scholarly journals On the Development of a Light Dosimetry Planning Tool for Photodynamic Therapy in Arbitrary Shaped Cavities: Initial Results

2020 ◽  
Vol 96 (2) ◽  
pp. 405-416
Author(s):  
Thérèse E. M. Doeveren ◽  
Rens Bouwmans ◽  
Nienke P. M. Wassenaar ◽  
Willem H. Schreuder ◽  
Maarten J. A. Alphen ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Planning Tool ◽  
Light Dosimetry ◽  
Initial Results

scholarly journals Real-time light dosimetry for intra-cavity photodynamic therapy: Application for pleural mesothelioma treatment

2017 ◽  
Vol 18 ◽  
pp. 155-161 ◽  
Author(s):  
Nacim Betrouni ◽  
Camille Munck ◽  
Wael Bensoltana ◽  
Grégory Baert ◽  
Anne-Sophie Dewalle-Vignion ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Real Time ◽  
Pleural Mesothelioma ◽  
Light Dosimetry

scholarly journals Measurement of Cyanine Dye Photobleaching in Photosensitizer Cyanine Dye Conjugates Could Help in Optimizing Light Dosimetry for Improved Photodynamic Therapy of Cancer

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 1842 ◽  
Author(s):  
Nadine James ◽  
Ravindra Cheruku ◽  
Joseph Missert ◽  
Ulas Sunar ◽  
Ravindra Pandey
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Tumor Response ◽  
Cyanine Dye ◽  
Fluence Rate ◽  
Low Light ◽  
Light Dosimetry ◽  
Light Fluence ◽  
Photodynamic Therapy Of Cancer

Photodynamic therapy (PDT) of cancer is dependent on three primary components: photosensitizer (PS), light and oxygen. Because these components are interdependent and vary during the dynamic process of PDT, assessing PDT efficacy may not be trivial. Therefore, it has become necessary to develop pre-treatment planning, on-line monitoring and dosimetry strategies during PDT, which become more critical for two or more chromophore systems, for example, PS-CD (Photosensitizer-Cyanine dye) conjugates developed in our laboratory for fluorescence-imaging and PDT of cancer. In this study, we observed a significant impact of variable light dosimetry; (i) high light fluence and fluence rate (light dose: 135 J/cm2, fluence rate: 75 mW/cm2) and (ii) low light fluence and fluence rate (128 J/cm2 and 14 mW/cm2 and 128 J/cm2 and 7 mW/cm2) in photobleaching of the individual chromophores of PS-CD conjugates and their long-term tumor response. The fluorescence at the near-infrared (NIR) region of the PS-NIR fluorophore conjugate was assessed intermittently via fluorescence imaging. The loss of fluorescence, photobleaching, caused by singlet oxygen from the PS was mapped continuously during PDT. The tumor responses (BALB/c mice bearing Colon26 tumors) were assessed after PDT by measuring tumor sizes daily. Our results showed distinctive photobleaching kinetics rates between the PS and CD. Interestingly, compared to higher light fluence, the tumors exposed at low light fluence showed reduced photobleaching and enhanced long-term PDT efficacy. The presence of NIR fluorophore in PS-CD conjugates provides an opportunity of fluorescence imaging and monitoring the photobleaching rate of the CD moiety for large and deeply seated tumors and assessing PDT tumor response in real-time.

Calibration of a three-dimensional photodynamic therapy illumination system and its segmentation assessment for port-wine stains

2016 ◽  
Vol 5 (3) ◽  
Author(s):  
Yun Feng ◽  
Xiaoming Hu ◽  
Ya Zhou ◽  
Yong Wang
Keyword(s):  
Photodynamic Therapy ◽  
Three Dimensional ◽  
Calibration Method ◽  
Field Of View ◽  
Utilization Rate ◽  
Color Coding ◽  
Light Dosimetry ◽  
Illumination System ◽  
Low Field ◽  
Fine Distinction

AbstractThe uniformity of light dosimetry is an important parameter that affects the efficacy of photodynamic therapy (PDT). Although this uniformity can be improved by a three-dimensional (3D) digital PDT illumination system, it has a low field-of-view (FOV) utilization rate. A checkerboard calibration method using color coding is proposed to calibrate both the projector and camera of the system with a broad common FOV. Experiments reveal that the proposed method increases the utilization rate by up to three times compared with noncolor-coding methods with almost the same accuracy. A fine distinction of phantom lesions in the 3D system can be obtained by clustering, which may be used to optimize the treatment and light-dosimetry evaluation.

scholarly journals Intra-cavity Photodynamic Therapy for malignant tumors of the paranasal sinuses: An in vivo light dosimetry study

2020 ◽  
Vol 32 ◽  
pp. 101972
Author(s):  
T.E.M. van Doeveren ◽  
R.L.P. van Veen ◽  
F. van den Boom ◽  
I.B. Tan ◽  
W.H. Schreuder ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Paranasal Sinuses ◽  
Malignant Tumors ◽  
Light Dosimetry

The development of radio-opaque, isotropic, fibre-optic probes for light dosimetry studies in photodynamic therapy

1993 ◽  
Vol 38 (10) ◽  
pp. 1529-1536 ◽  
Author(s):  
E J Hudson ◽  
M R Stringer ◽  
H J Van Staveren ◽  
M A Smith
Keyword(s):  
Photodynamic Therapy ◽  
Fibre Optic ◽  
Light Dosimetry
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