Clinical Trials and Basic Research in Photodynamic Diagnostics and Therapies from the Center for Laser Diagnostics and Therapy in Poland

2020 ◽  
Vol 96 (3) ◽  
pp. 539-549 ◽  
Author(s):  
Aleksandra Kawczyk‐Krupka ◽  
Dorota Bartusik‐Aebisher ◽  
Wojciech Latos ◽  
Grzegorz Cieślar ◽  
Karolina Sieroń ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Laser Diagnostics ◽  
Basic Research ◽  
Photodynamic Diagnostics ◽  
Diagnostics And Therapy

scholarly journals Osteosarcoma Pathogenesis Leads the Way to New Target Treatments

2021 ◽  
Vol 22 (2) ◽  
pp. 813
Author(s):  
Isabel Fernandes ◽  
Cecília Melo-Alvim ◽  
Raquel Lopes-Brás ◽  
Miguel Esperança-Martins ◽  
Luís Costa
Keyword(s):  
Clinical Trials ◽  
Phase I ◽  
Poor Prognosis ◽  
Therapeutic Targets ◽  
Rare Condition ◽  
Basic Research ◽  
Metastatic Setting ◽  
Phase I And Ii ◽  
The Way

Osteosarcoma (OS) is a rare condition with very poor prognosis in a metastatic setting. Basic research has enabled a better understanding of OS pathogenesis and the discovery of new potential therapeutic targets. Phase I and II clinical trials are already ongoing, with some promising results for these patients. This article reviews OS pathogenesis and new potential therapeutic targets.

scholarly journals Advanced Medical Therapies in the Management of Non-Scarring Alopecia: Areata and Androgenic Alopecia

2020 ◽  
Vol 21 (21) ◽  
pp. 8390
Author(s):  
Antonio Martinez-Lopez ◽  
Trinidad Montero-Vilchez ◽  
Álvaro Sierra-Sánchez ◽  
Alejandro Molina-Leyva ◽  
Salvador Arias-Santiago
Keyword(s):  
Tissue Engineering ◽  
Clinical Trials ◽  
Alopecia Areata ◽  
Human Tissue ◽  
Basic Research ◽  
Androgenic Alopecia ◽  
Medical Products ◽  
Scarring Alopecia ◽  
Medical Therapies ◽  
Surgical Treatments

Alopecia is a challenging condition for both physicians and patients. Several topical, intralesional, oral, and surgical treatments have been developed in recent decades, but some of those therapies only provide partial improvement. Advanced medical therapies are medical products based on genes, cells, and/or tissue engineering products that have properties in regenerating, repairing, or replacing human tissue. In recent years, numerous applications have been described for advanced medical therapies. With this background, those therapies may have a role in the treatment of various types of alopecia such as alopecia areata and androgenic alopecia. The aim of this review is to provide dermatologists an overview of the different advanced medical therapies that have been applied in the treatment of alopecia, by reviewing clinical and basic research studies as well as ongoing clinical trials.

Cysteine protease cathepsins in cardiovascular disease: from basic research to clinical trials

2018 ◽  
Vol 15 (6) ◽  
pp. 351-370 ◽  
Author(s):  
Cong-Lin Liu ◽  
Junli Guo ◽  
Xian Zhang ◽  
Galina K. Sukhova ◽  
Peter Libby ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Clinical Trials ◽  
Cysteine Protease ◽  
Basic Research

scholarly journals Alkali supplementation as a therapeutic in chronic kidney disease: what mediates protection?

2020 ◽  
Vol 319 (6) ◽  
pp. F1090-F1104
Author(s):  
Elinor C. Mannon ◽  
Paul M. O’Connor
Keyword(s):  
Chronic Kidney Disease ◽  
Clinical Trials ◽  
Kidney Disease ◽  
Functional Decline ◽  
Physiological Mechanism ◽  
Basic Research ◽  
Ph Homeostasis ◽  
Disease States ◽  
Kidney Disease Progression ◽  
Acid Base Status

Sodium bicarbonate (NaHCO3) has been recognized as a possible therapy to target chronic kidney disease (CKD) progression. Several small clinical trials have demonstrated that supplementation with NaHCO3 or other alkalizing agents slows renal functional decline in patients with CKD. While the benefits of NaHCO3 treatment have been thought to result from restoring pH homeostasis, a number of studies have now indicated that NaHCO3 or other alkalis may provide benefit regardless of the presence of metabolic acidosis. These data have raised questions as to how NaHCO3 protects the kidneys. To date, the physiological mechanism(s) that mediates the reported protective effect of NaHCO3 in CKD remain unclear. In this review, we first examine the evidence from clinical trials in support of a beneficial effect of NaHCO3 and other alkali in slowing kidney disease progression and their relationship to acid-base status. Then, we discuss the physiological pathways that have been proposed to underlie these renoprotective effects and highlight strengths and weaknesses in the data supporting each pathway. Finally, we discuss how answering key questions regarding the physiological mechanism(s) mediating the beneficial actions of NaHCO3 therapy in CKD is likely to be important in the design of future clinical trials. We conclude that basic research in animal models is likely to be critical in identifying the physiological mechanisms underlying the benefits of NaHCO3 treatment in CKD. Gaining an understanding of these pathways may lead to the improved implementation of NaHCO3 as a therapy in CKD and perhaps other disease states.

scholarly journals Pathophysiologic Features and Prevention of Human and Experimental Acute Tubular Necrosis

2001 ◽  
Vol 12 (suppl 1) ◽  
pp. S20-S32 ◽  
Author(s):  
NORBERT LAMEIRE ◽  
RAYMOND VANHOLDER
Keyword(s):  
Renal Failure ◽  
Clinical Trials ◽  
Acute Renal Failure ◽  
Critical Care ◽  
Basic Research ◽  
Critical Care Units ◽  
Tubular Necrosis ◽  
Negative Results ◽  
Therapeutic Tools ◽  
Injured Kidney

Abstract.Acute renal failure (ARF) remains a common and potentially devastating disorder that affects as many as 5% of all hospitalized patients, with a higher prevalence in patients in critical care units. The focus of this article is on categorizing recent pathophysiologic and clinically relevant developments in the field. The vascular and tubular factors in the pathogenesis of ARF, together with the potential mechanisms of recovery and repair of the injured kidney, are discussed. A number of experimental and clinical interventions to prevent. ARF are summarized. Although the clinical treatment of these patients is still largely supportive and many recent clinical trials showed rather negative results, it is hoped that basic research will provide therapeutic tools to improve the grim prognosis of this disease in the future.

scholarly journals Knowledge of medical students on clinical trials

2019 ◽  
Vol 8 (7) ◽  
pp. 1484
Author(s):  
Ravi Shankar Kanna ◽  
Jagadeesh Alla ◽  
Krishnakanth K.
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Medical Students ◽  
Basic Research ◽  
Thinking Skills ◽  
Cross Sectional Study ◽  
Critical Thinking Skills ◽  
School Students ◽  
Cross Sectional ◽  
Institutional Ethics

Background: Basic research can help medical school students improve critical thinking skills required by medical practice. In this era of evidence-based medicine, the combination of medical education with clinical research is the key to ensure scientific discoveries are translated into clinical practice. This study’s objective was to know the awareness about clinical trials among undergraduate medical students.Methods: After obtaining approval from the Institutional Ethics Committee of NRI Academy of Medical Sciences, Guntur, India, this cross sectional study was conducted in second year medical students after taking their consent. A sample of 90was considered for statistical analysis. A structured questionnaire was used to measure the objective of this study, which had general, regulatory and ethical questions related to clinical trials. Qualitative data variables were expressed by using frequency and Percentage (%).Results: Out of 90 students, it was observed that in the general questions category, 70% of students were aware of the purpose of conducting clinical trials, 50% were aware of the pre-requisites for a participant before participating in a clinical trial and 50% were aware of the parameters evaluated in a clinical trial. 95% of students did not know the response for regulatory questions. The students’ awareness regarding ethics related to clinical trials was better than the other two categories.Conclusions: The overall awareness of clinical trials was low among students though they demonstrated good awareness regarding few aspects of clinical trials.

scholarly journals Publication Landscape on Cushing's Disease: From the Past 40 Years to Future Directions

2021 ◽  
Author(s):  
Ming-Jie Luo ◽  
Kelei Du ◽  
Xiaopeng Guo ◽  
Zihao Wang ◽  
Bing Xing
Keyword(s):  
Clinical Trials ◽  
Cushing’S Disease ◽  
Latent Dirichlet Allocation ◽  
Basic Research ◽  
Research Topic ◽  
Cushing's Disease ◽  
International Studies ◽  
Future Directions ◽  
Country Level ◽  
Research Areas

Abstract PurposeThough literature related to Cushing's disease (CD) has grown significantly, previous reviews exclusively focused on specific research areas and were biased towards highly cited articles. This study aims to systemically analyze the research landscapes and trends using unbiased methods. MethodsWe queried all the CD-related publications in PubMed and clinical trials registered on clinicaltrials.gov. Latent Dirichlet allocation (LDA), a machine learning method, was used to derive research hotspots from article texts. The research topic clusters and country-level collaboration were revealed by network analysis.Results5015 articles were published since 1981, currently growing at 155 per year, with more retrospective studies but fewer prospective studies. Interestingly, the most popular LDA research topics were complications and comorbidities, endocrine hormone tests and surgical therapy, and they formed a remarkable triangle relationship in the research topic network. These topics had numerous international studies and were supported by most funding. In addition, many topics in the basic research domain were proliferating, including mutation, biomarkers, endopeptidases, and other molecular genetics and pathology of CD. Out of 63 registered clinical trials, over 25% were withdrawn due to inadequate patient recruitment or lack of funding.ConclusionsThis publication landscape analysis provided a systemic representation of CD literature regarding the history, current challenges, and future directions, enabling clinicians a rapid and comprehensive insight into the disease.

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