Short-term clinical effects of photodynamic therapy with topical 5-aminolevulinic acid for facial acne conglobata: an open, prospective, parallel-arm trial

2013 ◽  
Vol 29 (5) ◽  
pp. 233-238 ◽  
Author(s):  
Gui-Lan Yang ◽  
Min Zhao ◽  
Jia-Mei Wang ◽  
Chun-Feng He ◽  
Yang Luo ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Aminolevulinic Acid ◽  
Clinical Effects ◽  
Short Term ◽  
Acne Conglobata ◽  
Facial Acne

scholarly journals Topical 5-aminolevulinic acid photodynamic therapy improved refractory acne conglobata and perifolliculitis capitis abscedens et suffodiens rather than hidradenitis suppurativa

2016 ◽  
Vol 09 (01) ◽  
pp. 1640002 ◽  
Author(s):  
Linglin Zhang ◽  
Peiru Wang ◽  
Lei Shi ◽  
Guolong Zhang ◽  
Yunfeng Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Hidradenitis Suppurativa ◽  
Aminolevulinic Acid ◽  
Life Quality ◽  
Poor Response ◽  
Acne Conglobata ◽  
Good Improvement ◽  
Acne Treatment ◽  
Response Formula

Acne conglobata (AC), perifolliculitis capitis abscedens et suffodiens (PCAS) and hidradenitis suppurativa (HS) are uncommon refractory chronic, inflammatory, scarring diseases but cause serious damage to the quality of life. These three diseases are associated with follicular occlusion. Several studies indicated topical 5-aminolevulinic acid photodynamic therapy (ALA-PDT) improved follicular occlusion besides acne treatment. So we attempted to apply ALA-PDT to medicine resistant AC, PCAS and HS. Topical ALA-PDT was applied to 10 patients with AC, seven patients with PCAS and three patients with HS for more than three sessions. All the patients completed the dermatology life quality index (DLQI) questionnaire and were assessed for the efficacy at the baseline and on two weeks after each treatment. Adverse effects were recorded at each visit. The results showed 25.5% (5/20, two cases of AC and three cases of PCAS) of patients achieved excellent improvement after three sessions of PDT and another 60.0% (12/20, eight cases of AC and four cases of PCAS) of patients achieved good improvement. 15.0% (3/20, three cases of HS) got poor response ([Formula: see text] 20% lesions clearance). Another five cases (three cases of AC and two cases of PCAS) also achieved excellent response after 5–7 sessions of PDT. We also found that papular/nodular, cyst/abscess showed higher clearance rate than sinus/fistula (88.5%, 86.1% versus 11.1%). DLQI was reduced after three sessions of PDT in AC and PCAS patients rather than HS patients. 5-ALA-PDT could improve refractory AC and PCAS but could not lead to improvement in late stage of HS. The efficacy increased with more treatment sessions.

scholarly journals Clinical efficacy of 5-aminolevulinic acid photodynamic therapy in the treatment of moderate to severe facial acne vulgaris

2015 ◽  
Vol 10 (3) ◽  
pp. 1194-1198 ◽  
Author(s):  
XIANGQI CHEN ◽  
HONGTAO SONG ◽  
SHENGPING CHEN ◽  
JING ZHANG ◽  
GAOXIANG NIU ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Clinical Efficacy ◽  
Aminolevulinic Acid ◽  
Acne Vulgaris ◽  
Facial Acne

Protoporphyrin IX Fluorescence Photobleaching and the Response of Rat Barrett's Esophagus Following 5-aminolevulinic Acid Photodynamic Therapy

2006 ◽  
Vol 82 (6) ◽  
pp. 1638 ◽  
Author(s):  
Ingrid A. Boere ◽  
Dominic J. Robinson ◽  
Henriette S. de Bruijn ◽  
Jolanda Kluin ◽  
Hugo W. Tilanus ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Aminolevulinic Acid ◽  
Protoporphyrin Ix
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