Learning networks in pediatric heart failure and transplantation

2021 ◽  
Author(s):  
Matthew J. O’Connor ◽  
Angela Lorts ◽  
David Kwiatkowski ◽  
Ryan Butts ◽  
Aliessa Barnes ◽  
...  
Keyword(s):  
Heart Failure ◽  
Learning Networks ◽  
Pediatric Heart Failure

scholarly journals Central Nervous System Changes in Pediatric Heart Failure: A Volumetric Study

2010 ◽  
Vol 31 (7) ◽  
pp. 969-976 ◽  
Author(s):  
Jondavid Menteer ◽  
Paul M. Macey ◽  
Mary A. Woo ◽  
Ashok Panigrahy ◽  
Ronald M. Harper
Keyword(s):  
Heart Failure ◽  
Central Nervous System ◽  
Nervous System ◽  
System Changes ◽  
Volumetric Study ◽  
Pediatric Heart Failure

scholarly journals Pediatric Heart Failure: A Practical Guide to Diagnosis and Management

2017 ◽  
Vol 58 (4) ◽  
pp. 303-312 ◽  
Author(s):  
Daniele Masarone ◽  
Fabio Valente ◽  
Marta Rubino ◽  
Rossella Vastarella ◽  
Rita Gravino ◽  
...  
Keyword(s):  
Heart Failure ◽  
Diagnosis And Management ◽  
Practical Guide ◽  
Pediatric Heart Failure

Nesiritide in the management of treatment refractory pediatric heart failure

2006 ◽  
Vol 17 (3) ◽  
pp. 101-107 ◽  
Author(s):  
Michael O'Byrne ◽  
Kristin Ognibene ◽  
Marilyn Morris
Keyword(s):  
Heart Failure ◽  
Pediatric Heart Failure ◽  
Treatment Refractory

In Vivo Evaluation of Bioprinted Cardiac Patches Composed of Cardiac-Specific Extracellular Matrix and Progenitor Cells in a Model of Pediatric Heart Failure

2021 ◽  
Author(s):  
Donald Bejleri ◽  
Matthew Robeson ◽  
Milton Brown ◽  
Jervaughn Hunter ◽  
Joshua Maxwell ◽  
...  
Keyword(s):  
Heart Failure ◽  
Extracellular Matrix ◽  
Congenital Heart ◽  
Pediatric Patients ◽  
Heart Defects ◽  
In Vivo Evaluation ◽  
Surgical Methods ◽  
Pediatric Heart Failure ◽  
The Right

Pediatric patients with congenital heart defects (CHD) often present with heart failure from increased load on the right ventricle (RV) due to both surgical methods to treat CHD and the...

Abstract 416: Pluripotent Stem Cell Signaling in Pediatric Heart Failure Patients

2016 ◽  
Vol 119 (suppl_1) ◽  
Author(s):  
Kathleen C Woulfe ◽  
Phillip Tatman ◽  
Anis Karimpour-Fard ◽  
Xuan Jiang ◽  
Karin Nunley ◽  
...  
Keyword(s):  
Heart Failure ◽  
Stem Cell ◽  
Cell Signaling ◽  
Dilated Cardiomyopathy ◽  
Pediatric Patients ◽  
Disease Process ◽  
Idiopathic Dilated Cardiomyopathy ◽  
Cytokine Signaling ◽  
Common Indication ◽  
Pediatric Heart Failure

Pediatric heart failure is a heterogeneous disease process with congenital heart disease being the most common indication for heart transplantation in infants, and dilated cardiomyopathy (DCM) the most common indication in older children. Due to limitations of studying pediatric populations, there is no specific therapy for children with DCM. Importantly, the application of proven adult therapies to pediatric patients with DCM has resulted in no substantial improvement in survival over the past three decades. Therefore, there is a clear need for new approaches to better understand this disease process. In this study, we investigated global cardiac transcriptome and circulating serum proteome changes in pediatric patients with idiopathic dilated cardiomyopathy (IDC) and non-failing controls. Changes were identified in cytokine signaling, signal transduction, and transcription in pediatric IDC patients when compared to non-failing controls. Interestingly, these changes closely resemble the induction of stem cell pluripotency and signaling in resting stem cell populations. Importantly, the transcriptome changes are age-specific and were not observed in adult IDC patients. In addition, the protein profile in serum from pediatric IDC patients identified several factors related to inflammation, and treatment of cardiomyocyte-derived induced pluripotent stem cells (iPSC) with pediatric IDC serum recapitulated pathologic changes in gene expression, including expression of genes altered in the failing pediatric heart. These findings suggest that pathologic changes in cardiomyocytes may be triggered by circulating factors present in the serum resulting in pluripotent and stem cell signaling. These results provide several novel targets for future research and therapeutic intervention.

Electronic Mental Health Screening in a Pediatric Heart Failure and Transplant Clinic

2020 ◽  
Vol 39 (4) ◽  
pp. S130
Author(s):  
R. Butts ◽  
C. Anton ◽  
N. BaezHernandez ◽  
M. Bano ◽  
D. Sutcliffe ◽  
...  
Keyword(s):  
Mental Health ◽  
Heart Failure ◽  
Health Screening ◽  
Mental Health Screening ◽  
Pediatric Heart Failure

scholarly journals Pediatric heart failure therapy: why β1-receptor blocker, tissue ACE-I and mineralocorticoid-receptor-blocker?

2019 ◽  
Vol 8 (2) ◽  
pp. 127-127
Author(s):  
Sabine Recla ◽  
Dorle Schmidt ◽  
Thushiha Logeswaran ◽  
Anoosh Esmaeili ◽  
Dietmar Schranz
Keyword(s):  
Heart Failure ◽  
Mineralocorticoid Receptor ◽  
Receptor Blocker ◽  
Heart Failure Therapy ◽  
Pediatric Heart Failure
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