Beta cell function after intensive subcutaneous insulin therapy or intravenous insulin infusion at onset of type 1 diabetes in children without ketoacidosis

2018 ◽  
Vol 19 (6) ◽  
pp. 1079-1085 ◽  
Author(s):  
Rebecka Enander ◽  
Peter Adolfsson ◽  
Torun Bergdahl ◽  
Gun Forsander ◽  
Johnny Ludvigsson ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Beta Cell ◽  
Insulin Therapy ◽  
Beta Cell Function ◽  
Insulin Infusion ◽  
Cell Function ◽  
Subcutaneous Insulin ◽  
Intravenous Insulin

294-OR: Type 1 Diabetes Patients with Residual Beta-Cell Function Display Improved Time in Euglycemia and Less Glycaemic Fluctuation after Exercise

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 294-OR
Author(s):  
GUY S. TAYLOR ◽  
KIERAN SMITH ◽  
JADINE SCRAGG ◽  
AYAT BASHIR ◽  
RICHARD A. ORAM ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Diabetes Patients

scholarly journals Autoantigen Treatment in Type 1 Diabetes: Unsolved Questions on How to Select Autoantigen and Administration Route

2020 ◽  
Vol 21 (5) ◽  
pp. 1598 ◽  
Author(s):  
Johnny Ludvigsson
Keyword(s):  
Type 1 Diabetes ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Human Subjects ◽  
Subcutaneous Administration ◽  
Acid Decarboxylase ◽  
Recent Onset ◽  
Prevention Trials

Autoantigen treatment has been tried for the prevention of type 1 diabetes (T1D) and to preserve residual beta-cell function in patients with a recent onset of the disease. In experimental animal models, efficacy was good, but was insufficient in human subjects. Besides the possible minor efficacy of peroral insulin in high-risk individuals to prevent T1D, autoantigen prevention trials have failed. Other studies on autoantigen prevention and intervention at diagnosis are ongoing. One problem is to select autoantigen/s; others are dose and route. Oral administration may be improved by using different vehicles. Proinsulin peptide therapy in patients with T1D has shown possible minor efficacy. In patients with newly diagnosed T1D, subcutaneous injection of glutamic acid decarboxylase (GAD) bound to alum hydroxide (GAD-alum) can likely preserve beta-cell function, but the therapeutic effect needs to be improved. Intra-lymphatic administration may be a better alternative than subcutaneous administration, and combination therapy might improve efficacy. This review elucidates some actual problems of autoantigen therapy in the prevention and/or early intervention of type 1 diabetes.

scholarly journals Stability of disease-associated antibody titers in pregnant women with type 1 diabetes with or without residual beta-cell function

Diabetes Care ◽  
2000 ◽  
Vol 23 (7) ◽  
pp. 1019-1021 ◽  
Author(s):  
E. J. Novak ◽  
E. Ortqvist ◽  
E. Nord ◽  
L. Edwall ◽  
C. S. Hampe ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Beta Cell ◽  
Pregnant Women ◽  
Beta Cell Function ◽  
Cell Function ◽  
Antibody Titers
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