scholarly journals Delayed referral is common even when new‐onset diabetes is suspected in children. A Swedish prospective observational study of diabetic ketoacidosis at onset of type 1 diabetes

2021 ◽  
Author(s):  
Johan H. Wersäll ◽  
Peter Adolfsson ◽  
Gun Forsander ◽  
Sven‐Erik Ricksten ◽  
Ragnar Hanas
Keyword(s):  
Type 1 Diabetes ◽  
Observational Study ◽  
Diabetic Ketoacidosis ◽  
Prospective Observational Study ◽  
Onset Diabetes ◽  
Delayed Referral ◽  
New Onset

Delayed referral of new‐onset type 1 diabetes increases the risk of diabetic ketoacidosis

2009 ◽  
Vol 190 (4) ◽  
pp. 219-219 ◽  
Author(s):  
Maria E Craig ◽  
Catherine H Wong ◽  
Joanna Alexander ◽  
Ann M Maguire ◽  
Martin Silink
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Ketoacidosis ◽  
Onset Type ◽  
Delayed Referral ◽  
New Onset

66-LB: Greater Time Spent in Hypoglycemia during Night Compared with Day during Intensified Training in Professional Cyclists with Type 1 Diabetes—A Prospective Observational Study

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 66-LB ◽  
Author(s):  
OTHMAR MOSER ◽  
MAX L. ECKSTEIN ◽  
OLIVIA MCCARTHY ◽  
MICHAEL RIDDELL ◽  
FEDERICO Y. FONTANA ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Observational Study ◽  
Prospective Observational Study

scholarly journals COVID-19 Infection with Refractory Diabetic Ketoacidosis- A case Report

2021 ◽  
Vol 7 (2) ◽  
pp. 54-56
Author(s):  
Reshmi Mishra ◽  
◽  
Jyoti Ranjan Behera ◽  
P. Ramkumar ◽  
Mukesh Kumar Jain ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Metabolic Acidosis ◽  
Diabetic Ketoacidosis ◽  
Vital Organ ◽  
Increased Risk ◽  
Life Threatening ◽  
Life Threatening Complication ◽  
New Onset

Diabetic ketoacidosis is an acute life-threatening complication of type 1 diabetes. Sometimes it is the first presentation in an undiagnosed child. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) and diabetes mellitus are very much interrelated as diabetes mellitus is associated with an increased risk of severe COVID19 at the same time, many cases of new-onset diabetes had been diagnosed. Hyperglycemia, metabolic acidosis, and ketonemia are classical presentations. It is essential to correct the acidosis and fluid correction and insulin therapy in these patients, leading to vital organ dysfunction. In refractory metabolic acidosis, renal replacement therapy may help

scholarly journals New-Onset Type 1 Diabetes Mellitus with Diabetic Ketoacidosis and Pancreatitis in a Patient with COVID-19

2021 ◽  
pp. e00915
Author(s):  
Mostafa Alfishawy ◽  
Mahmoud Nassar ◽  
Mahmoud Mohamed ◽  
Moataz Fatthy ◽  
Riem El Messiery
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Diabetic Ketoacidosis ◽  
Onset Type ◽  
New Onset

scholarly journals Incidence of COVID-19 and Risk of Diabetic Ketoacidosis in New-Onset Type 1 Diabetes

PEDIATRICS ◽  
2021 ◽  
pp. e2021050856
Author(s):  
Clemens Kamrath ◽  
Joachim Rosenbauer ◽  
Alexander J. Eckert ◽  
Angeliki Pappa ◽  
Felix Reschke ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Ketoacidosis ◽  
Onset Type ◽  
New Onset

An unusual presentation of primary adrenal insufficiency with new onset type 1 diabetes: case report and review of the literature

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Shelby Graf ◽  
Rachel Stork Poeppelman ◽  
Jennifer McVean ◽  
Arpana Rayannavar ◽  
Muna Sunni
Keyword(s):  
Type 1 Diabetes ◽  
Adrenal Insufficiency ◽  
Diabetic Ketoacidosis ◽  
Serum Cortisol ◽  
Unusual Presentation ◽  
Primary Adrenal Insufficiency ◽  
Onset Type ◽  
Autoimmune Conditions ◽  
New Onset

Abstract Objectives To describe an atypical presentation of primary adrenal insufficiency in conjunction with new onset type 1 diabetes. Case presentation Here, we describe a case of new-onset type 1 diabetes (T1D) presenting simultaneously with an unusual presentation of primary adrenal insufficiency in a previously healthy 16-year-old. He was admitted for a typical presentation of diabetic ketoacidosis, but with extreme hyponatremia. An extensive workup revealed a low aldosterone level, appropriate cortisol level, and positive 21-hydroxylase antibodies. While the phenomenon of multiple autoimmune conditions developing in the same patient is well-described, this particular case has several atypical aspects. Our patient’s case highlights the danger of relying on random serum cortisol in the setting of acute illness to rule out adrenal insufficiency. Conclusions Adrenal insufficiency can present as isolated hypoaldosteronism without hypocortisolemia and can manifest as severe hyponatremia in the context of diabetic ketoacidosis. Workup for an unusual presentation of T1D should include a 21-hydroxylase antibody, as well as thyroid and celiac disease studies.

Diabetic ketoacidosis at the onset of disease during a national awareness campaign: a 2-year observational study in children aged 0–18 years

2019 ◽  
Vol 105 (4) ◽  
pp. 363-366 ◽  
Author(s):  
Ivana Rabbone ◽  
Giulio Maltoni ◽  
Davide Tinti ◽  
Stefano Zucchini ◽  
Valentino Cherubini ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Observational Study ◽  
Diabetic Ketoacidosis ◽  
Pediatric Endocrinology ◽  
Previous Survey ◽  
Awareness Campaign ◽  
Prevention Campaign ◽  
National Prevention ◽  
Original Survey

ObjectiveAfter a previous survey on the incidence of diabetic ketoacidosis (DKA) at onset of type 1 diabetes in children in 2013–2014 in Italy, we aimed to verify a possible decline in the incidence of DKA at onset during a national prevention campaign.DesignProspective observational study.SettingMulticentre study throughout Italy.InterventionNational awareness campaign started in November 2015 and held until December 2017.PatientsDuring 2016 and 2017 we collected data on all patients aged 0–18 years with new-onset diabetes.Main outcome measuresDKA (pH <7.30), severe DKA (pH <7.1), DKA in children below 6 years and DKA treatment according to the Italian Society for Pediatric Endocrinology and Diabetology (ISPED) protocol were evaluated.ResultsRecords (n=2361) of children with newly diagnosed type 1 diabetes were collected from 58 out of 68 (85.3%) centres of the original survey participants and 100% of the previously surveyed tertiary centres. Overall, DKA was observed in 1124 patients, with an increased rate when compared with the previous survey (47.6% vs 38.5%, p=0.002), and severe DKA in 15.3%. In children below 6 years, DKA was observed in 323 out of 617 (52.5%) and severe DKA in 16.7%; in this age group, occurrence of DKA reduced by 21.3% (p=0.009). DKA treatment according to the ISPED guidelines was adopted in 95% of the centres, with a 27% improvement (p=0.025).ConclusionsDuring a 2-year awareness campaign, DKA at onset of diabetes in children and adolescents 0–18 years is still common and increased when compared with the 2013–2014 survey.

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