Photoinactivation of Moraxella catarrhalis Using 405‐nm Blue Light: Implications for the Treatment of Otitis Media

2020 ◽  
Vol 96 (3) ◽  
pp. 611-617
Author(s):  
Xiaojing Liu ◽  
Qihang Chang ◽  
Raquel Ferrer‐Espada ◽  
Leon G. Leanse ◽  
Xueping Sharon Goh ◽  
...  
Keyword(s):  
Otitis Media ◽  
Blue Light ◽  
Moraxella Catarrhalis

scholarly journals Moraxella catarrhalis Might Be More Common than Expected in Acute Otitis Media in Young Finnish Children

2016 ◽  
Vol 54 (9) ◽  
pp. 2373-2379 ◽  
Author(s):  
Saara Sillanpää ◽  
Sami Oikarinen ◽  
Markku Sipilä ◽  
Lenka Kramna ◽  
Markus Rautiainen ◽  
...  
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Moraxella Catarrhalis ◽  
Acute Otitis Media ◽  
Pcr Analysis ◽  
Considerable Proportion ◽  
Bacterial Dna ◽  
Content Type ◽  
Conventional Culture

According to studies based on bacterial cultures of middle ear fluids,Streptococcus pneumoniae,Haemophilus influenzae, andMoraxella catarrhalishave been the most common pathogens in acute otitis media. However, bacterial culture can be affected by reduced viability or suboptimal growth of bacteria. PCR detects bacterial DNA from samples with greater sensitivity than culture. In the present study, we analyzed the middle ear pathogens with both conventional culture and semiquantitative real-time PCR in 90 middle ear fluid samples obtained from children aged 5 to 42 months during acute otitis media episodes. Samples were tested for the presence ofS. pneumoniae,H. influenzae,M. catarrhalis,Alloiococcusotitidis,Staphylococcus aureus, andPseudomonas aeruginosa. One or more bacterial pathogens were detected in 42 (47%) samples with culture and in 69 (77%) samples with PCR. According to PCR analysis,M. catarrhalisresults were positive in 42 (47%) samples,H. influenzaein 30 (33%),S. pneumoniaein 27 (30%),A. otitidisin 6 (6.7%),S. aureusin 5 (5.6%), andP. aeruginosain 1 (1.1%). Multibacterial etiology was seen in 34 (38%) samples, andM. catarrhaliswas detected in most (85%) of those cases. Fifteen signals forM. catarrhaliswere strong, suggesting a highly probable etiological role of the pathogen. In conclusion, even thoughM. catarrhalisis often a part of mixed flora in acute otitis media, a considerable proportion of cases may be primarily attributable to this pathogen.

scholarly journals ModM DNA methyltransferase methylome analysis reveals a potential role for Moraxella catarrhalis phasevarions in otitis media

2014 ◽  
Vol 28 (12) ◽  
pp. 5197-5207 ◽  
Author(s):  
Luke V. Blakeway ◽  
Peter M. Power ◽  
Freda E.‐C. Jen ◽  
Sam R. Worboys ◽  
Matthew Boitano ◽  
...  
Keyword(s):  
Otitis Media ◽  
Moraxella Catarrhalis ◽  
Dna Methyltransferase ◽  
Potential Role ◽  
Methylome Analysis

scholarly journals Correlation between Presence of Viable Bacteria and Presence of Endotoxin in Middle-Ear Effusions

1998 ◽  
Vol 36 (11) ◽  
pp. 3417-3419 ◽  
Author(s):  
Jeffrey R. Dingman ◽  
Mark G. Rayner ◽  
Suman Mishra ◽  
Yingze Zhang ◽  
Miles D. Ehrlich ◽  
...  
Keyword(s):  
Haemophilus Influenzae ◽  
Otitis Media ◽  
Middle Ear ◽  
Moraxella Catarrhalis ◽  
Pediatric Patients ◽  
Chronic Otitis Media ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Viable Bacteria

The presence of endotoxin (detected by the Limulusamebocyte lysate assay) was compared to the presence of viableHaemophilus influenzae and Moraxella catarrhalis (detected by PCR) in 106 middle-ear effusions from pediatric patients with chronic otitis media. Endotoxin was found in 81 of the 106 specimens. Of these 81 specimens, 66 (81.5%) also tested positive for one or both of the gram-negative bacteria H. influenzae and M. catarrhalis. The data suggest that viable gram-negative bacteria, detectable by PCR but often undetectable by culture, may be the source of endotoxin in middle-ear effusions.

Five-year prospective study of paediatric acute otitis media in Rochester, NY: modelling analysis of the risk of pneumococcal colonization in the nasopharynx and infection

2013 ◽  
Vol 142 (10) ◽  
pp. 2186-2194 ◽  
Author(s):  
V. FRIEDEL ◽  
S. ZILORA ◽  
D. BOGAARD ◽  
J. R. CASEY ◽  
M. E. PICHICHERO
Keyword(s):  
Risk Factors ◽  
Streptococcus Pneumoniae ◽  
Prospective Study ◽  
Otitis Media ◽  
Moraxella Catarrhalis ◽  
Acute Otitis Media ◽  
Middle Ear Fluid ◽  
Modelling Analysis ◽  
History Of ◽  
Pneumococcal Colonization

SUMMARYDuring a 5-year prospective study of nasopharyngeal (NP) colonization and acute otitis media (AOM) infections in children during the 7-valent pneumococcal conjugate vaccine (PCV) era (July 2006–June 2011) we studied risk factors for NP colonization and AOM. NP samples were collected at ages 6, 9, 12, 15, 18, 24, and 30 months during well-child visits. Additionally, NP and middle ear fluid (MEF) samples were collected at onset of every AOM episode. From 1825 visits (n = 464 children), 5301 NP and 570 MEF samples were collected and analysed for potential otopathogens. Daycare attendance, NP colonization by Moraxella catarrhalis, and siblings aged <5 years increased the risk of Streptococcus pneumoniae NP colonization. NP colonization with S. pneumoniae, M. catarrhalis, or Haemophilus influenzae and a family history of OM increased the risk of AOM. Risk factors that increase the risk of pneumococcal AOM will be important to reassess as we move into a new 13-valent PCV era, especially co-colonization with other potential otopathogens.

Mucosal Immunity and Bacteriology of the Eustachian Tube

1998 ◽  
Vol 77 (9) ◽  
pp. 748-761
Author(s):  
Christian Hjort Sørensen ◽  
Kirsten Brygge
Keyword(s):  
Streptococcus Pneumoniae ◽  
Haemophilus Influenzae ◽  
Otitis Media ◽  
Eustachian Tube ◽  
Mucosal Immunity ◽  
Moraxella Catarrhalis ◽  
Eustachian Tube Dysfunction ◽  
Tube Dysfunction

The pathogenesis of otitis media is a multifaceted process that is not completely understood. Eustachian tube dysfunction plays a central but uncertain role, as do viral and bacterial microorganisms. Of the latter, the three most important are Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis. This article reviews the various mechanisms of infection and the immune system's response to them.

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