scholarly journals Review of the impact of donor characteristics on pediatric heart transplant outcomes

2020 ◽  
Vol 24 (3) ◽  
pp. e13680
Author(s):  
Jennifer Conway ◽  
Jean A. Ballweg ◽  
Matthew Fenton ◽  
Steve Kindel ◽  
Maryanne Chrisant ◽  
...  
Keyword(s):  
Heart Transplant ◽  
Transplant Outcomes ◽  
Donor Characteristics ◽  
The Impact ◽  
Pediatric Heart Transplant

scholarly journals The impact of cognitive delay on pediatric heart transplant outcomes

2017 ◽  
Vol 21 (2) ◽  
pp. e12896 ◽  
Author(s):  
Christopher Prendergast ◽  
Meghann McKane ◽  
Debra A. Dodd ◽  
Justin Godown
Keyword(s):  
Heart Transplant ◽  
Transplant Outcomes ◽  
Cognitive Delay ◽  
The Impact ◽  
Pediatric Heart Transplant

Geographic Distance From Transplant Center Does Not Impact Pediatric Heart Transplant Outcomes

2018 ◽  
Vol 28 (2) ◽  
pp. 170-173
Author(s):  
Meghann McKane ◽  
Debra A. Dodd ◽  
Bret A. Mettler ◽  
Kari A. Wujcik ◽  
Justin Godown
Keyword(s):  
Heart Transplantation ◽  
Heart Transplant ◽  
Blood Type ◽  
Transplant Recipients ◽  
Transplant Outcomes ◽  
Transplant Center ◽  
Significant Difference ◽  
Heart Transplant Recipients ◽  
The Impact ◽  
Pediatric Heart Transplant

Background: Many pediatric heart transplant recipients live a significant distance from their transplant center. This results in families either traveling long distances or relying on outside physicians to assume aspects of their care. Distance has been implicated to play a role in congenital heart disease outcomes, but its impact on heart transplantation has not been reported. The aim of this study was to assess the impact of distance on pediatric heart transplant outcomes. Methods: The Scientific Registry of Transplant Recipients database was queried for all pediatric heart transplant recipients from large US children’s hospitals (1987-2014). Patients were stratified into 4 groups (<20, 20-50, 50-100, and >100 miles) based on distance. Survival curves were generated and compared using the log-rank test. Cox proportional hazards regression was performed to adjust for differences between groups. Results: A total of 4768 patients were included in the analysis, of which 1435 (30.1%) were <20 miles, 940 (19.7%) were 20 to 50 miles, 806 (16.9%) were 50 to 100 miles, and 1587 (33.3%) were >100 miles from their transplant center. There was no difference in posttransplant survival based on distance after adjusting for patient age, gender, ethnicity, blood type, diagnosis, listing status, and the need for pretransplant ventricular assist device, extracorporeal membrane oxygenation, or ventilator support. Conclusion: There is no significant difference in graft survival after pediatric heart transplantation based on patient distance from their transplant center. Our data suggest the current strategy of transitioning some aspects of transplant care to local physicians or management from a distance does not increase posttransplant mortality risk.

The Impact of Tracheostomy on Pediatric Heart Transplant Outcomes: A Multi-Institutional Analysis

2017 ◽  
Vol 36 (4) ◽  
pp. S23-S24
Author(s):  
J.A. Spinner ◽  
S.W. Denfield ◽  
K. Puri ◽  
S.A. Morris ◽  
B.S. Moffett ◽  
...  
Keyword(s):  
Heart Transplant ◽  
Institutional Analysis ◽  
Transplant Outcomes ◽  
The Impact ◽  
Pediatric Heart Transplant

Impact of tacrolimus variability on pediatric heart transplant outcomes

2021 ◽  
Author(s):  
Megan Sirota ◽  
Caroline Heyrend ◽  
Zhining Ou ◽  
Susan Masotti ◽  
Eric Griffiths ◽  
...  
Keyword(s):  
Heart Transplant ◽  
Transplant Outcomes ◽  
Pediatric Heart Transplant

Abstract 12932: The ABO Blood Group of Donor Hearts Determine the Impact of Cold Preservation Duration on Heart Transplant Outcomes

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Paul C TANG ◽  
Jonathan W Haft ◽  
IENGLAM LEI ◽  
Zhong Wang ◽  
Eugene Chen ◽  
...  
Keyword(s):  
Heart Transplant ◽  
Allograft Rejection ◽  
Blood Type ◽  
Graft Dysfunction ◽  
Ischemic Time ◽  
Cold Preservation ◽  
Transplant Outcomes ◽  
Chronic Allograft Rejection ◽  
Propensity Matching ◽  
The Impact

Background: Tolerance of donor hearts of different ABO blood types to allograft ischemic time has not been previously examined. Objectives: We determined the impact of allograft ischemic time on heart transplant outcomes with differing ABO donor organ types. Methods: We identified 32,454 heart transplants (2000-2016) from the United Network for Organ Sharing database. Continuous variables were analyzed with t-test and categorical variables were compared with Chi-squared test. Survival was determined using log-rank or Cox regression tests. Propensity matching adjusted for preoperative variables. Results: Comparing allograft ischemic times <4 hours (hr, n=6579) versus ≥4hr (n=25,875), the odds ratio (OR) for death at 15 years following prolonged allograft ischemic time (≥4hrs) for blood type O, A, B, and AB were 1.106 (P<0.001), 1.062 (P<0.001), 1.059 (P=0.062), 1.114 (P=0.221), respectively. Unadjusted data demonstrated higher mortality for transplantation of O versus non-O donor hearts for allograft ischemic times ≥4 hours (OR=1.164, P<0.001). Following propensity matching, O donor hearts continued to have worse survival if preserved for ≥4hrs (OR=1.137, P=0.008), but not if allograft ischemic time was <4hrs (OR=1.042, P=0.113). In a matched group with ≥4hrs of allograft ischemic time, patients receiving O donor organs were more likely to experience death from primary allograft dysfunction (2.5% vs 1.7%, P=0.052) and chronic allograft rejection (1.9% versus 1.1%, P=0.021). No difference in death from primary allograft graft dysfunction or chronic allograft rejection was seen with <4hr of allograft ischemic time (P>0.150). Conclusions: Compared with non-O hearts, transplantation with O donor hearts stored for ≥4hrs leads to worse survival, with higher rates of primary graft dysfunction and chronic rejection. Caution should be practiced when considering donor hearts with the O blood type when extended cold preservation times are anticipated.

349 The Impact of Preservative Solution on Heart Transplant Outcomes

2011 ◽  
Vol 30 (4) ◽  
pp. S121
Author(s):  
T.J. George ◽  
G.J. Arnaoutakis ◽  
W.A. Baumgartner ◽  
A.S. Shah ◽  
J.V. Conte
Keyword(s):  
Heart Transplant ◽  
Transplant Outcomes ◽  
Preservative Solution ◽  
The Impact

The Impact of Race on Hemodynamics and Heart Transplant Outcomes

2017 ◽  
Vol 36 (4) ◽  
pp. S231
Author(s):  
B.A. Smith ◽  
N. Bassi ◽  
C. Wright ◽  
S. Kalantari-Tannenbaum ◽  
J. Grinstein ◽  
...  
Keyword(s):  
Heart Transplant ◽  
Transplant Outcomes ◽  
The Impact
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