Interleukin-7 receptor α-chain haplotypes differentially affect soluble IL-7 receptor and IL-7 serum concentrations in children with type 1 diabetes

2018 ◽  
Vol 19 (5) ◽  
pp. 955-962 ◽  
Author(s):  
Julia Seyfarth ◽  
Christian Lundtoft ◽  
Katharina Förtsch ◽  
Heinz Ahlert ◽  
Joachim Rosenbauer ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Serum Concentrations ◽  
Interleukin 7 ◽  
Α Chain

scholarly journals Assessment of Serum Concentrations of Adropin, Afamin, and Neudesin in Children with Type 1 Diabetes

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Agnieszka Polkowska ◽  
Izabela Elżbieta Pasierowska ◽  
Marta Pasławska ◽  
Elżbieta Pawluczuk ◽  
Artur Bossowski
Keyword(s):  
Type 1 Diabetes ◽  
Glucose Metabolism ◽  
Statistical Significance ◽  
Serum Levels ◽  
Control Group ◽  
Diabetic Patients ◽  
Serum Concentrations ◽  
Novel Biomarkers ◽  
Varied Duration

Introduction. The increasing knowledge of adropin, afamin, and neudesin and the regulation of glucose metabolism and insulin resistance allows for the assessment of the differences in their concentrations between the groups with varied duration of diabetes mellitus (DM). Aim of the Study. Assessment of serum levels of adropin, afamin, and neudesin in children with type 1 diabetes, with respect to the disease duration. Materials and Methods. The study consisted of 138 patients aged 5–18 years (M 40.58%). Children with type 1 diabetes (n = 68) were compared to the control group (n = 70). The diabetic group was divided into 4 subgroups: (I) newly diagnosed patients, after an episode of ketoacidosis (n = 14), (II) duration no longer than 5 years (n = 18), (III) 5 to 10 years (n = 27), and (IV) longer than 10 years (n = 9). Serum concentrations of adropin, afamin, and neudesin were assessed and compared between the groups of patients. The criterion for statistical significance was p<0.05. Results. The concentrations of adropin and afamin across all subgroups were lower than that in the control group, while neudesin levels were higher in diabetic patients compared to the control group. The differences were statistically significant. Conclusions. Adropin, afamin, and neudesin may play a major role in the regulation of glucose metabolism and have a significant potential as novel biomarkers to predict future metabolic disorders. However, further multicentre studies on a larger cohort of patients are necessary to specify the role of these substances in the course and treatment of type 1 diabetes.

scholarly journals Increased Resistin Serum Concentrations in Patients with Type 1 Diabetes Mellitus

2013 ◽  
Vol 5 (3) ◽  
pp. 189-193 ◽  
Author(s):  
Geyikli İclal ◽  
Keskin Mehmet ◽  
Kör Yılmaz ◽  
Akan Müslüm
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Serum Concentrations

scholarly journals Tissue Polypeptide-Specific Antigen Serum Concentrations in Children, Adolescents, and Young Adults With Type 1 Diabetes

Diabetes Care ◽  
2002 ◽  
Vol 25 (1) ◽  
pp. 240-241 ◽  
Author(s):  
A. Malamitsi-Puchner ◽  
A. Vazeou-Gerasimidi ◽  
A. Sarandakou ◽  
J. Tziotis ◽  
P. Trikka ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Young Adults ◽  
Specific Antigen ◽  
Adolescents And Young Adults ◽  
Serum Concentrations

scholarly journals Serum Concentrations of Transforming Growth Factor-Beta 1 in Predicting the Occurrence of Diabetic Retinopathy in Juvenile Patients with Type 1 Diabetes Mellitus

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Katarzyna Zorena ◽  
Ewa Malinowska ◽  
Dorota Raczyńska ◽  
Małgorzata Myśliwiec ◽  
Krystyna Raczyńska
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Growth Factor ◽  
Type 1 Diabetes Mellitus ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Serum Concentrations ◽  
Growth Factor Beta

In the present study, we have decided to evaluate if serum transforming growth factor-beta 1 (TGF-β1) concentrations may have diagnostic value in predicting the occurrence of diabetic retinopathy (DR) in juvenile patients with type 1 diabetes mellitus (T1DM). The study included 81 children and adolescents with T1DM and 19 control subjects. All study participants had biochemical parameters examined, underwent an eye examination, and 24-hour blood pressure monitoring. Moreover, serum concentrations of TGF-β1 were measured. The group of patients with T1DM and nonproliferative diabetic retinopathy (NPDR) had statistically significant higher serum levels of TGF-β1 (P=0.001) as compared to T1DM patients without retinopathy as well as the healthy control subject. The threshold serum TGF-β1 concentrations which had a discriminative ability to predict the presence of DR were calculated using the receiver operating characteristic (ROC) curves analysis and amounted to 443 pg/ml. The area under the ROC curve (AUCROC) was 0.80, and its population value was in the range of 0.66 to 0.94. The sensitivity and specificity were calculated to be 72% and 88%, respectively. Our results suggest that TGF-β1 serum concentrations may be an additional parameter in predicting the occurrence of DR in juvenile patients with T1DM.

scholarly journals Serum concentrations of selected chemokines (CXCL1/GROα and CXCL8/IL8) in patients with type 1 diabetes

2014 ◽  
Vol 13 (1) ◽  
pp. 9-16
Author(s):  
Katarzyna Zorena ◽  
◽  
Olga Jachimowicz-Duda ◽  
Dorota Raczyńska ◽  
◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Serum Concentrations

Interleukin-7 and Type 1 Diabetes

2014 ◽  
Vol 14 (9) ◽  
Author(s):  
Paolo Monti ◽  
Ezio Bonifacio
Keyword(s):  
Type 1 Diabetes ◽  
Interleukin 7

scholarly journals Concentration and Activity of the Soluble Form of the Interleukin-7 Receptor   in Type 1 Diabetes Identifies an Interplay Between Hyperglycemia and Immune Function

Diabetes ◽  
2013 ◽  
Vol 62 (7) ◽  
pp. 2500-2508 ◽  
Author(s):  
P. Monti ◽  
C. Brigatti ◽  
M. Krasmann ◽  
A. G. Ziegler ◽  
E. Bonifacio
Keyword(s):  
Type 1 Diabetes ◽  
Immune Function ◽  
Soluble Form ◽  
Interleukin 7
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