scholarly journals A longitudinal study of serum insulin-like growth factor-I levels over 6 years in a large cohort of children and adolescents with type 1 diabetes mellitus: A marker reflecting diabetic retinopathy

2018 ◽  
Vol 19 (5) ◽  
pp. 972-978 ◽  
Author(s):  
Daniel Öberg ◽  
Jenny Salemyr ◽  
Eva Örtqvist ◽  
Anders Juul ◽  
Peter Bang
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Longitudinal Study ◽  
Growth Factor ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Serum Insulin ◽  
Factor I

scholarly journals A Role of Free Insulin-Like Growth Factor-I in Dawn Phenomenon in Children and Adolescents with TYPE 1 Diabetes Mellitus

2000 ◽  
Vol 47 (SupplMarch) ◽  
pp. S91-S93 ◽  
Author(s):  
KISHO KOBAYASHI ◽  
KOJI KOBAYASHI ◽  
MIE MOCHIZUKI ◽  
KYOKO MATSUSHITA ◽  
EMI SAWANOBORI ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Growth Factor ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Free Insulin

Role of free insulin-like growth factor-I in hyperglycemia in patients with type 1 diabetes mellitus

2000 ◽  
Vol 50 ◽  
pp. 417
Author(s):  
Kisho Kobayashi ◽  
Shin Amemiya ◽  
Koji Kobayashi ◽  
Mie Mochizuki ◽  
Tomoaki Sano ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Growth Factor ◽  
Type 1 Diabetes Mellitus ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Free Insulin ◽  
Growth Factor I

scholarly journals Serum Concentrations of Transforming Growth Factor-Beta 1 in Predicting the Occurrence of Diabetic Retinopathy in Juvenile Patients with Type 1 Diabetes Mellitus

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Katarzyna Zorena ◽  
Ewa Malinowska ◽  
Dorota Raczyńska ◽  
Małgorzata Myśliwiec ◽  
Krystyna Raczyńska
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Growth Factor ◽  
Type 1 Diabetes Mellitus ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Serum Concentrations ◽  
Growth Factor Beta

In the present study, we have decided to evaluate if serum transforming growth factor-beta 1 (TGF-β1) concentrations may have diagnostic value in predicting the occurrence of diabetic retinopathy (DR) in juvenile patients with type 1 diabetes mellitus (T1DM). The study included 81 children and adolescents with T1DM and 19 control subjects. All study participants had biochemical parameters examined, underwent an eye examination, and 24-hour blood pressure monitoring. Moreover, serum concentrations of TGF-β1 were measured. The group of patients with T1DM and nonproliferative diabetic retinopathy (NPDR) had statistically significant higher serum levels of TGF-β1 (P=0.001) as compared to T1DM patients without retinopathy as well as the healthy control subject. The threshold serum TGF-β1 concentrations which had a discriminative ability to predict the presence of DR were calculated using the receiver operating characteristic (ROC) curves analysis and amounted to 443 pg/ml. The area under the ROC curve (AUCROC) was 0.80, and its population value was in the range of 0.66 to 0.94. The sensitivity and specificity were calculated to be 72% and 88%, respectively. Our results suggest that TGF-β1 serum concentrations may be an additional parameter in predicting the occurrence of DR in juvenile patients with T1DM.

Sexual dimorphism in growth and insulin-like growth factor-I in children with type 1 diabetes mellitus

2014 ◽  
Vol 24 (6) ◽  
pp. 256-259 ◽  
Author(s):  
Carla Bizzarri ◽  
Danila Benevento ◽  
Germana Giannone ◽  
Marzia Bongiovanni ◽  
Marco Anziano ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Sexual Dimorphism ◽  
Growth Factor ◽  
Type 1 Diabetes Mellitus ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I
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