Brain injury markers: S100 calcium-binding protein B, neuron-specific enolase and glial fibrillary acidic protein in children with diabetic ketoacidosis

2018 ◽  
Vol 19 (5) ◽  
pp. 1000-1006
Author(s):  
Gönül Çatlı ◽  
Ahmet Anık ◽  
Sezer Acar ◽  
Tuncay Küme ◽  
Melike Karabulut ◽  
...  
Keyword(s):  
Brain Injury ◽  
Glial Fibrillary Acidic Protein ◽  
Diabetic Ketoacidosis ◽  
Calcium Binding ◽  
Binding Protein ◽  
Neuron Specific Enolase ◽  
Calcium Binding Protein ◽  
Acidic Protein ◽  
S100 Calcium Binding Protein ◽  
Protein B

scholarly journals Aberrant Development of Enteric Glial Cells in the Colon of Hirschsprung's Disease

2021 ◽  
Vol 9 ◽  
Author(s):  
Tingting Zhou ◽  
Wei Liu ◽  
Xiaofang Yu ◽  
Zengcai Cao ◽  
Weijing Mu ◽  
...  
Keyword(s):  
Glial Fibrillary Acidic Protein ◽  
Glial Cells ◽  
Calcium Binding ◽  
Hirschsprung's Disease ◽  
Binding Protein ◽  
Calcium Binding Protein ◽  
Acidic Protein ◽  
S100 Calcium Binding Protein ◽  
Enteric Glial Cells ◽  
Protein B

Objective: The aim of this study was to explore the development of enteric glial cells (EGCs) in different segments of Hirschsprung's disease (HSCR).Methods: Colonic specimens from 35 children with HSCR were selected to analyze the relative expression of glial fibrillary acidic protein and S100 calcium-binding protein B using Western blotting and real-time fluorescence quantitative PCR. Immunofluorescence and immunohistochemical staining were performed to determine the distribution of myenteric EGCs and neuronal cells in different segments of HSCR.Results: There was a trend of diminished protein and mRNA expression of glial fibrillary acidic protein and S100 calcium-binding protein B from the proximal, dilated, and transitional segments to the aganglionic segment (p < 0.05). Immunofluorescence and immunohistochemistry showed that the EGCs in the aganglionic, transitional, and dilated colonic muscles were morphologically abnormal, which was consistent with the dysplasia of myenteric neurons.Conclusion: Aberrant development of myenteric EGCs was observed in the colon of HSCR, which may affect the survival of enteric neurons.

scholarly journals Serum Neuron-specific Enolase and S100 Calcium-binding Protein B in Pediatric Diabetic Ketoacidosis

2019 ◽  
Vol 11 (4) ◽  
pp. 374-387 ◽  
Author(s):  
Hatem Hamed Elshorbagy ◽  
Naglaa Fathy Barseem ◽  
Akram Elshafey Elsadek ◽  
Ashraf Hamed Al-shokary ◽  
Yehia Hamed Abdel Maksoud ◽  
...  
Keyword(s):  
Diabetic Ketoacidosis ◽  
Calcium Binding ◽  
Binding Protein ◽  
Neuron Specific Enolase ◽  
Calcium Binding Protein ◽  
S100 Calcium Binding Protein ◽  
Serum Neuron Specific Enolase ◽  
Protein B

scholarly journals Serum neuron-specific enolase and S100 calcium binding protein B biomarker levels do not improve diagnosis of acute stroke

2012 ◽  
Vol 42 (3) ◽  
pp. 199-204 ◽  
Author(s):  
S González-García ◽  
A González-Quevedo ◽  
M Peña-Sánchez ◽  
C Menéndez-Saínz ◽  
R Fernández-Carriera ◽  
...  
Keyword(s):  
Acute Stroke ◽  
Calcium Binding ◽  
Binding Protein ◽  
Neuron Specific Enolase ◽  
Calcium Binding Protein ◽  
S100 Calcium Binding Protein ◽  
Serum Neuron Specific Enolase ◽  
Protein B

Effects of Foot-Strike Patterns on Biomarkers S100 Calcium-Binding Protein B/Neuron-Specific Enolase in Running—A Pilot Study

2020 ◽  
Vol 15 (6) ◽  
pp. 900-902
Author(s):  
Jan Schroeder ◽  
Franziska Erthel ◽  
Karsten Hollander
Keyword(s):  
Calcium Binding ◽  
Binding Protein ◽  
Neuron Specific Enolase ◽  
Calcium Binding Protein ◽  
Significant Interaction Effect ◽  
Impact Forces ◽  
S100 Calcium Binding Protein ◽  
Foot Strike ◽  
Recreational Runners ◽  
Protein B

Purpose: Foot-strike patterns (FSP) in running are related to certain impact kinetics during ground contact. A rear-foot strike (RFS) has been associated with higher impact forces, whereas a forefoot strike (FFS) is assumed to minimize these impact forces. This study investigated the effects of running with RFS or FFS on impact-sensitive neuronal biomarkers S100 calcium-binding protein B (S100B), neuron-specific enolase (NSE), and lactate dehydrogenase (LDH). Methods: In this randomized crossover study, 18 healthy recreational runners (14 male, mean [SD] age 28.2 [4.7] y, body mass index 22.8 [1.9]) ran 2 separate 5-mile runs with RFS or FFS, respectively. Blood samples were taken before (pre), 30 min after (post 0), and 24 h after (post 24) the run. S100B, NSE, and LDH concentrations were determined and analyzed (3 × 2 data model). Results: S100B, NSE, and LDH concentrations increased from pre to post 0 and decreased within 24 h back to the baseline level, demonstrating a significant time effect (all P < .01, all ). No main effect for FSP or any significant interaction effect indicating FSP-specific differences between FFS or RFS was found (all P > .05, all ), except for LDH (P < .001, ). Conclusions: NSE, S100B, and LDH concentration increased in the short term after running and returned to normal in 24 h. FSP with varying impact forces does not influence the increase of these biomarkers. LDH findings favor peripheral origins, but mixed effects are possible. Thus, further research is needed to estimate the risk of mild traumatic encephalopathy.

scholarly journals Acute Sleep Deprivation Increases Serum Levels of Neuron-Specific Enolase (NSE) and S100 Calcium Binding Protein B (S-100B) in Healthy Young Men

SLEEP ◽  
2014 ◽  
Vol 37 (1) ◽  
pp. 195-198 ◽  
Author(s):  
Christian Benedict ◽  
Jonathan Cedernaes ◽  
Vilmantas Giedraitis ◽  
Emil K. Nilsson ◽  
Pleunie S. Hogenkamp ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Calcium Binding ◽  
Binding Protein ◽  
Neuron Specific Enolase ◽  
Young Men ◽  
Serum Levels ◽  
Calcium Binding Protein ◽  
S100 Calcium Binding Protein ◽  
Acute Sleep Deprivation ◽  
Protein B
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