Mortality after pediatric kidney transplantation in England - a population-based cohort study

2013 ◽  
Vol 18 (1) ◽  
pp. 16-22 ◽  
Author(s):  
Daniela Farrugia ◽  
James Cheshire ◽  
Sophia Mahboob ◽  
Irena Begaj ◽  
Sajan Khosla ◽  
...  
Keyword(s):  
Cohort Study ◽  
Kidney Transplantation ◽  
Population Based ◽  
Pediatric Kidney Transplantation

scholarly journals Correlation between kidney transplantation and colorectal cancer in hemodialysis patients: A nationwide, retrospective, population-based cohort study

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Han-En Wang ◽  
Yu-Chan Liao ◽  
Je-Ming Hu ◽  
Wen-Chih Wu ◽  
Wan-Yun Chou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cohort Study ◽  
Kidney Transplantation ◽  
Cumulative Incidence ◽  
Population Based ◽  
Hemodialysis Patients ◽  
Rank Test ◽  
Research Database ◽  
Kaplan Meier ◽  
Increased Risk

Abstract Background Kidney transplantation (KT) correlates with an increased risk of developing several malignancies; however, the risk of colorectal cancer (CRC) after KT remains debatable and has been marginally explored. Hence, in this nationwide, retrospective, population-based cohort study, we aimed to examine the correlation between KT and CRC in a large-scale population-based Chinese cohort. Methods We identified a total of 3739 regular hemodialysis patients undergoing KT (exposed cohort) and 42,324 hemodialysis patients not undergoing KT (non-exposed cohort) between 2000 and 2008 from Taiwan’s National Health Insurance Research Database (NHIRD). Both cohorts were followed up from January 1, 2000, to the date of CRC diagnosis, death, or the end of 2013. Using Kaplan–Meier method, we measured the cumulative incidence of CRC in each cohort. Furthermore, Cox proportional hazards models were used to compute hazards ratios (HRs) and 95% confidence intervals (CIs) to estimate the correlation between KT and CRC in hemodialysis patients. Results The Kaplan–Meier analysis revealed that the cumulative incidence of CRC was significantly higher in the exposed cohort than in the non-exposed cohort (log-rank test, P < 0.001). After adjusting for potential confounders, the exposed cohort exhibited a significantly increased risk of CRC compared with the non-exposed cohort (adjusted HR, 1.34; 95% CI, 1.11–1.62). Conclusions Hemodialysis patients undergoing KT have a significantly higher risk of CRC than those not undergoing KT. Cancer should continue to be a primary focus of prevention during KT.

scholarly journals Post-transplant lymphoproliferative disorder following kidney transplantation: a population-based cohort study

2016 ◽  
Vol 29 (4) ◽  
pp. 483-493 ◽  
Author(s):  
Eva Futtrup Maksten ◽  
Maja Ølholm Vase ◽  
Jan Kampmann ◽  
Francesco d'Amore ◽  
Michael Boe Møller ◽  
...  
Keyword(s):  
Cohort Study ◽  
Kidney Transplantation ◽  
Lymphoproliferative Disorder ◽  
Population Based ◽  
Post Transplant

scholarly journals Supplemented Low-Protein Diet May Delay the Need for Preemptive Kidney Transplantation: A Nationwide Population-Based Cohort Study

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3002
Author(s):  
Chieh-Li Yen ◽  
Pei-Chun Fan ◽  
George Kuo ◽  
Chao-Yu Chen ◽  
Ya-Lien Cheng ◽  
...  
Keyword(s):  
Cohort Study ◽  
Kidney Transplantation ◽  
Adverse Events ◽  
Population Based ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Research Database ◽  
Post Transplantation ◽  
Low Protein ◽  
Preemptive Kidney Transplantation

Background: Although several studies suggest the benefit of a low-protein diet supplemented with amino acids and keto acids (sLPD) in delaying the initiation of hemodialysis, evidence on whether these nutritional approaches could delay the timing of preemptive transplantation is lacking. Methods: Retrospective nationwide cohort study, from Taiwan’s National Health Insurance Research Database. Patients having undergone a first preemptive kidney transplantation between 2001 and 2017 were identified and divided into two groups according to the presence of sLPD treatment or not. The primary outcome was the time between the diagnosis of advanced CKD and transplantation. Secondary outcomes were post-transplantation adverse events. Results: A total of 245 patients who received their first preemptive kidney transplantation were identified from the nationwide database; 63 of them had been on an sLPD prior to transplantation (sLPD group). The duration between the day of advanced CKD diagnosis and the day of transplantation was significantly longer in the sLPD group compared with the non-sLPD group (median duration: 345 vs. 220 days, p = 0.001). The risk of post-transplantation adverse events did not differ between the two groups. Conclusions: Within the limits of its observational, retrospective design, this is the first study to suggest that nutritional management with sLPDs can safely delay the timing of preemptive kidney transplantation.

Pre‐transplant maintenance dialysis duration and outcomes after kidney transplantation: A multicenter population‐based cohort study

2021 ◽  
Author(s):  
Kyla L. Naylor ◽  
S. Joseph Kim ◽  
John Paul Kuwornu ◽  
Stephanie N. Dixon ◽  
Amit X. Garg ◽  
...  
Keyword(s):  
Cohort Study ◽  
Kidney Transplantation ◽  
Population Based ◽  
Dialysis Duration ◽  
Maintenance Dialysis

scholarly journals Incidence of malignancy and related mortality after kidney transplantation: a nationwide, population-based cohort study in Korea

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Seri Jeong ◽  
Ho Sup Lee ◽  
Seom Gim Kong ◽  
Da Jung Kim ◽  
Sangjin Lee ◽  
...  
Keyword(s):  
Cohort Study ◽  
Kidney Transplantation ◽  
Hodgkin Lymphoma ◽  
De Novo ◽  
Kaposi Sarcoma ◽  
Premature Mortality ◽  
Population Based ◽  
Non Hodgkin Lymphoma ◽  
Kidney Recipients ◽  
Premature Deaths

AbstractPost-transplant malignancy (PTM) is a leading cause of premature mortality among kidney transplantation recipients. However, population-based cohort studies that cover incidence, mortality, and risk factors for PTM are rarely reported, especially in East Asia. We designed a retrospective cohort study using a national population-based database. A total of 9915 kidney recipients between 2003 and 2016 were included. During this period, 598 cases (6.0%) of de novo PTM occurred. The most common PTM was thyroid cancer (14.2%), followed by colorectal (11.2%), kidney (10.7%), and stomach cancers (8.9%). The standardised incidence ratio for all-site cancer was 3.9. The risks of Kaposi sarcoma (192.9) and kidney cancer (21.1) were more than 10 times those of the general population. Cancer-related deaths were 89 (14.9%) with liver cancer being the highest (14.6%), followed by lung cancer (13.5%), non-Hodgkin lymphoma (NHL) (12.4%), stomach cancer (9.0%), and colorectal cancer (7.9%). The standardised mortality ratio (SMR) was slightly elevated (1.4). A notable increase in SMR was observed for lymphoma (9.3 for Hodgkin lymphoma and 5.5 for NHL). Older age and graft failure were significantly related to PTM. These findings reflecting geographical variation have implications for the development of strategies for fatal cancers to prevent premature deaths from PTM.

Long-term outcomes during 37 years of pediatric kidney transplantation: a cohort study comparing ethnic groups

2021 ◽  
Author(s):  
Miriam Davidovits ◽  
Lewis Reisman ◽  
Roxana Cleper ◽  
Nathan Bar-Nathan ◽  
Irit Krause ◽  
...  
Keyword(s):  
Cohort Study ◽  
Kidney Transplantation ◽  
Ethnic Groups ◽  
Long Term Outcomes ◽  
Pediatric Kidney Transplantation
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