Glucose tolerance and beta-cell function in islet autoantibody-positive children recruited to a secondary prevention study

2013 ◽  
Vol 14 (5) ◽  
pp. 341-349 ◽  
Author(s):  
Cecilia Andersson ◽  
Annelie Carlsson ◽  
Corrado Cilio ◽  
Elisabeth Cedervall ◽  
Sten-Anders Ivarsson ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Secondary Prevention ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Islet Autoantibody ◽  
Prevention Study ◽  
Secondary Prevention Study

Four-Year Follow-Up of Glucose Tolerance and Beta-Cell Function in Nondiabetic Cystic Fibrosis Patients

1995 ◽  
Vol 44 (2) ◽  
pp. 45-50 ◽  
Author(s):  
F. De Luca ◽  
T. Arrigo ◽  
A. Di Benedetto ◽  
A. Tedeschi ◽  
C. Sferlazzas ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Glucose Tolerance ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function

scholarly journals Investigation of the progress in the women with gestational diabetes mellitus postpartum

2021 ◽  
pp. 45-51
Author(s):  
Thi To Nhu Phan ◽  
Trung Vinh Hoang
Keyword(s):  
Diabetes Mellitus ◽  
Logistic Regression ◽  
Glucose Tolerance ◽  
Beta Cell ◽  
Glucose Intolerance ◽  
Beta Cell Function ◽  
Cell Function ◽  
Postpartum Women ◽  
Matsuda Index ◽  
History Of

Aims: Our aim was to evaluate the uptake of postpartum screening, the prevalence and the risk factors for glucose intolerance in women with a recent history of gestational diabetes mellitus (GDM). Methods: All women with a history of GDM are advised to undergo a 75g oral glucose tolerance test (OGTT) around 6 - 12 weeks postpartum. Indices of insulin sensitivity (the Matsuda index and the reciprocal of the homeostasis model assessment of insulin resistance, HOMA-IR) and an index of beta-cell function, the Insulin Secretion-Sensitivity Index-2 (ISSI-2) were calculated based on the OGTT postpartum. Multivariable logistic regression was used to some factors. Results: Of all women (135) who received an OGTT postpartum, 42.2% (57) had glucose intolerance (11.8% impaired fasting glucose, 24.4% impaired glucose tolerance and 6.0% both impaired fasting and impaired glucose tolerance) and 1.5% (2) had overt diabetes. Compared to women with a normal OGTT postpartum, women with glucose intolerance and diabetes were older (32.5 ± 4.3 vs. 30.8 ± 4.8 years, p = 0.049), were more often obese (34.5% vs. 17.3%, p = 0.023). In the multivariable logistic regression, an EM background [OR = 2.76 (1.15 - 6.62), p = 0.023] and the HbA1c level at the time of the OGTT in pregnancy [OR = 4.78 (1.19 - 19.20), p = 0.028] remained significant predictors for glucose intolerance postpartum. Women with glucose intolerance and diabetes postpartum had a similar insulin sensitivity [Matsuda index 0.656 (0.386 - 1.224) vs. 0.778 (0.532 - 1.067), p = 0.709; HOMA-IR 0.004 (0.002 - 0.009) vs. 0.064 (0.003 - 0.007), p = 0.384] but a lower beta-cell function compared to women with a normal OGTT postpartum, remaining significant after adjustment for confounders [ISSI-2 1.6 (1.2 - 2.1) vs. 1.9 (1.7 - 2.4), p = 0.002]. Conclusions: Glucose intolerance is very frequent in early postpartum in women with GDM these women have an impaired beta-cell function. Nearly one third of women did not attend the scheduled OGTT postpartum and these women have an adverse risk profile. More efforts are needed to engage and stimulate women with GDM to attend the postpartum OGTT.

scholarly journals A Systematic Review of Beta Cell Function in Adults of Black African Ethnicity

2019 ◽  
Vol 2019 ◽  
pp. 1-17 ◽  
Author(s):  
M. Ladwa ◽  
O. Hakim ◽  
S. A. Amiel ◽  
L. M. Goff
Keyword(s):  
Insulin Secretion ◽  
Glucose Tolerance ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Normal Glucose Tolerance ◽  
Qualitative Synthesis ◽  
Intravenous Glucose ◽  
Black African

Background. Understanding ethnic differences in beta cell function has important implications for preventative and therapeutic strategies in populations at high risk of type 2 diabetes (T2D). The existing literature, largely drawn from work in children and adolescents, suggests that beta cell function in black African (BA) populations is upregulated when compared to white Europeans (WE). Methods. A systematic literature search was undertaken in June 2018 to identify comparative studies of beta cell function between adults (>age 18 years) of indigenous/diasporic BA and WE ethnicity. All categories of glucose tolerance and all methodologies of assessing beta cell function in vivo were included. Results. 41 studies were identified for inclusion into a qualitative synthesis. The majority were studies in African American populations (n=30) with normal glucose tolerance (NGT)/nondiabetes (n=25), using intravenous glucose stimulation techniques (n=27). There were fewer studies in populations defined as only impaired fasting glucose/impaired glucose tolerance (IFG/IGT) (n=3) or only T2D (n=3). Although BA broadly exhibited greater peripheral insulin responses than WE, the relatively small number of studies which measured C-peptide to differentiate between beta cell insulin secretion and hepatic insulin extraction (n=14) had highly variable findings. In exclusively IGT or T2D cohorts, beta cell insulin secretion was found to be lower in BA compared to WE. Conclusions. There is inconsistent evidence for upregulated beta cell function in BA adults, and they may in fact exhibit greater deficits in insulin secretory function as glucose intolerance develops.

Hyperglycaemic Progression in Subjects with Impaired Glucose Tolerance: Association with Decline in Beta Cell Function

1993 ◽  
Vol 10 (4) ◽  
pp. 321-326 ◽  
Author(s):  
J.T.E. Cook ◽  
R.C.L. Page ◽  
J.C. Levy ◽  
M.S. Hammersley ◽  
E.K.N. Walravens ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Beta Cell ◽  
Impaired Glucose Tolerance ◽  
Beta Cell Function ◽  
Cell Function

Relationship between proinsulin and beta cell function in different states of glucose tolerance

2012 ◽  
Vol 32 (4) ◽  
pp. 219-223
Author(s):  
Ping Yu ◽  
Qiang Li ◽  
Fengchen Liu ◽  
Yuqian Sun ◽  
Jinchao Zhang
Keyword(s):  
Glucose Tolerance ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function

scholarly journals Improvement in glucose tolerance and beta-cell function in a patient with vitamin D deficiency during treatment with vitamin D.

1994 ◽  
Vol 70 (824) ◽  
pp. 440-443 ◽  
Author(s):  
S. Kumar ◽  
M. Davies ◽  
Y. Zakaria ◽  
E. B. Mawer ◽  
C. Gordon ◽  
...  
Keyword(s):  
Vitamin D ◽  
Glucose Tolerance ◽  
Beta Cell ◽  
Vitamin D Deficiency ◽  
Beta Cell Function ◽  
Cell Function
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