Outcomes of granulocyte colony‐stimulating factor use in pediatric kidney transplant recipients: A Pediatric Nephrology Research Consortium study

2021 ◽  
Author(s):  
Rachel M. Engen ◽  
Patricia L. Weng ◽  
Weiwen Shih ◽  
Hiren P. Patel ◽  
Kelsey Richardson ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Pediatric Nephrology ◽  
Granulocyte Colony Stimulating Factor ◽  
Transplant Recipients ◽  
Colony Stimulating Factor ◽  
Kidney Transplant Recipients ◽  
Research Consortium ◽  
Stimulating Factor

THE STATE OF THE CARDIOVASCULAR SYSTEM IN CHILDREN OF KIDNEY TRANSPLANT RECIPIENTS

2021 ◽  
pp. 65-70
Author(s):  
I.A. Kozyro ◽  
◽  
А.V. Sukalo ◽  
О.A. Kondratenko ◽  
Keyword(s):  
Kidney Disease ◽  
Cardiovascular System ◽  
Kidney Transplant ◽  
Clinical Laboratory ◽  
Pediatric Nephrology ◽  
Control Group ◽  
Healthy Children ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Activation Markers

Damage of the cardiovascular system (cardiovascular disease, CVD) is the main cause of reduced life expectancy in children with chronic kidney disease (CKD). In the development of damage of the heart and blood vessels, both traditional factors and caused by impaired renal function, which appear already in the early stages of kidney disease, play a role. Purpose of the study: assessment of markers of the structure, function and metabolism of the heart and study of their changes in children, kidney transplant recipients. Materials and methods. 54 children, a kidney transplant recipients (Tx), who were under observation and treatment at the National Center for Pediatric Nephrology and Renal Replacement Therapy, Minsk 2nd Children's City Clinical Hospital, aged 3 to 17 years, were included in the study. The analysis of the data of the Tx group and conditionally divided subgroups: 1) with glomerular disease leading to the end stage of CKD (ESRD), n = 26; 2) with non-glomerular pathology, n = 27, in one patient the cause of ESRD was not specified. The control group consisted of healthy children from cardiology department without kidney pathology (n = 86). Results. Anamnestic, clinical, laboratory, immunological (serum concentration of T- and B-lymphocyte activation markers (RANTES and BAFF), proinflammatory (caspase 1, IL1fi and TNFa), vascular (VEGF) and tissue (TGF1p) growth factors), metabolic status (adyponectin, leptin, obestatin, vitamin D 25(OH)D), cardiospecific molecules (highly sensitive C-reactive protein (hsCRP), proBNP, transferrin, TSAT index), instrumental changes. Conclusion. Changes in the cardiovascular system in Tx are ambiguous. On the one hand, there is a significant improvement in the geometry of the myocardium and arterial hypertension, on the other hand, the atherogenic direction of metabolic changes and biochemical markers of CVD remains.

Effect of granulocyte colony-stimulating factor on neutropenia in liver transplant recipients with hypersplenism

1994 ◽  
Vol 29 (4) ◽  
pp. 510-513 ◽  
Author(s):  
Shinpachi Ishizone ◽  
Masatoshi Makuuchi ◽  
Seiji Kawasaki ◽  
Hidetoshi Matsunami ◽  
Masaru Terada ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Granulocyte Colony Stimulating Factor ◽  
Transplant Recipients ◽  
Colony Stimulating Factor ◽  
Liver Transplant Recipients ◽  
Stimulating Factor
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