Expression of CD4+CD28nullT lymphocytes in children and adolescents with type 1 diabetes mellitus: Relation to microvascular complications, aortic elastic properties, and carotid intima media thickness

2017 ◽  
Vol 18 (8) ◽  
pp. 785-793 ◽  
Author(s):  
Mona H. El-Samahy ◽  
Azza A. G. Tantawy ◽  
Amira A. M. Adly ◽  
Nevin M. Habeeb ◽  
Eman A. R. Ismail ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Elastic Properties ◽  
Microvascular Complications ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Aortic Elastic Properties

Carotid intima media thickness and associations with serum osteoprotegerin and s-RANKL in children and adolescents with type 1 diabetes mellitus with increased risk for endothelial dysfunction

2018 ◽  
Vol 0 (0) ◽  
Author(s):  
Kyriaki Karavanaki ◽  
Emmanouil Tsouvalas ◽  
Marina Vakaki ◽  
Alexandra Soldatou ◽  
Charalambos Tsentidis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Endothelial Dysfunction ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Negatively Associated ◽  
Increased Risk

Abstract Background Although carotid intima media thickness (CIMT) is an established marker of endothelial dysfunction, limited data exist on relative laboratory biomarkers in youngsters with type 1 diabetes mellitus (T1DM). Our aim was to study CIMT and the biomarkers of the osteoprotegerin (OPG)/RANKL system in young T1DM patients and controls, and also in subgroups of patients with increased risk for endothelial dysfunction, such as those with overweight/obesity, poor metabolic control or the presence of microalbuminuria. Methods CIMT and OPG/RANKL of 56 T1DM children and adolescents were compared to 28 healthy controls. Results Anthropometric, laboratory, CIMT and OPG/RANKL measurements were similar between patients and controls. Overweight/obese patients had greater CIMT than the normal weight ones (0.50 vs. 0.44 mm, p=0.001). Microalbuminuric patients had greater CIMT (0.49 vs. 0.44 mm, p=0.035) than the normoalbuminuric ones, with no difference in terms of OPG/RANKL. In the microalbuminuric group, OPG (r=−0.90, p=0.036) and RANKL (r=−0.92, p=0.024) were significantly negatively associated with CIMT. Following linear regression analysis, in the total patients group, microalbuminuria was the only factor significantly associated with CIMT (beta±SE: 0.050±0.021, p=0.035), body mass index (BMI)-z-scores were negatively associated with OPG (beta±SE: −0.25±0.12, p=0.05), while in the microalbuminuric group, CIMT was negatively associated with OPG (beta±SE: −0.070±0.019, p=0.036). During the forward stepwise procedure, microalbuminuria and age were the only variables negatively associated with RANKL (b=−0.334, p=0.034, b=−35.95, p=0.013, respectively). Conclusions In T1DM pediatric patients, overweight/obesity and microalbuminuria were associated with greater CIMT and with impaired OPG/RANKL levels, as biochemical indices of calcification of the atherosclerotic plaque.

Gender, metabolic control and carotid intima-media-thickness in children and adolescents with type 1 diabetes mellitus

2014 ◽  
Vol 127 (3-4) ◽  
pp. 116-123 ◽  
Author(s):  
Georgiana-Aura Giurgea ◽  
Katrin Nagl ◽  
Michael Gschwandtner ◽  
Clemens Höbaus ◽  
Thomas Hörtenhuber ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Metabolic Control ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness

scholarly journals IMPACT OF HEMODIALYSIS AND SUBSEQUENT SIMULTANEOUS KIDNEY-PANCREAS TRANSPLANT ON CAROTID INTIMA-MEDIA THICKNESS IN TYPE 1 DIABETES MELLITUS PATIENTS

2012 ◽  
Vol 59 (13) ◽  
pp. E1672
Author(s):  
Valter C. Lima ◽  
João Miguel M. Dantas ◽  
Claudia Maria Alves ◽  
Rodrigo Fernandes A. Neves ◽  
Claudio S. Melaragno ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Pancreas Transplant ◽  
Media Thickness

scholarly journals Predictors of subclinical atherosclerosis evaluated by carotid intima-media thickness in asymptomatic young women with type 1 diabetes mellitus

2017 ◽  
Vol 61 (2) ◽  
pp. 115-121 ◽  
Author(s):  
Rosane Kupfer ◽  
Manuella Rangel Larrúbia ◽  
Isabela Bussade ◽  
Joana Rodrigues Dantas Pereira ◽  
Giovanna A. Balarini Lima ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Young Women ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness
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