Phototherapy‐induced elevation of serum level of melanoma inhibitory activity

2019 ◽  
Author(s):  
Elisabeth Datz ◽  
Florian Zeman ◽  
Michael Koller ◽  
Rolf‐Markus Szeimies ◽  
Mark Berneburg ◽  
...  
Keyword(s):  
Serum Level ◽  
Inhibitory Activity ◽  
Melanoma Inhibitory Activity

scholarly journals Melanoma Inhibitory Activity and regional lymph node status in malignant melanoma patients

2015 ◽  
Vol 13 (Suppl 1) ◽  
pp. P11
Author(s):  
Angela Sandru ◽  
Silviu Voinea ◽  
Eugenia Panaitescu ◽  
Madalina Bolovan ◽  
Adina Stanciu ◽  
...  
Keyword(s):  
Lymph Node ◽  
Malignant Melanoma ◽  
Inhibitory Activity ◽  
Regional Lymph Node ◽  
Lymph Node Status ◽  
Node Status ◽  
Melanoma Inhibitory Activity ◽  
Melanoma Patients

scholarly journals Storkhead box 2 and melanoma inhibitory activity promote oral squamous cell carcinoma progression

Oncotarget ◽  
2016 ◽  
Vol 7 (18) ◽  
pp. 26751-26764 ◽  
Author(s):  
Tomonori Sasahira ◽  
Yukiko Nishiguchi ◽  
Rina Fujiwara ◽  
Miyako Kurihara ◽  
Tadaaki Kirita ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Inhibitory Activity ◽  
Melanoma Inhibitory Activity

scholarly journals Protumoral roles of melanoma inhibitory activity 2 in oral squamous cell carcinoma

2013 ◽  
Vol 108 (7) ◽  
pp. 1460-1469 ◽  
Author(s):  
M Kurihara ◽  
T Kirita ◽  
T Sasahira ◽  
H Ohmori ◽  
S Matsushima ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Inhibitory Activity ◽  
Melanoma Inhibitory Activity

Extended evidence for association between the melanoma inhibitory activity 3 gene and myocardial infarction

2011 ◽  
Vol 105 (04) ◽  
pp. 670-675 ◽  
Author(s):  
Anna Schatke ◽  
Hannah Wolferstetter ◽  
Jakob Mueller ◽  
Albert Schömig ◽  
Adnan Kastrati ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Inhibitory Activity ◽  
Chromosome 1 ◽  
Nucleotide Polymorphisms ◽  
Current Cigarette Smoking ◽  
A Genome ◽  
Increased Risk ◽  
Melanoma Inhibitory Activity ◽  
History Of ◽  
The Impact

SummaryIn a genome-wide scan, isolated single nucleotide polymorphisms (SNPs), including rs17465637, in the melanoma inhibitory activity 3 gene (MIA3) on chromosome 1 were identified to be associated with coronary artery disease and myocardial infarction (MI). Because the role of common variation at the MIA3 locus has not yet been investigated, the aim of this case-control study was to determine the impact of haplotype-tagging SNPs and haplotypes in the MIA3 region on the risk of MI. In a set of nine haplotype-tagging SNPs, rs17465637, but none of the other SNPs, was associated with MI. After adjustments were made for age, gender, history of arterial hypertension, history of hyper-cholesterolaemia, current cigarette smoking and diabetes mellitus, multiple logistic regression analyses showed an increased risk in the carriers of one or two C alleles [adjusted odds ratio (OR) 1.17, 95% confidence interval (CI) 1.04–1.32, and 1.37, 95% CI 1.08–1.74, respectively]. Nine common haplotypes (frequency >1%) were established across the MIA3 region. Two of the haplotypes were associated with an increased risk of MI: the frequent (48%) TGACCAAAG haplotype and the rare (2%) CGACCAAAG haplotype (adjusted OR 1.102, 95% CI 1.002–1.212, and 1.574, 95% CI 1.077–2.298, respectively). Showing association between rs17465637 and MI, this work was consistent with results from the original detection study and most prior replication studies addressing this issue. In addition to correspond with such isolated evidence of association with MI, the present study identified specific haplotypes capturing the risk-related variation in the entire MIA3 region.

scholarly journals Specific Expression and Regulation of the New Melanoma Inhibitory Activity-related GeneMIA2in Hepatocytes

2003 ◽  
Vol 278 (17) ◽  
pp. 15225-15231 ◽  
Author(s):  
Anja K. Bosserhoff ◽  
Markus Moser ◽  
Juergen Schölmerich ◽  
Reinhard Buettner ◽  
Claus Hellerbrand
Keyword(s):  
Inhibitory Activity ◽  
Specific Expression ◽  
Melanoma Inhibitory Activity

scholarly journals Upregulation of HMG1 Leads to Melanoma Inhibitory Activity Expression in Malignant Melanoma Cells and Contributes to Their Malignancy Phenotype

2003 ◽  
Vol 23 (8) ◽  
pp. 2991-2998 ◽  
Author(s):  
Ina Poser ◽  
Michaela Golob ◽  
Reinhard Buettner ◽  
Anja K. Bosserhoff
Keyword(s):  
Transcription Factor ◽  
Malignant Melanoma ◽  
Inhibitory Activity ◽  
Melanoma Cells ◽  
Peptide Sequence ◽  
Transcriptional Level ◽  
Promoter Element ◽  
Promoter Activation ◽  
Mobility Shift ◽  
Melanoma Inhibitory Activity

ABSTRACT Malignant transformation of melanocytes to melanoma cells closely parallels activation of melanoma inhibitory activity (MIA) expression. We have previously shown that upregulation of MIA occurs on a transcriptional level and involves the highly conserved region (HCR) promoter element. We further observed that the HCR element interacts with the melanoma-associated transcription factor (MATF) and thereby confers strong promoter activation. In this study we identify the peptide sequence of MATF and show that it is identical with the transcription factor HMG1. HMG1 was upregulated in malignant melanoma cells and further activated by hypophosphorylation. Stable antisense-HMG1 expression in melanoma cells led to the reduction of MIA promoter activity and protein expression, indicating that HMG1 is a potent regulator of MIA expression. Interestingly, chromatin immunoprecipitation and electrophoretic mobility shift experiments indicated that HMG1 and the NF-κB family member p65 both interact and bind to the HCR promoter element. In summary, our study proves HMG1 and p65 to be important factors in MIA regulation and melanoma progression.

scholarly journals Targeting Melanoma Metastasis and Immunosuppression with a New Mode of Melanoma Inhibitory Activity (MIA) Protein Inhibition

PLoS ONE ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. e37941 ◽  
Author(s):  
Jennifer Schmidt ◽  
Alexander Riechers ◽  
Raphael Stoll ◽  
Thomas Amann ◽  
Florian Fink ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Melanoma Metastasis ◽  
Protein Inhibition ◽  
Melanoma Inhibitory Activity
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