scholarly journals In vitromodelling of rat mucosal mast cell function inTrichinella spiralisinfection

2012 ◽  
Vol 35 (1) ◽  
pp. 21-31 ◽  
Author(s):  
S. M. Thrasher ◽  
L. K. Scalfone ◽  
D. Holowka ◽  
J. A. Appleton
Keyword(s):  
Mast Cell ◽  
Cell Function ◽  
Mucosal Mast Cell

Vidian nerve resection, histamine turnover and mucosal mast cell function in patients with chronic hypertrophic non-allergic rhinitis

1989 ◽  
Vol 28 (3-4) ◽  
pp. 224-230 ◽  
Author(s):  
L. Rucci ◽  
E. Masini ◽  
R. Arbi Riccardi ◽  
E. Giannella ◽  
C. Fioretti ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Mast Cell ◽  
Cell Function ◽  
Mucosal Mast Cell ◽  
Vidian Nerve ◽  
Non Allergic Rhinitis

scholarly journals The Inhibition of Mast Cell Activation of Radix Paeoniae alba Extraction Identified by TCRP Based and Conventional Cell Function Assay Systems

PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0155930 ◽  
Author(s):  
Huiying Fu ◽  
Hongqiang Cheng ◽  
Gang Cao ◽  
Xingde Zhang ◽  
Jue Tu ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Activation ◽  
Cell Function ◽  
Mast Cell Activation ◽  
Conventional Cell ◽  
Radix Paeoniae Alba

Mucosal Mast Cell–Specific Gene Expression Is Promoted by Interdependent Action of Notch and TGF-β Signaling

2021 ◽  
pp. ji2100112
Author(s):  
Nobuhiro Nakano ◽  
Kazuki Saida ◽  
Mutsuko Hara ◽  
Kumi Izawa ◽  
Tomoaki Ando ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mast Cell ◽  
Specific Gene ◽  
Mucosal Mast Cell ◽  
Specific Gene Expression

Mucosal mast cell proliferation following normal and heterotopic infections of the nematodeNippostrongylus brasiliensisin rats

Apmis ◽  
1994 ◽  
Vol 102 (7-12) ◽  
pp. 589-596 ◽  
Author(s):  
NAOKI ARIZONO ◽  
MINORU YAMADA ◽  
TATSUYA TEGOSHI ◽  
MANABU OKADA ◽  
RYUICHI UCHIKAWA ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Mast Cell ◽  
Mucosal Mast Cell

scholarly journals Mast cell function in prostate inflammation, fibrosis, and smooth muscle cell dysfunction

2021 ◽  
Author(s):  
Goutham Pattabiraman ◽  
Ashlee J Bell-Cohn ◽  
Stephen F. Murphy ◽  
Daniel J Mazur ◽  
Anthony J Schaeffer ◽  
...  
Keyword(s):  
Mast Cell ◽  
Smooth Muscle ◽  
Mast Cells ◽  
Cell Activation ◽  
Cell Function ◽  
Critical Role ◽  
Smooth Muscle Contraction ◽  
Urinary Dysfunction ◽  
Mast Cell Activation ◽  
Prostate Inflammation

Intraurethral inoculation of mice with uropathogenic E. coli (CP1) results in prostate inflammation, fibrosis, and urinary dysfunction, recapitulating some but not all of the pathognomonic clinical features associated with benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). In both patients with LUTS and in CP1-infected mice, we observed increased numbers and activation of mast cells and elevated levels of prostate fibrosis. Therapeutic inhibition of mast cells using a combination of mast cell stabilizer (MCS), cromolyn sodium, and the histamine 1 receptor antagonist (H1RA), cetirizine di-hydrochloride, in the mouse model resulted in reduced mast cell activation in the prostate and significant alleviation of urinary dysfunction. Treated mice showed reduced prostate fibrosis, less infiltration of immune cells, and decreased inflammation. In addition, as opposed to symptomatic CP1-infected mice, treated mice showed reduced myosin light chain (MLC)-2 phosphorylation, a marker of prostate smooth muscle contraction. These results show that mast cells play a critical role in the pathophysiology of urinary dysfunction and may be an important therapeutic target for men with BPH/LUTS.

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