Immune mechanisms of Texel sheep to adult and egg stages of Haemonchus contortus

2021 ◽  
Author(s):  
Andrew R. Weaver ◽  
Javier J. Garza ◽  
Scott P. Greiner ◽  
Scott A. Bowdridge
Keyword(s):  
Haemonchus Contortus ◽  
Immune Mechanisms ◽  
Egg Stages

Gene expression profiles of hair and wool sheep reveal importance of Th2 immune mechanisms for increased resistance to Haemonchus contortus

2015 ◽  
Vol 93 (5) ◽  
pp. 2074-2082 ◽  
Author(s):  
K. M. MacKinnon ◽  
S. A. Bowdridge ◽  
I. Kanevsky-Mullarky ◽  
A. M. Zajac ◽  
D. R. Notter
Keyword(s):  
Gene Expression ◽  
Haemonchus Contortus ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Immune Mechanisms

in vivo anthelmintic activity of Syzygium cumini leaves against Haemonchus contortus in sheep

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
LDR Oliveira ◽  
JPHV Miranda ◽  
GS Curado ◽  
JP Costa Neto ◽  
BF Santos ◽  
...  
Keyword(s):  
Haemonchus Contortus ◽  
Anthelmintic Activity ◽  
Syzygium Cumini

Haemonchus contortus: in vivo anthelmintic activity of leaves of anacardium humile

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
LDR Oliveira ◽  
JPHV Miranda ◽  
GS Curado ◽  
JP Costa Neto ◽  
BF Santos ◽  
...  
Keyword(s):  
Haemonchus Contortus ◽  
Anthelmintic Activity

Effect of Jatropha curcas Latex on L3 Haemonchus contortus Larval Motility

2017 ◽  
Vol 9 (3) ◽  
Author(s):  
Noorzaid Muhamad ◽  
Syahirah Sazeli ◽  
Resni Mona ◽  
Jannathul Firdous
Keyword(s):  
Larvicidal Activity ◽  
Jatropha Curcas ◽  
Haemonchus Contortus ◽  
Anthelmintic Resistance ◽  
Small Ruminants ◽  
Gastrointestinal Nematodes ◽  
Dose Dependent ◽  
Plants Extract

The anthelmintic resistance has limited the control of gastrointestinal nematodes of small ruminants and thus has awakened interest in the study of plants extract as a source of anthelmintics. These experiments were carried out to evaluate the in vitro efficacy of Jatrophacurcas latex extract against Haemonchuscontortus larval motility. To evaluate the larvicidal activity, H.contortus L3 were incubated with the extracts with varying concentration of 5 mg/mL, 10 mg/mL, 15 mg/mL and 20 mg/mL at 27°C for 48, 72 and 96 hrs. The results were subjected to the Kruskal-Wallis test (P less than 0.05). The extracts showed dose-dependent larvicidal effects. These results suggest that J.curcas can be used to control gastrointestinal nematodes of small ruminants.

The Effect of Mineral and Phenothiazine Supplementation on the Resistance of Grazing Lambs to Haemonchus Contortus Infection

1957 ◽  
Vol 16 (4) ◽  
pp. 937-942 ◽  
Author(s):  
R. J. Emerick ◽  
W. J. Bemrick ◽  
A. L. Pope ◽  
W. G. Hoekstra ◽  
P. H. Phillips
Keyword(s):  
Haemonchus Contortus

The Effect of Bleeding versus Previous Infection on the Resistance of Lambs to Subsequent Infections of Haemonchus Contortus

1958 ◽  
Vol 17 (2) ◽  
pp. 363-367 ◽  
Author(s):  
W. J. Bemrick ◽  
R. J. Emerick ◽  
R. F. Shumard ◽  
A. L. Pope ◽  
P. H. Phillips
Keyword(s):  
Haemonchus Contortus ◽  
Previous Infection

Modern pharmacological approaches to primary treatment nephrotic syndrome

2020 ◽  
Vol 24 (4) ◽  
pp. 9-20
Author(s):  
Ya. F. Zverev ◽  
A. Ya. Rykunova
Keyword(s):  
Nephrotic Syndrome ◽  
Monoclonal Antibodies ◽  
Mycophenolate Mofetil ◽  
Beneficial Effect ◽  
Pharmacological Activity ◽  
Glucocorticoid Receptors ◽  
Calcineurin Inhibitors ◽  
Mechanisms Of Action ◽  
Immune Mechanism ◽  
Immune Mechanisms

The review is devoted to the consideration of the most common drugs currently used in the treatment of primary nephrotic syndrome. Mechanisms of pharmacological activity of glucocorticosteroids, ACTH, calcineurin inhibitors cyclosporine A and tacrolimus, alkylating compounds cyclophosphamide and chlorambucil, mycophenolate mofetil, levamisole, abatacept, rituximab and a number of other recently created monoclonal antibodies. An attempt is made to separate the immune and non-immune mechanisms of action of the most common drugs, concerning both the impact on the immunogenetics of the noted diseases and the direct impact on the podocytes that provide permeability of the glomerular filtration barrier and the development of proteinuria. It is shown that the immune mechanisms of corticosteroids are caused by interaction with glucocorticoid receptors of lymphocytes, and nonimmune – with stimulation of the same receptors in podocytes. It was found that the activation of adrenocorticotropic hormone melanocortin receptors contributes to the beneficial effect of the drug in nephrotic syndrome. It is discussed that the immune mechanism of calcineurin inhibitors is provided by the suppression of tissue and humoral immunity, and the non-immune mechanism is largely due to the preservation of the activity of podocyte proteins such as synaptopodin and cofilin. Evidence is presented to show that the beneficial effect of rituximab in glomerulopathies is related to the interaction of the drug with the protein SMPDL-3b in lymphocytes and podocytes. The mechanisms of action of mycophenolate mofetil, inhibiting the activity of the enzyme inosine 5-monophosphate dehydrogenase, which causes the suppression of the synthesis of guanosine nucleotides in both lymphocytes and glomerular mesangium cells, are considered. It is emphasized that the effect of levamisole in nephrotic syndrome is probably associated with the normalization of the ratio of cytokines produced by various T-helpers, as well as with an increase in the expression and activity of glucocorticoid receptors. The mechanisms of pharmacological activity of a number of monoclonal antibodies, as well as galactose, the beneficial effect of which may be provided by binding to the supposed permeability factor produced by lymphocytes, are considered.

Four single nucleotide polymorphisms (SNPs) are associated with resistance and resilience to Haemonchus contortus in Brazilian Morada Nova sheep

2020 ◽  
Vol 279 ◽  
pp. 109053 ◽  
Author(s):  
Marei B. Haehling ◽  
Giovanna G. Cruvinel ◽  
João H.B. Toscano ◽  
Luciana A. Giraldelo ◽  
Isabella B. Santos ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Haemonchus Contortus ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide
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