Cerebral Blood Flow is Lower in Youth with Type 2 Diabetes Compared to Obese Controls: A Pilot Study

2022 ◽  
Author(s):  
Jacob M. Redel ◽  
Mark DiFrancesco ◽  
Gregory R. Lee ◽  
Adi Ziv ◽  
Lawrence M. Dolan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Pilot Study

scholarly journals Resistance exercise and control of cerebral blood flow in type 2 diabetes

Diabetologia ◽  
2008 ◽  
Vol 51 (9) ◽  
pp. 1755-1756 ◽  
Author(s):  
Y. S. Kim ◽  
N. H. Secher ◽  
J. J. van Lieshout
Keyword(s):  
Type 2 Diabetes ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Resistance Exercise ◽  
And Control

Cerebral Blood Flow Abnormalities in Brain Regions Responsible for Cognitive Function in Type 2 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1798-P
Author(s):  
LEANNE HUNT ◽  
DINESH SELVARAJAH ◽  
SOLOMON TESFAYE ◽  
IAIN D. WILKINSON
Keyword(s):  
Type 2 Diabetes ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cognitive Function ◽  
Brain Regions

211-OR: Differential Cerebral Blood Flow in Controlled and Uncontrolled Patients with Type 2 Diabetes Mellitus

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 211-OR
Author(s):  
SARAH E. CHOI ◽  
BHASWATI ROY ◽  
MATTHEW FREEBY ◽  
RAJESH KUMAR
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Blood Flow ◽  
Type 2 Diabetes Mellitus ◽  
Cerebral Blood Flow

scholarly journals Intensive Blood Pressure Control Affects Cerebral Blood Flow in Type 2 Diabetes Mellitus Patients

Hypertension ◽  
2011 ◽  
Vol 57 (4) ◽  
pp. 738-745 ◽  
Author(s):  
Yu-Sok Kim ◽  
Shyrin C.A.T. Davis ◽  
Jasper Truijen ◽  
Wim J. Stok ◽  
Niels H. Secher ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Blood Flow ◽  
Type 2 Diabetes Mellitus ◽  
Cerebral Blood Flow ◽  
Blood Pressure Control ◽  
Pressure Control ◽  
Intensive Blood Pressure

scholarly journals IC-P-155: SEX-RELATED DIFFERENCES IN BRAIN VOLUMES AND CEREBRAL BLOOD FLOW AMONG OVERWEIGHT AND OBESE ADULTS WITH TYPE 2 DIABETES

2019 ◽  
Vol 15 ◽  
pp. P125-P125
Author(s):  
Owen T. Carmichael ◽  
Kathleen M. Hayden ◽  
Samuel N. Lockhart ◽  
Hussein N. Yassine ◽  
Siobhan M. Hoscheidt ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Obese Adults ◽  
Brain Volumes

scholarly journals P2-546: SEX-RELATED DIFFERENCES IN BRAIN VOLUMES AND CEREBRAL BLOOD FLOW AMONG OVERWEIGHT AND OBESE ADULTS WITH TYPE 2 DIABETES

2019 ◽  
Vol 15 ◽  
pp. P829-P830
Author(s):  
Owen T. Carmichael ◽  
Kathleen M. Hayden ◽  
Samuel N. Lockhart ◽  
Hussein N. Yassine ◽  
Siobhan M. Hoscheidt ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Obese Adults ◽  
Brain Volumes

Abnormal Rho-associated kinase activity contributes to the dysfunctional myogenic response of cerebral arteries in type 2 diabetes

2015 ◽  
Vol 93 (3) ◽  
pp. 177-184 ◽  
Author(s):  
Khaled S. Abd-Elrahman ◽  
Michael P. Walsh ◽  
William C. Cole
Keyword(s):  
Type 2 Diabetes ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Kinase Activity ◽  
Cerebral Arteries ◽  
Myogenic Response ◽  
Resistance Arteries ◽  
Blood Brain Barrier Disruption ◽  
Myogenic Regulation

The structural and functional integrity of the brain, and therefore, cognition, are critically dependent on the appropriate control of blood flow within the cerebral circulation. Inadequate flow leads to ischemia, whereas excessive flow causes small vessel rupture and (or) blood–brain-barrier disruption. Cerebral blood flow is controlled through the interplay of several physiological mechanisms that regulate the contractile state of vascular smooth muscle cells (VSMCs) within the walls of cerebral resistance arteries and arterioles. The myogenic response of cerebral VSMCs is a key mechanism that is responsible for maintaining constant blood flow during variations in systemic pressure, i.e., flow autoregulation. Inappropriate myogenic control of cerebral blood flow is associated with, and prognostic of, neurological deterioration and poor outcome in patients with several conditions, including type 2 diabetes. Here, we review recent advances in our understanding of the role of inappropriate Rho-associated kinase activity as a cause of impaired myogenic regulation of cerebral arterial diameter in type 2 diabetes.

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