Triglyceride glucose index as a surrogate measure of insulin sensitivity in obese adolescents with normoglycemia, prediabetes, and type 2 diabetes mellitus: comparison with the hyperinsulinemic-euglycemic clamp

2015 ◽  
Vol 17 (6) ◽  
pp. 458-465 ◽  
Author(s):  
Noor Shafina Mohd Nor ◽  
SoJung Lee ◽  
Fida Bacha ◽  
Hala Tfayli ◽  
Silva Arslanian
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Sensitivity ◽  
Obese Adolescents ◽  
Euglycemic Clamp ◽  
Hyperinsulinemic Euglycemic Clamp ◽  
Triglyceride Glucose Index ◽  
Surrogate Measure

scholarly journals Liraglutide, a Glucagon-Like Peptide-1 Analog, Increased Insulin Sensitivity Assessed by Hyperinsulinemic-Euglycemic Clamp Examination in Patients with Uncontrolled Type 2 Diabetes Mellitus

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Hideaki Jinnouchi ◽  
Seigo Sugiyama ◽  
Akira Yoshida ◽  
Kunio Hieshima ◽  
Noboru Kurinami ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Insulin Sensitivity ◽  
Insulin Therapy ◽  
Euglycemic Clamp ◽  
Type 2 Dm ◽  
Hyperinsulinemic Euglycemic Clamp ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Aims. Glucagon-like peptide-1 (GLP-1) analog promotes insulin secretion by acting on pancreaticβ-cells. This antihyperglycemic treatment for type 2 diabetes mellitus (DM) has attracted increased clinical attention not only for its antihyperglycemic action but also for its potential extrapancreatic effects. We investigated whether liraglutide, a GLP-1 analog, could enhance insulin sensitivity as assessed by the hyperinsulinemic-euglycemic clamp in type 2 DM patients.Materials. We prospectively enrolled 31 uncontrolled type 2 DM patients who were hospitalized and equally managed by guided diet- and exercise-therapies and then introduced to either liraglutide- or intensive insulin-therapy for 4 weeks. Insulin sensitivity was assessed by the glucose infusion rate (GIR) using hyperinsulinemic-euglycemic clamp before and after the therapies.Results. Values of HbA1c, postprandial plasma glucose, and body mass index (BMI) were significantly decreased by hospitalized intensive insulin-therapy or liraglutide-therapy. GIR was significantly increased by liraglutide-therapy but not by insulin-therapy, indicating that liraglutide-therapy significantly enhanced insulin sensitivity. BMI decreased during liraglutide-therapy but was not significantly correlated with changes in GIR. Multivariate logistic regression analysis demonstrated that liraglutide-therapy significantly correlated with increased insulin sensitivity in uncontrolled DM patients.Conclusions. Liraglutide may exhibit favorable effects on diabetes control for type 2 DM patients by increasing insulin sensitivity as an extrapancreatic action. Clinical trial registration Unique Identifier isUMIN000015201.

Rosiglitazone improves insulin sensitivity with increased serum leptin levels in patients with type 2 diabetes mellitus

2008 ◽  
Vol 81 (1) ◽  
pp. 42-49 ◽  
Author(s):  
Hae Jin Kim ◽  
Soo Kyung Kim ◽  
Wan Sub Shim ◽  
Jae Hyuk Lee ◽  
Kyu Yeon Hur ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Sensitivity ◽  
Serum Leptin

Effects of rosiglitazone on body fat distribution and insulin sensitivity in Korean type 2 diabetes mellitus patients

Metabolism ◽  
2008 ◽  
Vol 57 (4) ◽  
pp. 479-487 ◽  
Author(s):  
You-Cheol Hwang ◽  
Eun Young Lee ◽  
Won Jae Lee ◽  
Bong Soo Cha ◽  
Kun-Ho Yoon ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Sensitivity ◽  
Body Fat ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Korean Type

scholarly journals Impaired peripheral insulin sensitivity in non-obese Japanese patients with type 2 diabetes mellitus and fatty liver

2017 ◽  
Vol 9 (3) ◽  
pp. 529-535 ◽  
Author(s):  
Yasuhiko Furukawa ◽  
Yoshifumi Tamura ◽  
Kageumi Takeno ◽  
Takashi Funayama ◽  
Hideyoshi Kaga ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Sensitivity ◽  
Fatty Liver ◽  
Japanese Patients ◽  
Peripheral Insulin Sensitivity
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