Left ventricular functions in pediatric patients with ten years or more type 1 diabetes mellitus: Conventional echocardiography, tissue Doppler, and two‐dimensional speckle tracking study

2019 ◽  
Vol 20 (7) ◽  
pp. 946-954 ◽  
Author(s):  
Shaimaa Rakha ◽  
Hadil M. Aboelenin
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Speckle Tracking ◽  
Pediatric Patients ◽  
Tissue Doppler ◽  
Left Ventricular ◽  
Two Dimensional ◽  
Conventional Echocardiography

scholarly journals Subclinical Alterations of Cardiac Mechanics Present Early in the Course of Pediatric Type 1 Diabetes Mellitus: A Prospective Blinded Speckle Tracking Stress Echocardiography Study

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Kai O. Hensel ◽  
Franziska Grimmer ◽  
Markus Roskopf ◽  
Andreas C. Jenke ◽  
Stefan Wirth ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Strain Rate ◽  
Type 1 Diabetes Mellitus ◽  
Speckle Tracking ◽  
Stress Testing ◽  
Disease Duration ◽  
Left Ventricular ◽  
Pathophysiological Mechanism

Diabetic cardiomyopathy substantially accounts for mortality in diabetes mellitus. The pathophysiological mechanism underlying diabetes-associated nonischemic heart failure is poorly understood and clinical data on myocardial mechanics in early stages of diabetes are lacking. In this study we utilize speckle tracking echocardiography combined with physical stress testing in order to evaluate whether left ventricular (LV) myocardial performance is altered early in the course of uncomplicated type 1 diabetes mellitus (T1DM). 40 consecutive asymptomatic normotensive children and adolescents with T1DM (mean age11.5±3.1years and mean disease duration4.3±3.5years) and 44 age- and gender-matched healthy controls were assessed using conventional and quantitative echocardiography (strain and strain rate) during bicycle ergometer stress testing. Strikingly, T1DM patients had increased LV longitudinal (p=0.019) and circumferential (p=0.016) strain rate both at rest and during exercise (p=0.021). This was more pronounced in T1DM patients with a longer disease duration (p=0.038). T1DM patients with serumHbA1c>9%showed impaired longitudinal (p=0.008) and circumferential strain (p=0.005) and a reduced E/A-ratio (p=0.018). In conclusion, asymptomatic T1DM patients have signs of hyperdynamic LV contractility early in the course of the disease. Moreover, poor glycemic control is associated with early subclinical LV systolic and diastolic impairment.

scholarly journals Two-Dimensional Speckle Tracking Versus Applanation Tonometry in Evaluation of Subclinical Atherosclerosis in Children with Type 1 Diabetes Mellitus

2019 ◽  
Vol 25 ◽  
pp. 7289-7294 ◽  
Author(s):  
Michał Podgórski ◽  
Katarzyna Szatko ◽  
Małgorzata Stańczyk ◽  
Monika Pawlak-Bratkowska ◽  
Michał Fila ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Speckle Tracking ◽  
Subclinical Atherosclerosis ◽  
Applanation Tonometry ◽  
Two Dimensional
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