Pharmacokinetic and prandial pharmacodynamic properties of insulin degludec/insulin aspart in children, adolescents, and adults with type 1 diabetes

Torben Biester; Thomas Danne; Sarah Bläsig; Kerstin Remus; Bärbel Aschemeier; Olga Kordonouri; Lars Bardtrum; Hanne Haahr

doi:10.1111/pedi.12358

Pharmacokinetic and prandial pharmacodynamic properties of insulin degludec/insulin aspart in children, adolescents, and adults with type 1 diabetes

Pediatric Diabetes ◽

10.1111/pedi.12358 ◽

2016 ◽

Vol 17 (8) ◽

pp. 642-649 ◽

Cited By ~ 10

Author(s):

Torben Biester ◽

Thomas Danne ◽

Sarah Bläsig ◽

Kerstin Remus ◽

Bärbel Aschemeier ◽

...

Keyword(s):

Type 1 Diabetes ◽

Insulin Aspart ◽

Insulin Degludec ◽

Adolescents And Adults

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Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus Type 1): a phase 3, randomised, open-label, treat-to-target non-inferiority trial

The Lancet ◽

10.1016/s0140-6736(12)60204-9 ◽

2012 ◽

Vol 379 (9825) ◽

pp. 1489-1497 ◽

Cited By ~ 221

Author(s):

Simon Heller ◽

John Buse ◽

Miles Fisher ◽

Satish Garg ◽

Michel Marre ◽

...

Keyword(s):

Type 1 Diabetes ◽

Insulin Glargine ◽

Insulin Aspart ◽

Insulin Degludec ◽

Treat To Target ◽

Open Label ◽

Phase 3 ◽

Mealtime Insulin ◽

Basal Bolus

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Efficacy and safety of a fixed combination of insulin degludec/insulin aspart in children and adolescents with type 1 diabetes: A randomized trial

Pediatric Diabetes ◽

10.1111/pedi.12724 ◽

2018 ◽

Vol 19 (7) ◽

pp. 1263-1270 ◽

Cited By ~ 2

Author(s):

Tadej Battelino ◽

Larry C. Deeb ◽

Magnus Ekelund ◽

Ona Kinduryte ◽

Georgeanna J. Klingensmith ◽

...

Keyword(s):

Type 1 Diabetes ◽

Randomized Trial ◽

Children And Adolescents ◽

Insulin Aspart ◽

Fixed Combination ◽

Insulin Degludec ◽

Efficacy And Safety

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Insulin degludec/insulin aspart in Japanese patients with type 1 diabetes mellitus: Distinct prandial and basal glucose‐lowering effects

Journal of Diabetes Investigation ◽

10.1111/jdi.12461 ◽

2016 ◽

Vol 7 (4) ◽

pp. 574-580 ◽

Cited By ~ 6

Author(s):

Hanne Haahr ◽

Tomio Sasaki ◽

Lars Bardtrum ◽

Ippei Ikushima

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Insulin Aspart ◽

Japanese Patients ◽

Insulin Degludec ◽

Glucose Lowering

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Safety and efficacy of insulin degludec/insulin aspart with bolus mealtime insulin aspart compared with standard basal-bolus treatment in people with Type 1 diabetes: 1-year results from a randomized clinical trial (BOOST® T1)

Diabetic Medicine ◽

10.1111/dme.13068 ◽

2016 ◽

Vol 34 (2) ◽

pp. 167-173 ◽

Cited By ~ 16

Author(s):

I. B. Hirsch ◽

E. Franek ◽

H. Mersebach ◽

L. Bardtrum ◽

K. Hermansen

Keyword(s):

Clinical Trial ◽

Type 1 Diabetes ◽

Randomized Clinical Trial ◽

Insulin Aspart ◽

Insulin Degludec ◽

Safety And Efficacy ◽

Mealtime Insulin ◽

Basal Bolus

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Insulin Degludec/Insulin Aspart Administered Once Daily at Any Meal, With Insulin Aspart at Other Meals Versus a Standard Basal-Bolus Regimen in Patients With Type 1 Diabetes: A 26-week, phase 3, randomized, open-label, treat-to-target trial

Diabetes Care ◽

10.2337/dc11-2503 ◽

2012 ◽

Vol 35 (11) ◽

pp. 2174-2181 ◽

Cited By ~ 49

Author(s):

I. B. Hirsch ◽

B. Bode ◽

J.-P. Courreges ◽

P. Dykiel ◽

E. Franek ◽

...

Keyword(s):

Type 1 Diabetes ◽

Insulin Aspart ◽

Insulin Degludec ◽

Treat To Target ◽

Target Trial ◽

Open Label ◽

Phase 3 ◽

Once Daily ◽

Basal Bolus

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Efficacy and safety of insulin degludec given as part of basal–bolus treatment with mealtime insulin aspart in type 1 diabetes: a 26‐week randomized, open‐label, treat‐to‐target non‐inferiority trial

Diabetes Obesity and Metabolism ◽

10.1111/dom.12298 ◽

2014 ◽

Vol 16 (10) ◽

pp. 922-930 ◽

Cited By ~ 29

Author(s):

M. J. Davies ◽

J. L. Gross ◽

Y. Ono ◽

T. Sasaki ◽

G. Bantwal ◽

...

Keyword(s):

Type 1 Diabetes ◽

Insulin Aspart ◽

Insulin Degludec ◽

Treat To Target ◽

Efficacy And Safety ◽

Open Label ◽

Mealtime Insulin ◽

Basal Bolus

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Insulin degludec improves glycaemic control with lower nocturnal hypoglycaemia risk than insulin glargine in basal–bolus treatment with mealtime insulin aspart in Type 1 diabetes (BEGIN ® Basal–Bolus Type 1): 2‐year results of a randomized clinical trial

Diabetic Medicine ◽

10.1111/dme.12243 ◽

2013 ◽

Vol 30 (11) ◽

pp. 1293-1297 ◽

Cited By ~ 65

Author(s):

B. W. Bode ◽

J. B. Buse ◽

M. Fisher ◽

S. K. Garg ◽

M. Marre ◽

...

Keyword(s):

Clinical Trial ◽

Type 1 Diabetes ◽

Glycaemic Control ◽

Insulin Glargine ◽

Insulin Aspart ◽

Insulin Degludec ◽

Nocturnal Hypoglycaemia ◽

Mealtime Insulin ◽

Basal Bolus

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Distinct Prandial and Basal Glucose-Lowering Effects of Insulin Degludec/Insulin Aspart (IDegAsp) at Steady State in Subjects with Type 1 Diabetes Mellitus

Diabetes Therapy ◽

10.1007/s13300-014-0070-2 ◽

2014 ◽

Vol 5 (1) ◽

pp. 255-265 ◽

Cited By ~ 41

Author(s):

Tim Heise ◽

Leszek Nosek ◽

Carsten Roepstorff ◽

Suresh Chenji ◽

Oliver Klein ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Steady State ◽

Type 1 Diabetes Mellitus ◽

Insulin Aspart ◽

Insulin Degludec ◽

Glucose Lowering

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Insulin degludec in combination with bolus insulin aspart is safe and effective in children and adolescents with type 1 diabetes

Pediatric Diabetes ◽

10.1111/pedi.12263 ◽

2015 ◽

Vol 16 (3) ◽

pp. 164-176 ◽

Cited By ~ 40

Author(s):

Nandu Thalange ◽

Larry Deeb ◽

Violeta Iotova ◽

Tomoyuki Kawamura ◽

Georgeanna Klingensmith ◽

...

Keyword(s):

Type 1 Diabetes ◽

Children And Adolescents ◽

Insulin Aspart ◽

Insulin Degludec ◽

Bolus Insulin

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Insulin degludec/insulin aspart produces a dose-proportional glucose-lowering effect in subjects with type 1 diabetes mellitus

Diabetes Obesity and Metabolism ◽

10.1111/dom.12463 ◽

2015 ◽

Vol 17 (7) ◽

pp. 659-664 ◽

Cited By ~ 15

Author(s):

T. Heise ◽

L. Nosek ◽

O. Klein ◽

H. Coester ◽

A. L. Svendsen ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Insulin Aspart ◽

Insulin Degludec ◽

Glucose Lowering ◽

Lowering Effect ◽

Glucose Lowering Effect ◽

Dose Proportional

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