Protective immunity and use of bortezomib for antibody-mediated rejection in a pediatric kidney transplant recipient

2014 ◽  
Vol 18 (4) ◽  
pp. E100-E105 ◽  
Author(s):  
Donna J. Claes ◽  
Hong Yin ◽  
Jens Goebel
Keyword(s):  
Transplant Recipient ◽  
Kidney Transplant ◽  
Protective Immunity ◽  
Kidney Transplant Recipient ◽  
Antibody Mediated Rejection

scholarly journals Antibody-mediated rejection due to anti-HLA-DQ antibody after pregnancy and delivery in a female kidney transplant recipient

Nephrology ◽  
2018 ◽  
Vol 23 ◽  
pp. 81-84
Author(s):  
Makoto Sagasaki ◽  
Yasuyuki Nakada ◽  
Izumi Yamamoto ◽  
Mayuko Kawabe ◽  
Takafumi Yamakawa ◽  
...  
Keyword(s):  
Transplant Recipient ◽  
Kidney Transplant ◽  
Kidney Transplant Recipient ◽  
Antibody Mediated Rejection ◽  
Hla Dq ◽  
Pregnancy And Delivery

Antibody‐mediated rejection with the presence of glomerular crescents in a pediatric kidney transplant recipient: A case report

2020 ◽  
Vol 24 (5) ◽  
Author(s):  
Vasiliki Karava ◽  
Hara Gakiopoulou ◽  
Argyroula Zampetoglou ◽  
Smaragdi Marinaki ◽  
Sofia Havaki ◽  
...  
Keyword(s):  
Case Report ◽  
Transplant Recipient ◽  
Kidney Transplant ◽  
Kidney Transplant Recipient ◽  
Antibody Mediated Rejection

Eculizumab to Treat Antibody-Mediated Rejection in a 7-Year-Old Kidney Transplant Recipient

PEDIATRICS ◽  
2015 ◽  
Vol 135 (2) ◽  
pp. e551-e555 ◽  
Author(s):  
H. Chehade ◽  
S. Rotman ◽  
M. Matter ◽  
E. Girardin ◽  
V. Aubert ◽  
...  
Keyword(s):  
Transplant Recipient ◽  
Kidney Transplant ◽  
Kidney Transplant Recipient ◽  
Antibody Mediated Rejection

scholarly journals Chronic Active Antibody-Mediated Rejection with Linear IgG Deposition on Glomerular Capillaries in a Kidney Transplant Recipient

Nephron ◽  
2020 ◽  
pp. 1-5
Author(s):  
Kenichiro Miura ◽  
Yoko Shirai ◽  
Naoto Kaneko ◽  
Tomoo Yabuuchi ◽  
Kiyonobu Ishizuka ◽  
...  
Keyword(s):  
Transplant Recipient ◽  
Kidney Transplant ◽  
Cell Injury ◽  
Kidney Transplant Recipient ◽  
Hla Antigens ◽  
Human Leukocyte ◽  
Renal Hypoplasia ◽  
Hla Antibodies ◽  
Antibody Mediated Rejection ◽  
Glomerular Capillaries

Glomerular IgG deposition is rarely observed in antibody-mediated rejection. Here, we report chronic active antibody-mediated rejection with linear IgG deposition on glomerular capillary walls in a pediatric kidney transplant recipient. A 6-year-old boy with bilateral renal hypoplasia underwent preemptive deceased-donor kidney transplantation. Five years after the transplantation, an allograft biopsy revealed chronic active antibody-mediated rejection with diffuse linear IgG deposition on glomerular capillaries. Anti-glomerular basement membrane antibody, donor-specific anti-human leukocyte antigen (HLA) antibodies, and anti-angiotensin II type 1 receptor antibody were negative. A multiplex antibody assay identified anti-major histocompatibility complex class I chain-related molecule A antibody. Additionally, a single-antigen bead assay identified autoantibodies to 12 non-HLA antigens, including vimentin and glutathione S-transferase theta-1. To investigate whether IgG autoantibodies in the patient’s serum bind to antigens on glomerular capillaries, we incubated the patient’s serum with 0-h biopsy specimens of tissue donated to the patient and a control subject, both obtained immediately after nephrectomy from respective donors. IgG signals were observed in neither patient nor control samples. Nevertheless, linear IgG deposition may be explained by the binding of autoantibodies to non-HLA antigens that are usually hidden and only exposed via severe endothelial cell injury. Further studies are needed to confirm the significance of non-HLA antibodies in glomerular IgG deposition.

scholarly journals Primary Hyperaldosteronism: A Rare Cause of Malignant Hypertension with Thrombotic Microangiopathy in a Kidney Transplant Recipient

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Carolina Ormonde ◽  
Sara Querido ◽  
Nuno Rombo ◽  
Rita Roque ◽  
Belarmino Clemente ◽  
...  
Keyword(s):  
Transplant Recipient ◽  
Kidney Transplant ◽  
Thrombotic Microangiopathy ◽  
Viral Infections ◽  
Kidney Transplant Recipient ◽  
Calcineurin Inhibitors ◽  
Organ Damage ◽  
Primary Hyperaldosteronism ◽  
Malignant Hypertension ◽  
Antibody Mediated Rejection

Thrombotic microangiopathy (TMA) is a rare disease that presents with haemolysis and organ damage. The kidney is one of the main affected organs, and TMA is associated with serious complications and increased mortality. In transplanted patients, TMA is even less common and has a variety of possible causes, including thrombotic thrombocytopenic purpura (TTP) and haemolytic-uremic syndrome (HUS), infections, drugs, autoimmune disease, tumours, and malignant hypertension. Transplant-related causes, such as antibody-mediated rejection, calcineurin inhibitors, and viral infections, need to be considered as well. The authors report a rare case of TMA in a kidney transplant recipient, whose investigation revealed malignant hypertension secondary to primary hyperaldosteronism.

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