Early atherosclerosis is associated with retinal microvascular changes in adolescents with type 1 diabetes

2018 ◽  
Vol 19 (8) ◽  
pp. 1467-1470 ◽  
Author(s):  
Alexia S. Peña ◽  
Gerald Liew ◽  
Jemma Anderson ◽  
Lynne C. Giles ◽  
Roger Gent ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Microvascular Changes ◽  
Early Atherosclerosis

The association of early atherosclerosis and retinopathy in adolescents with type 1 diabetes: preliminary report

2007 ◽  
Vol 44 (3) ◽  
pp. 131-137 ◽  
Author(s):  
B. Głowińska-Olszewska ◽  
M. Urban ◽  
B. Urban ◽  
J. Tołwińska ◽  
A. Szadkowska
Keyword(s):  
Type 1 Diabetes ◽  
Preliminary Report ◽  
Early Atherosclerosis

Atherogenic vascular and lipid phenotypes in young patients with Type 1 diabetes are associated with diabetes high-risk HLA genotype

2007 ◽  
Vol 293 (5) ◽  
pp. H3175-H3179 ◽  
Author(s):  
Michal Odermarsky ◽  
Anita Nilsson ◽  
Åke Lernmark ◽  
Sture Sjöblad ◽  
Petru Liuba
Keyword(s):  
Endothelial Cells ◽  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Brachial Artery ◽  
Young Patients ◽  
Diabetes Duration ◽  
Analysis Of Covariance ◽  
Early Atherosclerosis ◽  
Hla Dq2

Expression of human leukocyte antigen (HLA) class II molecules on islet endothelial cells is a central vascular event in the pathogenesis of Type 1 diabetes. Previous studies demonstrated the ability of other vascular endothelial cells to express HLA and thereby to process islet autoantigens on their surface. We investigated whether the HLA-DQ2/8 genotype, which confers the highest risk for Type 1 diabetes, is associated with early atherosclerosis in youths with this disease. Brachial artery endothelium-dependent, flow-mediated dilation (BA-FMD) and carotid artery intima-media thickness (CA-IMT), as well as markers of systemic inflammation [C-reactive protein (CRP), fibrinogen, and orosomucoid], HbA1C, LDL, HDL, and total cholesterol, were assessed in 86 children and adolescents with Type 1 diabetes (mean age and diabetes duration, 15 and 7 yr, respectively) between 2004 and 2006. HLA genotypes were determined in dried blood spots by an oligoblot hybridization method. As a result, HLA-DQ2/8 was detected in 34 patients (DQ2/8). When this group was compared with the remaining patients (non-DQ2/8, n = 52), there were no differences in age, diabetes duration, HbA1C, body mass index, inflammatory markers, and IMT ( P ≥ 0.4). In the DQ2/8 group, LDL-to-HDL ratio was elevated compared with that in the non-DQ2/8 group (1.8 vs. 1.3, respectively; P = 0.001), whereas FMD did not significantly differ between the groups (5.3% vs. 6.7%, respectively; P = 0.08). When patients were further categorized in relation to CRP (cut-off value, 1 mg/l), BA-FMD was significantly lower (3%, P < 0.01), whereas LDL-to-HDL ratio increased further (2.2, P < 0.001) in the subgroup of DQ2/8 and CRP ≥ 1 patients compared with the remaining three subgroups. These associations remained significant after adjustment for age, diabetes duration, and HbA1C by analysis of covariance. The brachial artery responses to nitroglycerine were similar in all subgroups. In conclusion, the diabetes-predisposing HLA-DQ2/8 genotype in children and adolescents with Type 1 diabetes interferes with endothelial and lipid-related mechanisms of early atherosclerosis, possibly in part through inflammatory pathways.

Assessment of biomarkers of inflammation and premature atherosclerosis in adolescents with type-1 diabetes mellitus

2019 ◽  
Vol 32 (2) ◽  
pp. 109-113 ◽  
Author(s):  
Ghufran Babar ◽  
Mark Clements ◽  
Hongying Dai ◽  
Geetha Raghuveer
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Type 1 Diabetes Mellitus ◽  
Pearson Correlation ◽  
Premature Coronary Artery Disease ◽  
The Impact ◽  
Early Atherosclerosis

Abstract Background Type-1 diabetes mellitus (T1DM) causes endothelial dysfunction and early atherosclerosis, which can result in premature coronary artery disease. The aim of this study was to determine the impact of glycemic control, vascular oxidative stress and inflammation on vascular health in adolescents with T1DM. Methods This was a cross-sectional study in adolescents with age- and sex-matched T1DM who were ≥12 years and were at least 2 years post-diagnosis. Recruitment was balanced to include individuals with hemoglobin A1c (HbA1c) ≤8.5% (n=27) or with HbA1c ≥9.5% (n=25). Biomarkers of inflammation were measured in the blood including C-reactive protein (CRP), interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1), E-selectin, fibrinogen and tumor necrosis factor-α (TNF-α). Carotid intima media thickness (cIMT) and peripheral arterial tonometry (PAT) were assessed. Results Plasma E-selectin level was significantly different between the two groups with higher levels in the group with HbA1c ≥9.5% (65.0±27.7 ng/mL vs. 48.8±21.5 ng/mL, p=0.02). Though cIMT and PAT were not significantly different between the groups, Pearson correlation showed a significant direct relationship between rising HbA1c and mean right cIMT (p=0.02; r=0.37), PAT (p=0.03, r=0.31) and fibrinogen (p=0.03, r=0.03). Conclusions Elevated E-selectin level is an early marker of oxidative stress in T1DM patients with an elevated HbA1c level. Suboptimal glycemic control as evidenced by a rising HbA1c causes early atherosclerosis.

Early Microvascular Changes with Loss of the Glycocalyx in Children with Type 1 Diabetes

2014 ◽  
Vol 164 (3) ◽  
pp. 584-589.e1 ◽  
Author(s):  
Claudia Nussbaum ◽  
Ana Cavalcanti Fernandes Heringa ◽  
Zuzana Mormanova ◽  
Alexandra F. Puchwein-Schwepcke ◽  
Susanne Bechtold-Dalla Pozza ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Microvascular Changes

scholarly journals Noninvasive Magnetic Resonance Imaging of Microvascular Changes in Type 1 Diabetes

Diabetes ◽  
2007 ◽  
Vol 56 (11) ◽  
pp. 2677-2682 ◽  
Author(s):  
Z. Medarova ◽  
G. Castillo ◽  
G. Dai ◽  
E. Bolotin ◽  
A. Bogdanov ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Type 1 Diabetes ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Microvascular Changes
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