Signatures of malaria vaccine efficacy in ageing murine immune memory

2014 ◽  
Vol 36 (5) ◽  
pp. 199-206 ◽  
Author(s):  
J. M. Haussig ◽  
J. Burgold ◽  
J. C. R. Hafalla ◽  
K. Matuschewski ◽  
T. W. A. Kooij
Keyword(s):  
Vaccine Efficacy ◽  
Malaria Vaccine ◽  
Immune Memory

scholarly journals Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Carlota Dobaño ◽  
Hèctor Sanz ◽  
Hermann Sorgho ◽  
David Dosoo ◽  
Maximilian Mpina ◽  
...  
Keyword(s):  
Vaccine Efficacy ◽  
Malaria Vaccine

Blood-stage Challenge for Malaria Vaccine Efficacy Trials: A Pilot Study with Discussion of Safety and Potential Value

2008 ◽  
Vol 78 (6) ◽  
pp. 878-883 ◽  
Author(s):  
Frances Sanderson ◽  
Angela Hunt-Cooke ◽  
Philip Bejon ◽  
Laura Andrews ◽  
Alexander D. Douglas ◽  
...  
Keyword(s):  
Pilot Study ◽  
Vaccine Efficacy ◽  
Malaria Vaccine ◽  
Blood Stage ◽  
Potential Value ◽  
Efficacy Trials

scholarly journals Malaria vaccines: lessons from field trials

1994 ◽  
Vol 10 (suppl 2) ◽  
pp. S310-S326 ◽  
Author(s):  
Claudio J. Struchiner ◽  
M. Elizabeth Halloran ◽  
Robert C. Brunet ◽  
José M. C. Ribeiro ◽  
Eduardo Massad
Keyword(s):  
Causal Inference ◽  
Vaccine Efficacy ◽  
Malaria Vaccine ◽  
Field Trials ◽  
Final States ◽  
Vaccine Candidates ◽  
Malaria Vaccines ◽  
Epidemiologic Data

Malaria vaccine candidates have already been tested and new trials are being carried out. We present a brief description of specific issues of validity that are relevant when assessing vaccine efficacy in the field and illustrate how the application of these principles might improve our interpretation of the data being gathered in actual malaria vaccine field trials. Our discussion assumes that vaccine evaluation shares the same general principles of validity with epidemiologic causal inference, i.e., the process of drawing inferences from epidemiologic data aiming at the identification of causes of diseases. Judicious exercise of these principles indicates that, for meaningful interpretation, measures of vaccine efficacy require definitions based upon arguments conditional on the amount of exposure to infection, and specification of the initial and final states in which one believes the effect of interest takes place.

scholarly journals Genetic polymorphism of Plasmodium falciparum circumsporozoite protein (PfCSP) and mismatches against RTS, S/AS01 malaria vaccine observed on Bioko Island, Equatorial Guinea and globally

2020 ◽  
Author(s):  
Hui-Ying Huang ◽  
Xue-Yan Liang ◽  
Li-Yun Lin ◽  
Jiang-Tao Chen ◽  
Carlos Salas Ehapo ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Natural Selection ◽  
Genetic Polymorphism ◽  
Genetic Polymorphisms ◽  
Vaccine Efficacy ◽  
Malaria Vaccine ◽  
Repetitive Sequences ◽  
Circumsporozoite Protein ◽  
Bioko Island ◽  
Selection Of

Abstract Backgroud RTS, S/AS01 is a Plasmodium falciparum circumsporozoite protein ( PfCSP ) based anti-malaria vaccine, but various genetic polymorphisms of PfCSP among global P. falciparum population could lead to mismatch against the PfCSP - based vaccine and reduce vaccine efficacy. This study aimed to investigate the genetic polymorphisms and natural selection of PfCSP in Bioko as well as global P. falciparum population. Methods From January 2011 to December 2018, 148 blood samples were collected from P. falciparum infected Bioko patients and 96 monoclonal sequences of them were successfully acquired and analyzed with 2200 global PfCSP sequences mined from MalariaGEN Pf3k Database and NCBI. Results In Bioko, the N-terminus of PfCSP showed limited genetic variations and the numbers of repetitive sequences (NANP/NVDP) were mainly found as 40 (35%) and 41 (34%) in central region. Most polymorphic characters were found in Th2R/Th3R region, where natural selection (p>0.05) and recombination occurred. The overall pattern of Bioko PfCSP gene had no obvious deviation from African mainland PfCSP (Fst=0.00878, p<0.05). The comparative analysis of Bioko and global PfCSP displayed the various mutation patterns and obvious geographic differentiation among populations from four continents (p<0.05). The global PfCSP C-terminal sequences were clustered into 138 different haplotypes (H_1 to H_138). Only 3.35% of sequences matched 3D7 vaccine strain haplotype (H_1). Conclusions The genetic polymorphism phenomena of PfCSP were found universal. The overall vaccine efficacy might be influenced by the low proportion of vaccine-matched isolates in global parasites population. Genetic polymorphism and geographical characteristics should be considered for future improvement of RTS, S/AS01.

scholarly journals Can growth inhibition assays (GIA) predict blood-stage malaria vaccine efficacy?

2012 ◽  
Vol 8 (6) ◽  
pp. 706-714 ◽  
Author(s):  
Christopher J.A. Duncan ◽  
Adrian V.S. Hill ◽  
Ruth D. Ellis
Keyword(s):  
Growth Inhibition ◽  
Vaccine Efficacy ◽  
Malaria Vaccine ◽  
Blood Stage ◽  
Blood Stage Malaria

scholarly journals Assessing Malaria Vaccine Efficacy

2018 ◽  
Author(s):  
Laurent Rénia ◽  
Yun Shan Goh ◽  
Kaitian Peng ◽  
Marjorie Mauduit ◽  
Georges Snounou
Keyword(s):  
Vaccine Efficacy ◽  
Malaria Vaccine

Malaria vaccine efficacy: overcoming the helminth hurdle

2010 ◽  
Vol 9 (7) ◽  
pp. 707-711 ◽  
Author(s):  
Julio Vladimir Cruz-Chan ◽  
Miguel Rosado-Vallado ◽  
Eric Dumonteil
Keyword(s):  
Vaccine Efficacy ◽  
Malaria Vaccine

scholarly journals A combined analysis of immunogenicity, antibody kinetics and vaccine efficacy from phase 2 trials of the RTS,S malaria vaccine

BMC Medicine ◽  
2014 ◽  
Vol 12 (1) ◽  
Author(s):  
Michael T White ◽  
Philip Bejon ◽  
Ally Olotu ◽  
Jamie T Griffin ◽  
Kalifa Bojang ◽  
...  
Keyword(s):  
Vaccine Efficacy ◽  
Malaria Vaccine ◽  
Phase 2 ◽  
Combined Analysis ◽  
Antibody Kinetics
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