostic Methods ◽  
Female Group ◽  
Ras Gene ◽  
Colorectal Cancer Incidence

AbstractDue to increased colorectal cancer incidence there is a necessity of seeking new both prognostic and prediction factors that will allow to evolve new diagnostic tests. K-ras gene seems to be such a factor and its mutations are considered to be an early marker of progression of colorectal cancer.was to find a correlation between K-ras gene mutation in patients with diagnosed colorectal cancer and selected clinical parameters.A total of 104 patients (41 women and 63 men) with diagnosed colorectal cancer were included in this study. The average age of male group was 68.3 and in female group − 65.9. Samples were taken from paraffine blocks with tissue from diagnosed patients and K-ras gene mutation were identified. Afterwards the statistical analysis was made seeking the correlation between K-ras gene mutation incidence and clinical TNM staging system, tumour localisation, histological type, sex, age.K-ras gene mutations were detected in 20.1% of all colorectal cancers. Significantly higher rate of K-ras gene mutations were diagnosed among patients classified at stage I (40%), stage IIC (50%) and stage IV (50%) according to the TNM classification.The results of our study are compatible with other studies and indicate the correlation between K-ras gene mutation and colorectal cancer incidence. Identification of K-ras gene mutation may complement other diagnostic methods at early stage of colorectal cancer.

Characteristic association between K- ras gene mutation with loss of heterozygosity in X-ray-induced thymic lymphomas of the B6C3F1 mouse

2001 ◽  
Vol 77 (4) ◽  
pp. 465-473 ◽  
Author(s):  
Y. Shimada ◽  
M. Nishimura ◽  
S. Kakinuma ◽  
T. Takeuchi ◽  
T. Ogiu ◽  
...  
Keyword(s):  
Gene Mutation ◽  
Loss Of Heterozygosity ◽  
Ras Gene ◽  
X Ray ◽  
B6c3f1 Mouse

Cyclooxygenase-2 Overexpression Is Related to Polypoid Growth and K-ras Gene Mutation in T1 Colorectal Carcinomas

2004 ◽  
Vol 47 (11) ◽  
pp. 1915-1921 ◽  
Author(s):  
Takuya Okawa ◽  
Keigo Yoshinaga ◽  
Hiroyuki Uetake ◽  
Takanobu Sato ◽  
Tetsuro Higuchi ◽  
...  
Keyword(s):  
Gene Mutation ◽  
Cyclooxygenase 2 ◽  
Colorectal Carcinomas ◽  
Ras Gene ◽  
Polypoid Growth
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