Clinical characteristics, growth patterns, and long‐term diabetes complications of 24 patients with neonatal diabetes mellitus: a single center experience

2021 ◽  
Author(s):  
Marie Mouler ◽  
Yael Lebenthal ◽  
Liat Vries ◽  
Michal Yackobovitch‐Gavan ◽  
Noa Sheffer Averbuch ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Characteristics ◽  
Diabetes Complications ◽  
Neonatal Diabetes ◽  
Growth Patterns ◽  
Neonatal Diabetes Mellitus ◽  
Single Center ◽  
Single Center Experience

Improved long-term glucose control in neonatal diabetes mellitus after early sulfonylurea allergy

2012 ◽  
Vol 25 (3-4) ◽  
Author(s):  
Bina Shah ◽  
Emily Breidbart ◽  
Melissa Pawelczak ◽  
Leslie Lam ◽  
Marion Kessler ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Control ◽  
Neonatal Diabetes ◽  
Neonatal Diabetes Mellitus

scholarly journals Molecular Genetics, Clinical Characteristics, and Treatment Outcomes of KATP-Channel Neonatal Diabetes Mellitus in Vietnam National Children’s Hospital

2021 ◽  
Vol 12 ◽  
Author(s):  
Can Thi Bich Ngoc ◽  
Tran Minh Dien ◽  
Elisa De Franco ◽  
Sian Ellard ◽  
Jayne A. L. Houghton ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Genetic Testing ◽  
Glycemic Control ◽  
Molecular Genetics ◽  
Clinical Characteristics ◽  
Neonatal Diabetes ◽  
Neonatal Diabetes Mellitus ◽  
Common Cause ◽  
Children's Hospital

BackgroundNeonatal diabetes mellitus (NDM) is defined as insulin-requiring persistent hyperglycemia occurring within the first 6 months of life, which can result from mutations in at least 25 different genes. Activating heterozygous mutations in genes encoding either of the subunits of the ATP-sensitive K+ channel (KATP channel; KCNJ11 or ABCC8) of the pancreatic beta cell are the most common cause of permanent NDM and the second most common cause of transient NDM. Patients with NDM caused by KATP channel mutations are sensitive to sulfonylurea (SU) treatment; therefore, their clinical management can be improved by replacing insulin with oral agents.Patients and MethodsSeventy patients were diagnosed with NDM between May 2008 and May 2021 at Vietnam National Children’s Hospital, and molecular genetic testing for all genes known to cause NDM was performed at the Exeter Genomic Laboratory, UK. Patients with ABCC8 or KCNJ11 mutations were transferred from insulin to oral SU. Clinical characteristics, molecular genetics, and annual data relating to glycemic control, SU dose, severe hypoglycemia, and side effects were collected. The main outcomes of interest were SU dose, SU failure (defined as permanent reintroduction of daily insulin), and glycemic control (HbA1c).ResultsFifty-four of 70 patients (77%) with NDM harbored a genetic mutation and of these; 27 (50%) had activating heterozygous mutations in ABCC8 or KCNJ11. A total of 21 pathogenic mutations were identified in the 27 patients, including 13 mutations in ABCC8 and 8 mutations in KCNJ11. Overall, 51% had low birth weight (below 3rd percentile), 23 (85%) were diagnosed before 3 months of age, and 23 (85%) presented with diabetic ketoacidosis. At diagnosis, clinical and biochemical findings (mean ± SD) were pH 7.16 ± 0.16; HCO3−, 7.9 ± 7.4 mmol/L; BE, −17.9 ± 9.1 mmol/L; HbA1C, 7.98% ± 2.93%; blood glucose, 36.2 ± 12.3 mmol/L; and C-peptide median, 0.09 (range, 0–1.61 nmol/l). Twenty-six patients were successfully transferred from insulin to SU therapy. In the remaining case, remission of diabetes occurred prior to transfer. Glycemic control on SU treatment was better than on insulin treatment: HbA1c and blood glucose level decreased from 7.58% ± 4.63% and 19.04 ± 14.09 mmol/L when treated with insulin to 5.8 ± 0.94% and 6.87 ± 3.46 mmol/L when treated with SU, respectively.ConclusionsThis is the first case series of NDM patients with ABCC8/KCNJ11 mutations reported in Vietnam. SU is safe in the short term for these patients and more effective than insulin therapy, consistent with all studies to date. This is relevant for populations where access to and cost of insulin are problematic, reinforcing the importance of genetic testing for NDM.

Glycemic Control and Long-term Complications in Pediatric Onset Type 1 Diabetes Mellitus: A Single-center Experience from Northern India

2019 ◽  
Vol 56 (3) ◽  
pp. 191-195 ◽  
Author(s):  
Siddhnath Sudhanshu ◽  
Veena V Nair ◽  
Tushar Godbole ◽  
S Vijay Bhaskar Reddy ◽  
Eesh Bhatia ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Type 1 Diabetes Mellitus ◽  
Single Center ◽  
Northern India ◽  
Single Center Experience ◽  
Pediatric Onset

scholarly journals Demographic and Clinical Characteristics of Type 1 Diabetes Mellitus in Omani Children - Single Center Experience

2014 ◽  
Vol 29 (2) ◽  
pp. 119-122 ◽  
Author(s):  
Saif Al-Yaarubi ◽  
Irfan Ullah ◽  
Sharef Waadallah Sharef ◽  
Azza Al Shidhani ◽  
Shaima Al Hanai ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Clinical Characteristics ◽  
Single Center ◽  
Single Center Experience

Clinical characteristics and long-term outcome of diarrhea-associated hemolytic uremic syndrome: a single center experience

2017 ◽  
Vol 21 (5) ◽  
pp. 889-894 ◽  
Author(s):  
Takeshi Ninchoji ◽  
Kandai Nozu ◽  
Keita Nakanishi ◽  
Tomoko Horinouchi ◽  
Junya Fujimura ◽  
...  
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Clinical Characteristics ◽  
Single Center ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Single Center Experience ◽  
Uremic Syndrome

Clinical Characteristics and Long-Term Outcomes of Patients Undergoing Combined Heart-Kidney Transplantation: A Single-Center Experience

2015 ◽  
Vol 47 (1) ◽  
pp. 123-126 ◽  
Author(s):  
Á. López-Sainz ◽  
E. Barge-Caballero ◽  
M.J. Paniagua-Martin ◽  
R. Marzoa Rivas ◽  
G. Sánchez-Fernández ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Clinical Characteristics ◽  
Single Center ◽  
Long Term Outcomes ◽  
Single Center Experience
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