scholarly journals Role of Ultrasound and Photoacoustic Imaging in Photodynamic Therapy for Cancer

2020 ◽  
Vol 96 (2) ◽  
pp. 260-279 ◽  
Author(s):  
Scott C. Hester ◽  
Maju Kuriakose ◽  
Christopher D. Nguyen ◽  
Srivalleesha Mallidi
Keyword(s):  
Photodynamic Therapy ◽  
Photoacoustic Imaging

scholarly journals Dual-Agent Photodynamic Therapy with Optical Clearing Eradicates Pigmented Melanoma in Preclinical Tumor Models

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1956 ◽  
Author(s):  
Layla Pires ◽  
Valentin Demidov ◽  
Brian C. Wilson ◽  
Ana Gabriela Salvio ◽  
Lilian Moriyama ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Photoacoustic Imaging ◽  
Critical Role ◽  
Tumor Model ◽  
Optical Clearing ◽  
Treatment Regimes ◽  
Pigmented Lesions ◽  
Melanoma Model

Treatment using light-activated photosensitizers (photodynamic therapy, PDT) has shown limited efficacy in pigmented melanoma, mainly due to the poor penetration of light in this tissue. Here, an optical clearing agent (OCA) was applied topically to a cutaneous melanoma model in mice shortly before PDT to increase the effective treatment depth by reducing the light scattering. This was used together with cellular and vascular-PDT, or a combination of both. The effect on tumor growth was measured by longitudinal ultrasound/photoacoustic imaging in vivo and by immunohistology after sacrifice. In a separate dorsal window chamber tumor model, angiographic optical coherence tomography (OCT) generated 3D tissue microvascular images, enabling direct in vivo assessment of treatment response. The optical clearing had minimal therapeutic effect on the in control, non-pigmented cutaneous melanomas but a statistically significant effect (p < 0.05) in pigmented lesions for both single- and dual-photosensitizer treatment regimes. The latter enabled full-depth eradication of tumor tissue, demonstrated by the absence of S100 and Ki67 immunostaining. These studies are the first to demonstrate complete melanoma response to PDT in an immunocompromised model in vivo, with quantitative assessment of tumor volume and thickness, confirmed by (immuno) histological analyses, and with non-pigmented melanomas used as controls to clarify the critical role of melanin in the PDT response. The results indicate the potential of OCA-enhanced PDT for the treatment of pigmented lesions, including melanoma.

Role of Exosomes in Photodynamic Anticancer Therapy

2020 ◽  
Vol 27 (40) ◽  
pp. 6815-6824 ◽  
Author(s):  
Yuan Jiang ◽  
Chuanshan Xu ◽  
Wingnang Leung ◽  
Mei Lin ◽  
Xiaowen Cai ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Basic Principle ◽  
Photochemical Reaction ◽  
Cell Communication ◽  
Anticancer Therapy ◽  
Bioactive Molecules ◽  
Promising Alternative ◽  
Tumor Tissues ◽  
Significant Attention

Photodynamic Therapy (PDT) is a promising alternative treatment for malignancies based on photochemical reaction induced by Photosensitizers (PS) under light irradiation. Recent studies show that PDT caused the abundant release of exosomes from tumor tissues. It is well-known that exosomes as carriers play an important role in cell-cell communication through transporting many kinds of bioactive molecules (e.g. lipids, proteins, mRNA, miRNA and lncRNA). Therefore, to explore the role of exosomes in photodynamic anticancer therapy has been attracting significant attention. In the present paper, we will briefly introduce the basic principle of PDT and exosomes, and focus on discussing the role of exosomes in photodynamic anticancer therapy, to further enrich and boost the development of PDT.

scholarly journals 066 Role of TGF-β1 in the resistance of squamous cell carcinoma to photodynamic therapy

2021 ◽  
Vol 141 (5) ◽  
pp. S12
Author(s):  
M. Gallego Rentero ◽  
M. Gutiérrez-Pérez ◽  
M. Portillo-Esnaola ◽  
M. Mataix ◽  
L. Najera ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Photodynamic Therapy ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tgf Β1

Combination of photodynamic therapy with doxorubicin in osteosarcoma: Cell death and the role of oxidative stress

2016 ◽  
Vol 61 ◽  
pp. S141
Author(s):  
B. Serambeque ◽  
G. Brites ◽  
M. Laranjo ◽  
G. Chohfi de Miguel ◽  
A. Serra ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Osteosarcoma Cell

The role of photodynamic therapy in the management of stage I/II NSCLC

Lung Cancer ◽  
2001 ◽  
Vol 34 ◽  
pp. 35-38 ◽  
Author(s):  
G. Sutedja ◽  
P.E. Postmus
Keyword(s):  
Photodynamic Therapy ◽  
Stage I

scholarly journals Use of Photodynamic Therapy for Treatment of Actinic Keratoses in Organ Transplant Recipients

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Christina Wlodek ◽  
Faisal R. Ali ◽  
John T. Lear
Keyword(s):  
Photodynamic Therapy ◽  
Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Actinic Keratoses ◽  
Organ Transplant Recipients ◽  
Skin Cancers ◽  
Effective Treatment Modality ◽  
Nonmelanoma Skin Cancers

Solid organ transplant recipients are predisposed to actinic keratoses (AK) and nonmelanoma skin cancers, owing to the lifelong immunosuppression required. Today, increasing numbers of organ transplants are being performed and organ transplant recipients (OTRs) are surviving much longer. Photodynamic therapy (PDT) is proving a highly effective treatment modality for AK amongst this susceptible group of patients. Following an overview of the pathogenesis of AK amongst OTRs, the authors review current safety and efficacy data and how this relates to the role of PDT for the treatment of AK in OTRs.

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