Insulin function in obese children within the low and high ranges of impaired fasting glycemia

2018 ◽  
Author(s):  
Emilia Hagman ◽  
Anna E Ek ◽  
Claude Marcus
Keyword(s):  
Obese Children ◽  
Fasting Glycemia ◽  
Impaired Fasting Glycemia

Use of new ADA and WHO criteria for the diagnosis of impaired fasting glycemia and diabetes in kidney graft recipients

2002 ◽  
Vol 39 (3) ◽  
pp. 129-130
Author(s):  
M. Aragona ◽  
R. Giannarelli ◽  
A. Coppelli ◽  
S. Del Prato ◽  
P. Marchetti ◽  
...  
Keyword(s):  
Kidney Graft ◽  
Who Criteria ◽  
Fasting Glycemia ◽  
Impaired Fasting Glycemia

scholarly journals Diabetes and Impaired Fasting Glycemia in a Rural Population of Bangladesh

Diabetes Care ◽  
2003 ◽  
Vol 26 (4) ◽  
pp. 1034-1039 ◽  
Author(s):  
M. A. Sayeed ◽  
H. Mahtab ◽  
P. A. Khanam ◽  
Z. A. Latif ◽  
S. M. K. Ali ◽  
...  
Keyword(s):  
Rural Population ◽  
Fasting Glycemia ◽  
Impaired Fasting Glycemia

scholarly journals Logistic model of glucose-regulated C-peptide secretion: hysteresis pathway disruption in impaired fasting glycemia

2012 ◽  
Vol 303 (3) ◽  
pp. E397-E409 ◽  
Author(s):  
Daniel M. Keenan ◽  
Rita Basu ◽  
Yan Liu ◽  
Ananda Basu ◽  
Gerlies Bock ◽  
...  
Keyword(s):  
Dose Response ◽  
Maximal Effect ◽  
Deconvolution Analysis ◽  
C Peptide ◽  
Fasting Glycemia ◽  
Glucose Stimulated Insulin Secretion ◽  
Recovery Pathways ◽  
Peptide Secretion ◽  
Impaired Fasting Glycemia

The present analysis tests the hypothesis that quantifiable disruption of the glucose-stimulated insulin-secretion dose-response pathway mediates impaired fasting glycemia (IFG) and type 2 diabetes mellitus (DM). To this end, adults with normal and impaired fasting glycemia (NFG, n = 30), IFG ( n = 32), and DM ( n = 14) were given a mixed meal containing 75 g glucose. C-peptide and glucose were measured over 4 h, 13 times in NFG and IFG and 16 times in DM (age range 50–57 yr, body mass index 28–32 kg/m2). Wavelet-based deconvolution analysis was used to estimate time-varying C-peptide secretion rates. Logistic dose-response functions were constructed analytically of the sensitivity, potency, and efficacy (in the pharmacological sense of slope, one-half maximal stimulation, and maximal effect) of glucose's stimulation of prehepatic insulin (C-peptide) secretion. A hysteresis changepoint time, demarcating unequal glucose potencies for onset and recovery pathways, was estimated simultaneously. According to this methodology, NFG subjects exhibited distinct onset and recovery potencies of glucose in stimulating C-peptide secretion (6.5 and 8.5 mM), thereby defining in vivo hysteresis (potency shift −2.0 mM). IFG patients manifested reduced glucose onset potency (8.6 mM), and diminished C-peptide hysteretic shift (−0.80 mM). DM patients had markedly decreased glucose potency (18.8 mM), reversal of C-peptide's hysteretic shift (+4.5 mM), and 30% lower C-peptide sensitivity to glucose stimulation. From these data, we conclude that a dynamic dose-response model of glucose-dependent control of C-peptide secretion can identify disruption of in vivo hysteresis in patients with IFG and DM. Pathway-defined analytic models of this kind may aid in the search for prediabetes biomarkers.

scholarly journals Disturbances in  -Cell Function in Impaired Fasting Glycemia

Diabetes ◽  
2002 ◽  
Vol 51 (Supplement 1) ◽  
pp. S265-S270 ◽  
Author(s):  
T. W. van Haeften ◽  
W. Pimenta ◽  
A. Mitrakou ◽  
M. Korytkowski ◽  
T. Jenssen ◽  
...  
Keyword(s):  
Cell Function ◽  
Fasting Glycemia ◽  
Impaired Fasting Glycemia

scholarly journals Diabetes and Impaired Fasting Glycemia in the Tribes of Khagrachari Hill Tracts of Bangladesh

Diabetes Care ◽  
2004 ◽  
Vol 27 (5) ◽  
pp. 1054-1059 ◽  
Author(s):  
M. A. Sayeed ◽  
H. Mahtab ◽  
P. A. Khanam ◽  
K. A. Ahsan ◽  
A. Banu ◽  
...  
Keyword(s):  
Fasting Glycemia ◽  
Impaired Fasting Glycemia

Prevalence of prediabetes in Kashmir valley using revised ADA criteria for impaired fasting glycemia

2006 ◽  
Vol 72 (3) ◽  
pp. 329-330 ◽  
Author(s):  
Abdul Hamid Zargar ◽  
Mir Iftikhar Bashir ◽  
Shariq Rashid Masoodi ◽  
Arshad Iqbal Wani ◽  
Ajaz Kariem Khan
Keyword(s):  
Kashmir Valley ◽  
Fasting Glycemia ◽  
Impaired Fasting Glycemia
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