Heterogeneity in the presentation of clinical type 1 diabetes defined by the level of risk conferred by HLA class II genotypes

2021 ◽  
Author(s):  
Antti‐Mathias Taka ◽  
Taina Härkönen ◽  
Paula Vähäsalo ◽  
Johanna Lempainen ◽  
Riitta Veijola ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Class Ii ◽  
Hla Class Ii ◽  
Clinical Type ◽  
Level Of Risk

Role of HLA Class II Loci Polymorphism in the Manifestation of Type 1 Diabetes in a Bengali Indian Patient Population

2013 ◽  
Vol 17 (1) ◽  
pp. 52-61 ◽  
Author(s):  
Oindrila Raha ◽  
Biswanath Sarkar ◽  
Pasumarthy Veerraju ◽  
Godi Sudhakar ◽  
Pradip Raychaudhuri ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Patient Population ◽  
Class Ii ◽  
Hla Class Ii ◽  
Indian Patient

Association of HLA Class II Alleles and Haplotypes with Type 1 Diabetes in Tunisian Arabs

2018 ◽  
Vol 127 (10) ◽  
pp. 653-662
Author(s):  
Abdelhafidh Hajjej ◽  
Wassim Y. Almawi ◽  
Mouna Stayoussef ◽  
Lasmar Hattab ◽  
Slama Hmida
Keyword(s):  
Type 1 Diabetes ◽  
Association Studies ◽  
Class Ii ◽  
Correlation Study ◽  
Case Control ◽  
Linkage Study ◽  
Hla Class Ii ◽  
Racial Background ◽  
Family Based

AbstractThe molecular association of HLA class II with type 1 diabetes (T1DM) was investigated in Tunisian Arabs using 3 kinds of analyses. The first was a case-control association study, using Relative Predispositional Effects method, involved 137 T1DM cases and 258 control subjects. The second was family-based association-linkage study, using Transmission Disequilibrium Test, and covering 50 Tunisian families comprising 73 T1DM patients and 100 parents. The third was a wide correlation study between 4 DRB1 alleles (DRB1*03, *04, *11, *15) and T1DM in 52 countries, using Spearman’s Rho. Results from Case-control and family-based association studies showed that DRB1*03 and DRB1*04 alleles predispose to T1DM in Tunisian Arabs. Conversely, only DRB1*11 was protective for T1DM. DRB1*04-DQB1*03 haplotype was consistently associated positively with T1DM; DRB1*03/DRB1*04 genotype had the highest risk of T1DM development. Compared to DRB1*03, HLA-DRB1*04 was associated with higher T1DM incidence. Thus, the contribution of HLA class II to T1DM genetic susceptibility must be evaluated with regards to specific HLA alleles, genotypes, and haplotypes, and also ethnic and racial background.

scholarly journals Susceptible and Protective Human Leukocyte Antigen Class II Alleles and Haplotypes in Bahraini Type 2 (Non-Insulin-Dependent) Diabetes Mellitus Patients

2005 ◽  
Vol 12 (1) ◽  
pp. 213-217 ◽  
Author(s):  
Ayesha A. Motala ◽  
Marc Busson ◽  
Einas M. Al-Harbi ◽  
Manal A. A. Khuzam ◽  
Emtiaz M. D. Al-Omari ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Class Ii ◽  
Hla Class Ii ◽  
Leukocyte Antigen ◽  
Insulin Dependent

ABSTRACT Whereas the genetic risk for type 1 diabetes is linked to human leukocyte antigen (HLA) class II genes, the HLA association in type 2 (non-insulin-dependent) diabetes is less clear. The association between HLA class II genotypes and type 2 diabetes was examined in adult Bahrainis, an Arab population with a high prevalence of type 2 diabetes. HLA-DRB1* and -DQB1* genotyping of 86 unrelated type 2 diabetes patients (age, 51.6 ± 8.2 years; mean duration of diabetes, 7.7 ± 7.1 years) who had a strong family history of diabetes (52 of 72 versus 0 of 89 for controls, P < 0.001) and 89 healthy subjects was done by PCR-sequence-specific priming. DRB1*040101 (0.1221 versus 0.0562, P = 0.019) and DRB1*070101 (0.2151 versus 0.0843, P < 0.001) were positively associated, while DRB1*110101 (0.0698 versus 0.1461, P = 0.014) and DRB1*160101 (0.0640 versus 0.1236, P = 0.038) were negatively associated with type 2 diabetes. DRB1*040101-DQB1*0302 (0.069 versus 0.0007; P = 0.004), DRB1*070101-DQB1*0201 (0.178 versus 0.0761, P = 0.007), DRB1*070101-DQB1*050101 (0.125 versus 0.0310, P = 0.002), and DRB1*150101-DQB1*060101 (0.0756 versus 0.0281, P = 0.008) were more prevalent among patients, while DRB1*160101-DQB1*050101 (0.0702 versus 0.0349, P = 0.05) was more prevalent among controls, conferring disease susceptibility or protection, respectively. In Bahrainis with type 2 diabetes, there is a significant association with select HLA class II genotypes, which were distinct from those in type 1 diabetes.

HLA Class II Allele Analyses Implicate Common Genetic Components in Type 1 and Non–Insulin-Treated Type 2 Diabetes

2020 ◽  
Vol 105 (3) ◽  
pp. e245-e254 ◽  
Author(s):  
Thomas Jacobi ◽  
Lucas Massier ◽  
Nora Klöting ◽  
Katrin Horn ◽  
Alexander Schuch ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Class Ii ◽  
Hla Class Ii ◽  
Risk Haplotype ◽  
Genetic Components ◽  
Hla Genotypes ◽  
Increased Risk

Abstract Context Common genetic susceptibility may underlie the frequently observed co-occurrence of type 1 and type 2 diabetes in families. Given the role of HLA class II genes in the pathophysiology of type 1 diabetes, the aim of the present study was to test the association of high density imputed human leukocyte antigen (HLA) genotypes with type 2 diabetes. Objectives and Design Three cohorts (Ntotal = 10 413) from Leipzig, Germany were included in this study: LIFE-Adult (N = 4649), LIFE-Heart (N = 4815) and the Sorbs (N = 949) cohort. Detailed metabolic phenotyping and genome-wide single nucleotide polymorphism (SNP) data were available for all subjects. Using 1000 Genome imputation data, HLA genotypes were imputed on 4-digit level and association tests for type 2 diabetes, and related metabolic traits were conducted. Results In a meta-analysis including all 3 cohorts, the absence of HLA-DRB5 was associated with increased risk of type 2 diabetes (P = 0.001). In contrast, HLA-DQB*06:02 and HLA-DQA*01:02 had a protective effect on type 2 diabetes (P = 0.005 and 0.003, respectively). Both alleles are part of the well-established type 1 diabetes protective haplotype DRB1*15:01~DQA1*01:02~DQB1*06:02, which was also associated with reduced risk of type 2 diabetes (OR 0.84; P = 0.005). On the contrary, the DRB1*07:01~DQA1*02:01~DQB1*03:03 was identified as a risk haplotype in non–insulin-treated diabetes (OR 1.37; P = 0.002). Conclusions Genetic variation in the HLA class II locus exerts risk and protective effects on non–insulin-treated type 2 diabetes. Our data suggest that the genetic architecture of type 1 diabetes and type 2 diabetes might share common components on the HLA class II locus.

The distribution of HLA class II susceptible/protective haplotypes could partially explain the low incidence of type 1 diabetes in continental Italy (Lazio region)

2001 ◽  
Vol 58 (6) ◽  
pp. 385-394 ◽  
Author(s):  
A. Petrone ◽  
T.L. Bugawan ◽  
C.A. Mesturino ◽  
L. Nisticò ◽  
A. Galgani ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Class Ii ◽  
Hla Class Ii ◽  
Lazio Region ◽  
Low Incidence

scholarly journals HLA class II is a factor in cardiovascular morbidity and mortality rates in patients with type 1 diabetes

Diabetologia ◽  
2012 ◽  
Vol 55 (11) ◽  
pp. 2963-2969 ◽  
Author(s):  
J. Söderlund ◽  
◽  
C. Forsblom ◽  
J. Ilonen ◽  
L. M. Thorn ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Mortality Rates ◽  
Class Ii ◽  
Hla Class Ii ◽  
Cardiovascular Morbidity ◽  
Morbidity And Mortality ◽  
Cardiovascular Morbidity And Mortality

scholarly journals HLA class II gene associations in African American Type 1 diabetes reveal a protective HLA‐DRB1*03 haplotype

2013 ◽  
Vol 30 (6) ◽  
pp. 710-716 ◽  
Author(s):  
J. M. M. Howson ◽  
M. S. Roy ◽  
L. Zeitels ◽  
H. Stevens ◽  
J. A. Todd
Keyword(s):  
Type 1 Diabetes ◽  
African American ◽  
Class Ii ◽  
Hla Class Ii ◽  
Gene Associations
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