Cardiovascular medication use and cardiovascular disease in children and adolescents with type 1 diabetes: a population-based cohort study

2015 ◽  
Vol 17 (6) ◽  
pp. 433-440 ◽  
Author(s):  
Fariba Ahmadizar ◽  
Soulmaz Fazeli Farsani ◽  
Patrick C Souverein ◽  
Marja MJ van der Vorst ◽  
Anthonius de Boer ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Cohort Study ◽  
Children And Adolescents ◽  
Medication Use ◽  
Population Based ◽  
Cardiovascular Medication

scholarly journals Population-Based Cohort Study of Anti-Infective Medication Use before and after the Onset of Type 1 Diabetes in Children and Adolescents

2014 ◽  
Vol 58 (8) ◽  
pp. 4666-4674 ◽  
Author(s):  
Soulmaz Fazeli Farsani ◽  
Patrick C. Souverein ◽  
Marja M. J. van der Vorst ◽  
Catherijne A. J. Knibbe ◽  
Anthonius de Boer ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cohort Study ◽  
Children And Adolescents ◽  
Reference Group ◽  
Medication Use ◽  
Population Based ◽  
Second Line ◽  
Before And After ◽  
Reference Cohort

ABSTRACTA population-based cohort study was conducted in the Dutch PHARMO database to investigate prevalence and patterns of anti-infective medication use in children and adolescents with type 1 diabetes (T1D) before and after the onset of this disease. All patients <19 years with at least 2 insulin prescriptions (1999 to 2009) were identified (T1D cohort) and compared with an age- and sex-matched (ratio: 1 up to 4) diabetes-free reference group. The prevalence and average number of anti-infective use was studied from (up to) 8 years before until a maximum of 4 years after the onset of T1D. A total of 925 patients with T1D and 3,591 children and adolescents in the reference cohort (51% boys, mean age of 10.1 [standard deviation, 4.5] years) were included. The overall prevalence of anti-infective use (62.6 compared to 52.6%,P< 0.001) and average number of prescriptions (2.71 compared to 1.42 per child,P< 0.001) in the T1D cohort were significantly higher than those in the reference cohort after the onset of diabetes. This pattern was consistent across sex and age categories and already observed in the year before the onset of type 1 diabetes. Patients in the T1D cohort received more antibacterials (49.8 compared to 40%,P< 0.001), antimycotics (4.0 compared to 1.3%,P< 0.001), antivirals (2.5 compared to 0.4%,P< 0.001), and second-line antibiotics, such as aminoglycosides, quinolones, and third-generation cephalosporins and carbapenems. Our findings that elevated anti-infective use in the T1D cohort exists in the period before the onset of type 1 diabetes and the consumption of more second-line anti-infective compounds in this time period warrant further research.

scholarly journals Psychiatric medication use before and after the onset of type 1 diabetes in children and adolescents: A population-based cohort study

2017 ◽  
Vol 19 (1) ◽  
pp. 121-128 ◽  
Author(s):  
Soulmaz Fazeli Farsani ◽  
Heshu Abdullah-Koolmees ◽  
Patrick C Souverein ◽  
Anthonius de Boer ◽  
Aukje K Mantel-Teeuwisse
Keyword(s):  
Type 1 Diabetes ◽  
Cohort Study ◽  
Children And Adolescents ◽  
Medication Use ◽  
Population Based ◽  
Psychiatric Medication ◽  
Before And After

scholarly journals Risks of Psychiatric Disorders and Suicide Attempts in Children and Adolescents With Type 1 Diabetes: A Population-Based Cohort Study

Diabetes Care ◽  
2015 ◽  
Vol 38 (3) ◽  
pp. 453-459 ◽  
Author(s):  
Agnieszka Butwicka ◽  
Louise Frisén ◽  
Catarina Almqvist ◽  
Björn Zethelius ◽  
Paul Lichtenstein
Keyword(s):  
Type 1 Diabetes ◽  
Cohort Study ◽  
Children And Adolescents ◽  
Psychiatric Disorders ◽  
Suicide Attempts ◽  
Population Based

927-P: Risk of Substance Use Disorders among Adolescents and Emerging Adults with Type 1 Diabetes: A Population-Based Cohort Study

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 927-P
Author(s):  
ANA CREO ◽  
SWETHA SRIRAM ◽  
LISA VAUGHAN ◽  
AMY WEAVER ◽  
SEEMA KUMAR
Keyword(s):  
Substance Use ◽  
Type 1 Diabetes ◽  
Cohort Study ◽  
Emerging Adults ◽  
Substance Use Disorders ◽  
Population Based

scholarly journals Maternal and child gluten intake and risk of type 1 diabetes: The Norwegian Mother and Child Cohort Study

2019 ◽  
Author(s):  
Nicolai A Lund-Blix ◽  
German Tapia ◽  
Karl Mårild ◽  
Anne Lise Brantsaeter ◽  
Pål R Njølstad ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cohort Study ◽  
Confidence Interval ◽  
Population Based ◽  
Hazard Ratio ◽  
Adjusted Hazard Ratio ◽  
Pregnancy Cohort ◽  
Increased Risk ◽  
Mother And Child

ABSTRACTOBJECTIVETo examine the association between maternal and child gluten intake and risk of type 1 diabetes in children.DESIGNPregnancy cohortSETTINGPopulation-based, nation-wide study in NorwayPARTICIPANTS86,306 children in The Norwegian Mother and Child Cohort Study born from 1999 through 2009, followed to April 15, 2018.MAIN OUTCOME MEASURESClinical type 1 diabetes, ascertained in a nation-wide childhood diabetes registry. Hazard ratios were estimated using Cox regression for the exposures maternal gluten intake up to week 22 of pregnancy and child’s gluten intake when the child was 18 months old.RESULTSDuring a mean follow-up of 12.3 years (range 0.7-16.0), 346 children (0.4%) developed type 1 diabetes (incidence rate 32.6 per 100,000 person-years). The average gluten intake was 13.6 grams/day for mothers during pregnancy, and 8.8 grams/day for the child at 18 months of age. Maternal gluten intake in mid-pregnancy was not associated with the development of type 1 diabetes in the child (adjusted hazard ratio 1.02 (95% confidence interval 0.73 to 1.43) per 10 grams/day increase in gluten intake). However, the child’s gluten intake at 18 months of age was associated with an increased risk of later developing type 1 diabetes (adjusted hazard ratio 1.46 (95% confidence interval 1.06 to 2.01) per 10 grams/day increase in gluten intake).CONCLUSIONSThis study suggests that the child’s gluten intake at 18 months of age, and not the maternal intake during pregnancy, could increase the risk of type 1 diabetes in the child.WHAT IS ALREADY KNOWN ON THIS TOPICA national prospective cohort study from Denmark found that a high maternal gluten intake during pregnancy could increase the risk of type 1 diabetes in the offspring (adjusted hazard ratio 1.31 (95% confidence interval 1.001 to 1.72) per 10 grams/day increase in gluten intake). No studies have investigated the relation between the amount of gluten intake by both the mother during pregnancy and the child in early life and risk of developing type 1 diabetes in childhood.WHAT THIS STUDY ADDSIn this prospective population-based pregnancy cohort with 86,306 children of whom 346 developed type 1 diabetes we found that the child’s gluten intake at 18 months of age was associated with the risk of type 1 diabetes (adjusted hazard ratio 1.46 (95% confidence interval 1.06 to 2.01) per 10 grams/day increase in gluten intake). This study suggests that the child’s gluten intake at 18 months of age, and not the maternal intake during pregnancy, could increase the child’s risk of type 1 diabetes.

scholarly journals Incidence and risk of celiac disease after type 1 diabetes: A population‐based cohort study using the health improvement network database

2018 ◽  
Vol 19 (8) ◽  
pp. 1422-1428 ◽  
Author(s):  
Mary Ellen Vajravelu ◽  
Ron Keren ◽  
David R. Weber ◽  
Ritu Verma ◽  
Diva D. De León ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cohort Study ◽  
Celiac Disease ◽  
Population Based ◽  
Health Improvement ◽  
Network Database ◽  
The Health Improvement Network
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