Homozygosity of the Z‐2 polymorphic variant in the aldose reductase gene promoter confers increased risk for neuropathy in children and adolescents with type 1 diabetes

2021 ◽  
Author(s):  
Dimitra Kallinikou ◽  
Charalampos Tsentidis ◽  
Kyriaki Kekou ◽  
Marina Katsalouli ◽  
Maria Louraki ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Aldose Reductase ◽  
Gene Promoter ◽  
Polymorphic Variant ◽  
Increased Risk ◽  
Reductase Gene

Carotid intima media thickness and associations with serum osteoprotegerin and s-RANKL in children and adolescents with type 1 diabetes mellitus with increased risk for endothelial dysfunction

2018 ◽  
Vol 0 (0) ◽  
Author(s):  
Kyriaki Karavanaki ◽  
Emmanouil Tsouvalas ◽  
Marina Vakaki ◽  
Alexandra Soldatou ◽  
Charalambos Tsentidis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Endothelial Dysfunction ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Negatively Associated ◽  
Increased Risk

Abstract Background Although carotid intima media thickness (CIMT) is an established marker of endothelial dysfunction, limited data exist on relative laboratory biomarkers in youngsters with type 1 diabetes mellitus (T1DM). Our aim was to study CIMT and the biomarkers of the osteoprotegerin (OPG)/RANKL system in young T1DM patients and controls, and also in subgroups of patients with increased risk for endothelial dysfunction, such as those with overweight/obesity, poor metabolic control or the presence of microalbuminuria. Methods CIMT and OPG/RANKL of 56 T1DM children and adolescents were compared to 28 healthy controls. Results Anthropometric, laboratory, CIMT and OPG/RANKL measurements were similar between patients and controls. Overweight/obese patients had greater CIMT than the normal weight ones (0.50 vs. 0.44 mm, p=0.001). Microalbuminuric patients had greater CIMT (0.49 vs. 0.44 mm, p=0.035) than the normoalbuminuric ones, with no difference in terms of OPG/RANKL. In the microalbuminuric group, OPG (r=−0.90, p=0.036) and RANKL (r=−0.92, p=0.024) were significantly negatively associated with CIMT. Following linear regression analysis, in the total patients group, microalbuminuria was the only factor significantly associated with CIMT (beta±SE: 0.050±0.021, p=0.035), body mass index (BMI)-z-scores were negatively associated with OPG (beta±SE: −0.25±0.12, p=0.05), while in the microalbuminuric group, CIMT was negatively associated with OPG (beta±SE: −0.070±0.019, p=0.036). During the forward stepwise procedure, microalbuminuria and age were the only variables negatively associated with RANKL (b=−0.334, p=0.034, b=−35.95, p=0.013, respectively). Conclusions In T1DM pediatric patients, overweight/obesity and microalbuminuria were associated with greater CIMT and with impaired OPG/RANKL levels, as biochemical indices of calcification of the atherosclerotic plaque.

scholarly journals Experiences From a Coaching Program for Parents of Children and Adolescents With Type 1 Diabetes Developed Through Experienced-Based Co-Design (EBCD)

2020 ◽  
Vol 7 (6) ◽  
pp. 1181-1188
Author(s):  
Kerstin Ramfelt ◽  
Christina Petersson ◽  
Karin Åkesson
Keyword(s):  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Qualitative Content Analysis ◽  
Pediatric Diabetes ◽  
Increased Risk ◽  
The Family ◽  
Parental Coaching ◽  
Coach Program

Many children and adolescents with type 1 diabetes (T1D) have difficulties reaching the national treatment goal for HbA1c (long-term blood sugar) which is associated with increased risk for complications. This makes it important to explore what patients and their caregivers describe important in coping with everyday life. The study has been conducted within a pediatric diabetes team in the south of Sweden. The aim was to explore how Experienced-Based Co-Design (EBCD) can be used to identify, test, and evaluate improvement efforts in order to support the family with a child with T1D. A modified variant of EBCD based on focus groups, workshops, and interviews with stakeholders was used. The improvement proposal parental coaching was tested and was appreciated by the participants. The qualitative content analysis of the interviews showed that the coaching program contributed to better confidence and self-efficacy. Both coaches and coachees described that the coaching contributed to better competence and a feeling of hope after attending the coach program. Experienced-Based Co-Design gave an opportunity to explore what´s important to improve, based on experiences and needs of several stakeholders.

Biphasic Insulin Aspart 30 Treatment Option in Children and Adolescents

2006 ◽  
Vol 00 (02) ◽  
Author(s):  
Patrick Lemoine
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Children And Adolescents ◽  
Metabolic Disturbances ◽  
Chronic Hyperglycemia ◽  
Strict Glycemic Control ◽  
Biphasic Insulin Aspart 30 ◽  
Increased Risk

Type 1 diabetes is a chronic metabolic disease that is characterized by absolute insulin deficiency, which leads to chronic hyperglycemia, as well as other metabolic disturbances. Thus, children with diabetes are at increased risk for developing progressive longterm microvascular (e.g. retinopathy, nephropathy, and neuropathy) and macrovascular (e.g. cerebral, coronary and peripheral vascular disease) complications. The importance of strict glycemic control via intensive insulin therapy has been demonstrated in children and adolescents with type 1 diabetes. Although advanced diabetic complications are rare in children and adolescents, follow-up studies from the Diabetes Control and Complications Trial Cohort have provided unquestionable evidence in support of implementing strict glycemic control in all individuals with diabetes as early as possible.

Aldose reductase gene polymorphisms and susceptibility to diabetic nephropathy in Type 1 diabetes mellitus

2000 ◽  
Vol 17 (2) ◽  
pp. 111-118 ◽  
Author(s):  
D. K. Moczulski ◽  
L. Scott ◽  
A. Antonellis ◽  
J. J. Rogus ◽  
S. S. Rich ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Diabetic Nephropathy ◽  
Type 1 Diabetes Mellitus ◽  
Aldose Reductase ◽  
Gene Polymorphisms ◽  
Reductase Gene

Immune status is associated with the mode of delivery in infants at increased risk for Type 1 Diabetes

2014 ◽  
Vol 9 (S 01) ◽  
Author(s):  
O D'Orlando ◽  
R Puff ◽  
A Henniger ◽  
S Krause ◽  
F Haupt ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Immune Status ◽  
Mode Of Delivery ◽  
Increased Risk

Bone status of Indian children and adolescents with type 1 diabetes mellitus

2013 ◽  
Author(s):  
Parthasarathy Lavanya ◽  
Khadilkar Anuradha ◽  
Ekbote Veena ◽  
Chiplonkar Shashi ◽  
Mughal Zulf ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Indian Children ◽  
Bone Status
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